Drug Transporter in Pathological Conditions

Dear  Colleagues,

Transporters such as P-glycoprotein and organic-anion-transporting polypeptide govern the organ disposition of various drugs. The plasma membrane localization and transport activity of transporters are regulated by transporter-associated proteins. Transporter activity varies depending on factors such as age, gender, concomitant drugs, and pathological conditions. In particular, pathological conditions cause complicated effects on transporter regulation. However, the effects of pathological conditions on the expression and activity of transporters are undetermined, although those under normal conditions have been well understood. Therefore, it is important to summarize the recent findings on transporter regulation in pathological conditions.

This Special Issue attempts to explore the recent advances in transporter regulation in pathological conditions. We welcome original research or review papers demonstrating the mechanisms of transporter regulation in pathological conditions, and the changes in expression and activity in pathological conditions using in vivo or in vitro models of animals as well as clinical settings.

Dr. Atsushi Kawase
Guest Editor

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