ijms-logo

Journal Browser

Journal Browser

Advances in Classic and Psychedelic Pharma for Psychiatric Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 4021

Special Issue Editor


E-Mail Website
Guest Editor
1. Neuropharmacology Laboratory, The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel
2. The Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan 5290002, Israel
Interests: neuropsychopharmacology; personalised medicine; epigenetics; microbiome

Special Issue Information

Dear Colleagues,

Psychiatric disorders, including post-traumatic stress disorder (PTSD) and depression, are a major public health burden with limited reliable treatments. Current behavioral and pharmacological treatments have limited efficacy; therefore, researchers are looking for novel therapeutic approaches. Interest in psychedelic-assisted treatment in psychotherapy and group treatment vs. individual treatment is growing. This news is especially intriguing since we are shifting from dealing with mood fluctuations to conciseness. As a result, we experience diverse responses to such substances. Findings allude to the molecular mechanisms underlying the idiosyncratic phenomena of psychedelic substances, triggering parallel research of other scientists to create ‘non-psychedelic’ compounds with the same anti-psychiatric effects but without the possible hallucinogenic-like side effects. This Special Issue aims to collect, compare, and discuss these converged findings promptly to reflect the molecular mechanism.

Prof. Dr. Gal Yadid
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-psychiatric drug/treatment
  • psychedelic
  • molecular mechanism
  • neurotransmission
  • plasticity
  • neurogenesis
  • response variability
 

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 10728 KiB  
Article
Cocaine-Induced Microglial Impairment and Its Rehabilitation by PLX-PAD Cell Therapy
by Hilla Pe’er-Nissan, Pnina Shirel Itzhak, Iris Gispan, Racheli Ofir and Gal Yadid
Int. J. Mol. Sci. 2025, 26(1), 234; https://doi.org/10.3390/ijms26010234 - 30 Dec 2024
Viewed by 3658
Abstract
Chronic cocaine use triggers inflammatory and oxidative processes in the central nervous system, resulting in impaired microglia. Mesenchymal stem cells, known for their immunomodulatory properties, have shown promise in reducing inflammation and enhancing neuronal survival. The study employed the cocaine self-administration model, focusing [...] Read more.
Chronic cocaine use triggers inflammatory and oxidative processes in the central nervous system, resulting in impaired microglia. Mesenchymal stem cells, known for their immunomodulatory properties, have shown promise in reducing inflammation and enhancing neuronal survival. The study employed the cocaine self-administration model, focusing on ionized calcium-binding adaptor protein 1 (Iba-1) and cell morphology as markers for microglial impairment and PLX-PAD cells as a treatment for attenuating cocaine craving. The results revealed an addiction-stage and region-specific impairment in microglia following chronic cocaine exposure, with deficits observed in the Nucleus Accumbens (NAc) during the maintenance stage and in both the NAc and Dentate Gyrus (DG) during the extinction and reinstatement stages. Furthermore, PLX-PAD cell therapy demonstrated a significant reduction in cocaine craving and seeking behavior, interestingly accompanied by the prevention of Iba-1 level decrease and restoration of microglial activity in the NAc and DG. These findings highlight the unique role of microglia in modulating cocaine addiction behaviors through their influence on synaptic plasticity and neuronal remodeling associated with memory formation. They also suggest that PLX-PAD therapy may mitigate the detrimental effects of chronic cocaine exposure on microglia, underscoring the importance of incorporating microglia in comprehensive addiction rehabilitation strategies. Full article
(This article belongs to the Special Issue Advances in Classic and Psychedelic Pharma for Psychiatric Diseases)
Show Figures

Figure 1

Back to TopTop