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Nanoparticles for Cancer Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 993

Special Issue Editor


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Guest Editor
Department of Pharmaceutical Sciences, University of Milan, Via Venezian, 21, 20133 Milan, Italy
Interests: nanomaterials; organic chemistry; bioorthogonal chemistry; nanomedicine; biocompatible polymers

Special Issue Information

Dear Colleagues,

Intense research on polymers and nanomaterials for cancer therapies has resulted in the approval of various nanomedicine-based treatments in the last decade, with the protocols including metallic and polymer‑based nanoparticles for chemo, thermal, and radiotherapy. These advancements demonstrate the potentiality of nanomedicine in providing substantial contributions toward the clinical translation of advanced anticancer strategies. The high interdisciplinarity of nanomaterial-based anticancer treatments draws on and adds to knowledge from multiple areas, including polymers, inorganic, and organic chemistry. Scaffold design methods integrate the expertise and techniques of polymer science and nanomaterial chemistry. The ultimate application of these systems in cells and in vivo offers new tools for chemical biology and nanomedicine.

This Special Issue of IJMS focuses on nanomedicine strategies featuring polymeric, organic, and inorganic-based scaffolds for the production of tools and techniques required to overcome current challenges in the translation of nanomaterials for cancer therapies. Examples of contributions include research based on localized drug generation, nanotherapeutics, bioorthogonal approaches, tumor-targeted treatments, biocompatible polymers, and bioresorbable materials. Interdisciplinary research works are very welcome, and submissions can be original research reports, reviews, perspectives/opinions, and methodology articles.

Dr. Stefano Fedeli
Guest Editor

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Keywords

  • cancer treatments
  • nanomedicine
  • biocompatible polymers
  • drug-delivery
  • nanoparticles
  • bio-orthogonal chemistry
  • nanomaterials
  • gold nanoparticles
  • biodegradable polymers
  • tumor

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Published Papers (1 paper)

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Review

25 pages, 1539 KiB  
Review
Functionalized Nanomaterials in Cancer Treatment: A Review
by Oscar Gutiérrez Coronado, Cuauhtémoc Sandoval Salazar, José Luis Muñoz Carrillo, Oscar Alexander Gutiérrez Villalobos, María de la Luz Miranda Beltrán, Alejandro David Soriano Hernández, Vicente Beltrán Campos and Paola Trinidad Villalobos Gutiérrez
Int. J. Mol. Sci. 2025, 26(6), 2633; https://doi.org/10.3390/ijms26062633 - 14 Mar 2025
Viewed by 643
Abstract
Cancer is one of the main causes of death worldwide. Chemotherapy, radiotherapy and surgery are currently the treatments of choice for cancer. However, conventional therapies have their limitations, such as non-specificity, tumor recurrence and toxicity to the target cells. Recently, nanomaterials have been [...] Read more.
Cancer is one of the main causes of death worldwide. Chemotherapy, radiotherapy and surgery are currently the treatments of choice for cancer. However, conventional therapies have their limitations, such as non-specificity, tumor recurrence and toxicity to the target cells. Recently, nanomaterials have been considered as therapeutic agents against cancer. This is mainly due to their unique optical properties, biocompatibility, large surface area and nanoscale size. These properties are crucial as they can affect biocompatibility and uptake by the cell, reducing efficacy. However, because nanoparticles can be functionalized with biomolecules, they become more biocompatible, which improves uptake, and they can be specifically targeted against cancer cells, which improves their anticancer activity. In this review, we summarize some of the recent studies in which nanomaterials have been functionalized with the aim of increasing therapeutic efficacy in cancer treatment. Full article
(This article belongs to the Special Issue Nanoparticles for Cancer Treatment)
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