Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
New Advances in Peripheral Artery Disease
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

New Advances in Peripheral Artery Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 3835

Special Issue Editor

Dr. Ayotunde O. Dokun

E-Mail Website
Guest Editor
Division of Endocrinology and Metabolism, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1182, USA
Interests: peripheral artery disease; angiogenesis; ischemia; ischemic limb; diabetes and microRNAs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Peripheral artery disease (PAD) refers to atherosclerosis causing impaired blood flow in vessels outside the heart, most commonly affecting arteries of the lower extremities. PAD affects millions of people around the world. There are two classic clinical presentations of PAD: intermittent claudication and critical limb ischemia. Individuals with intermittent claudication typically present with pain with ambulation that is relieved by rest, while those with critical limb ischemia (CLI) present with pain at rest and often have associated ulceration or gangrene. This form of PAD is associated with a high risk of limb amputation and death. The prevalence of PAD is now estimated to be higher than that of ischemic heart disease and cerebrovascular disease combined. Unlike ischemic heart disease and cerebrovascular disease, less is known about the molecular mechanisms driving the development of PAD. Moreover, diabetes, smoking and aging are critical drivers of PAD but how these factors contribute to PAD development and poorer outcomes in PAD is not well known. Currently, there are no effective medical treatments addressing the key issues in PAD, which are impaired blood flow and limb ischemic injury.

This Special Issue of the International Journal of Molecular Sciences aims to bring together the state-of-the-art views and original research on molecular mechanisms in diabetes, smoking or aging contributing to the development of PAD and PAD severity. Intervention to improve blood flow and or limb ischemic injury will also be explored.

Dr. Ayotunde O. Dokun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • peripheral artery disease
  • PAD
  • ischemic injury
  • impaired blood flow
  • atherosclerosis
 

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

11 pages, 283 KiB  
Article
Clonal Hematopoiesis Mutations Are Present in Atherosclerotic Lesions in Peripheral Artery Disease
by Petra Büttner, Julia Böttner, Knut Krohn, Ronny Baber, Uwe Platzbecker, Michael Cross, Steffen Desch, Holger Thiele, Sabine Steiner, Dierk Scheinert, Klaus H. Metzeler and Daniela Branzan
Int. J. Mol. Sci. 2023, 24(4), 3962; https://doi.org/10.3390/ijms24043962 - 16 Feb 2023
Cited by 2 | Viewed by 1441
Abstract
Clonal hematopoiesis (CH)-associated mutations increase the risk of atherosclerotic cardiovascular diseases. However, it is unclear whether the mutations detected in circulating blood cells can also be detected in tissues associated with atherosclerosis, where they could affect physiology locally. To address this, the presence [...] Read more.
Clonal hematopoiesis (CH)-associated mutations increase the risk of atherosclerotic cardiovascular diseases. However, it is unclear whether the mutations detected in circulating blood cells can also be detected in tissues associated with atherosclerosis, where they could affect physiology locally. To address this, the presence of CH mutations in peripheral blood, atherosclerotic lesions and associated tissues was assessed in a pilot study of 31 consecutive patients with peripheral vascular disease (PAD) who underwent open surgical procedures. Next-generation sequencing was used to screen the most commonly mutated loci (DNMT3A, TET2, ASXL1 and JAK2). Twenty CH mutations were detected in peripheral blood of 14 (45%) patients, 5 of whom had more than one mutation. TET2 (11 mutations, 55%) and DNMT3A (8 mutations, 40%) were the most frequently affected genes. Altogether, 88% of the mutations detectable in peripheral blood were also present in the atherosclerotic lesions. Twelve patients also had mutations in perivascular fat or subcutaneous tissue. The presence of CH mutations in PAD-associated tissues as well as in blood suggests that CH mutations may make a previously unknown contribution to PAD disease biology. Full article
(This article belongs to the Special Issue New Advances in Peripheral Artery Disease)
16 pages, 2651 KiB  
Article
BAG3 Attenuates Ischemia-Induced Skeletal Muscle Necroptosis in Diabetic Experimental Peripheral Artery Disease
by Arul M. Mani, Karthik Dhanabalan, Victor Lamin, Thomas Wong, Madhu V. Singh and Ayotunde O. Dokun
Int. J. Mol. Sci. 2022, 23(18), 10715; https://doi.org/10.3390/ijms231810715 - 14 Sep 2022
Cited by 3 | Viewed by 1966
Abstract
Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, resulting in ischemic limb injuries. Individuals with diabetes and PAD typically have more severe ischemic limb injuries and limb amputations, but the mechanisms involved are poorly understood. Previously, we [...] Read more.
Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, resulting in ischemic limb injuries. Individuals with diabetes and PAD typically have more severe ischemic limb injuries and limb amputations, but the mechanisms involved are poorly understood. Previously, we identified BAG3 as a gene within a mouse genetic locus termed limb salvage QTL1 on mouse chromosome 7 that determined the extent of limb necrosis following ischemic injury in C57Bl/6 mice. Whether BAG3 deficiency plays a role in the severe ischemic injury observed in diabetic PAD is not known. In vitro, we found simulated ischemia enhanced BAG3 expression in primary human skeletal muscle cells, whereas BAG3 knockdown increased necroptosis markers and decreased cell viability. In vivo, ischemic skeletal muscles from hind limbs of high-fat diet (HFD)-fed mice showed poor BAG3 expression compared to normal chow diet (NCD)-fed mice, and this was associated with increased limb amputations. BAG3 overexpression in ischemic skeletal muscles from hind limbs of HFD mice rescued limb amputation and improved autophagy, necroptosis, skeletal muscle function and regeneration. Therefore, BAG3 deficiency in ischemic skeletal muscles contributes to the severity of ischemic limb injury in diabetic PAD, likely through autophagy and necroptosis pathways. Full article
(This article belongs to the Special Issue New Advances in Peripheral Artery Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop