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Molecular Insights into Omics Sciences, Food, and Obesity: Omics Profiles of Food and Their Relationships with Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 1087

Special Issue Editor


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Guest Editor
1. CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, 28029 Madrid, Spain
2. Unitat de Nutrició Humana, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, 43201 Reus, Spain
3. Institut d’Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari San Joan de Reus, 43204 Reus, Spain
Interests: nutrition; diet; Mediterranean diet; public health; lifestyle; epidemiology; obesity; diabetes; cardiovascular diseases; cognition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Until now, epidemiology has managed to relate diet to chronic pathologies such as obesity without delving into the biological mechanisms involved in these relationships. The emergence of omic sciences such as proteomics and metabolomics allows the study of diseases, the discovery of new biomarkers, and the exploration of biochemical interactions in different biological processes. Although hundreds of epidemiological studies have analyzed the effect of diet on health, the truth is that it is unknown what molecular mechanisms are altered by food and how these alterations affect the onset and development of obesity.

This special issue aims to present current advances in omics profiles (metabolomics, metagenomics, proteomics, transcriptomics...) of food consumption, food groups, or dietary patterns and their association with the development of obesity.

Dr. Jesús Francisco García-Gavilán
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • metabolomics
  • metagenomics
  • nutrigenomics
  • dietary patterns
  • food groups
  • obesity

Published Papers (1 paper)

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Research

15 pages, 2427 KiB  
Article
Dietary Sources, Sex, and rs5888 (SCARB1) as Modulators of Vitamin A’s Effect on Cardiometabolic Health
by Sebastià Galmés, Andreu Palou and Francisca Serra
Int. J. Mol. Sci. 2023, 24(18), 14152; https://doi.org/10.3390/ijms241814152 - 15 Sep 2023
Viewed by 885
Abstract
Although preclinical studies have attributed vitamin A (VA) cardiometabolic benefits, these effects are still controversial and not always supported in large human studies. Here, the outcomes associated with VA and its relationship with habitual dietary sources, sex, and genetic background have been studied. [...] Read more.
Although preclinical studies have attributed vitamin A (VA) cardiometabolic benefits, these effects are still controversial and not always supported in large human studies. Here, the outcomes associated with VA and its relationship with habitual dietary sources, sex, and genetic background have been studied. To do so, the data from an observational study (n = 455) (64% females, mean age of 36 years) showing that suboptimal VA intake (mainly from retinol rather than carotene) is associated with cardiometabolic risk (CMR) were considered. A higher odds ratio (OR) of suffering ≥ 2 simultaneous CMR factors was observed in men in the low consumption tercile of retinol (OR = 2.04; p = 0.019). In women, however, this relationship was not evident. Then, incubation of peripheral blood mononuclear cells (PBMCs) with VA-related compounds (ex vivo functional assay from 81 men and women) induced specific changes in the activity of genes involved in lipid homeostasis and inflammatory status, which were dependent on the type of compound tested and the sex of the person. In addition, the presence of the genetic variant rs5888 in SCARB1 was identified as having a high influence on VA-related metabolic response. The new evidence derived from this study could be relevant for personalized nutritional advice concerning VA and CMR. Full article
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