Genetic and Epigenetic Control of Disease Occurrence

Dear Colleagues,

The genetic background is an important contributor to susceptibility to human disease. Deciphering the genetic and molecular basis of human traits and disease is a primary problem in biology and personalized medicine. However, an increasing subclass of disease-causing mutations includes changes in the epigenome or in the amount and activity of proteins that can regulate the chromatin structure. Without changing the genomic sequence, epigenetic modifications, in response to a specific environment, could cause genomic susceptibilities, impacting the later development of human diseases.  This Special Issue on “Genetic and Epigenetic Control of Disease Occurrence” aims to highlight recent advances in the field of genomics and transcriptomics towards the translation of genotype to phenotype and the development of analytical methods to understand how the environment and genetics interact to impact health through epigenetics mechanisms. I would like to invite authors to contribute to the collection of manuscripts and review articles on recent advances regarding the molecular basis of human disease. Reports pertaining to potentially damaging isolated variants without strong arguments implicating them as causal defects will be given low priority.

Dr. Valentina Gatta
Guest Editor

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