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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Insights into Diseases Related to Mitochondrial Dysfunction: From Diagnosis to Treatment

edited by Luigi Citrigno and Annamaria Cerantonio

submission deadline 16 Feb 2026 | Viewed by 247 | Submission Open

Keywords: mitochondrial dysfunction; mtDNA mutations; genetic diagnosis; next-generation sequencing; neurodegeneration; metabolic disorders; mitochondrial therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Pediatric Rare Diseases: Genetics and Diagnosis

edited by Antonio F. Martínez‐Monseny

submission deadline 20 Feb 2026 | 2 articles | Viewed by 6298 | Submission Open

Keywords: rare diseases; genetics; pediatrics; dysmorphology; molecular diagnosis; genetic syndromes; genome; precision medicine; phenotype

(This special issue belongs to the Section Molecular Genetics and Genomics)

Computational Genomics and Bioinformatics of Cancer

edited by

Ilya Ioshikhes

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5570 | Submission Open

Keywords: cancer; data analysis; bioinformatics; complex diseases; dimensionality reduction; genetics; epigenetics; gene regulation; molecular mechanism; environmental factors

(This special issue belongs to the Section Bioinformatics)

Roles of RNAs in Biology

edited by

Zihua Hu

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2234 | Submission Open

Keywords: regulatory RNAs; non-coding RNAs; RNA in disease and therapy; RNA modifications including editing; RNA-RNA interaction including microRNAs; RNA in transcriptional and post-transcriptional regulation; non-coding RNA in epigenetic regulation

(This special issue belongs to the Section RNA)

Genetic and Molecular Mechanisms of Crop Resistance

edited by

Quanle Xu

submission deadline 20 Feb 2026 | Viewed by 306 | Submission Open

Keywords: abiotic and biotic stress; crop resilience; molecular mechanism; molecular breeding; resilient crops

(This special issue belongs to the Section Plant Genetics and Genomics)

Extracellular Vesicles in Genetic Diseases: Emerging Biomarkers and Clinical Applications

edited by Benedetta Niccolini and

Elisabetta Tabolacci

submission deadline 20 Feb 2026 | Viewed by 98 | Submission Open

Keywords: extracellular vesicles; inherited diseases; EV-derived microRNAs; biomarkers; genetic disorders; patient stratification; therapeutic monitoring; disease progression; intercellular communication; molecular diagnostics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advanced Research in Forensic Genetics

edited by

Mauro Pesaresi

submission deadline 25 Feb 2026 | 5 articles | Viewed by 5996 | Submission Open

Keywords: forensic genetics; massive parallel sequencing (MPS); DNA quantification methods; DNA extraction methods; sudden cardiac death; post-mortem interval; microRNA; DNA phenotyping; individual identification; genetic markers; short tandem repeats (STRs); single-nucleotide polymorphism (SNP); mitochondrial DNA (mtDNA); microhaplotype; forensic statistics; artificial intelligence; activity level in forensics

(This special issue belongs to the Section Molecular Genetics and Genomics)

DNA Repair, Genomic Instability and Cancer

edited by

Karen M. Vasquez

submission deadline 25 Feb 2026 | 2 articles | Viewed by 1923 | Submission Open

Keywords: DNA structure; DNA damage; DNA repair; genomic instability; mutagenesis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Genomic Mechanisms of Heat Stress in Disease Modulation: From Molecular Pathways to Clinical Manifestations

edited by

Hisahide Nishio

and

Hiroyuki Awano

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1343 | Submission Open

Keywords: heatstroke; global warming; heat stress; neurodegenerative diseases; molecular pathogenesis; gene– environment interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advancing Nephrogenetics: Diagnosis, Genetic Testing, and Treatment Innovations

edited by

Katarina Vukojević

, Anita Racetin and

Nela Kelam

submission deadline 25 Feb 2026 | Viewed by 391 | Submission Open

Keywords: nephrogenetics; hereditary kidney disease; genetic testing; next-generation sequencing; renal genomics; precision nephrology; gene therapy; targeted treatment; personalized medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Host Genetics Shapes the Gut Microbiome: From Genes to Microbiota

edited by

Shaoqiu Chen

submission deadline 25 Feb 2026 | Viewed by 314 | Submission Open

Keywords: gut microbiome; host genetics; microbiota; multi-omics; host– microbe interaction; genetic variation; 16S rRNA sequencing; bioinformatics; personalized medicine

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetics of Ehlers–Danlos Syndrome and Related Connective Tissue Disorders

edited by Irman Forghani

submission deadline 25 Feb 2026 | Viewed by 246 | Submission Open

Keywords: Ehlers– Danlos syndrome; Marfan syndrome; connective tissue disorders; extracellular matrix; Loeys– Dietz syndrome; genotype– phenotype correlation; aortopathies; hypermobility syndromes

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics in Headache and Neurogenic Pain

edited by Yohannes W. Woldeamanuel and Xianghong Arakaki

submission deadline 25 Feb 2026 | Viewed by 230 | Submission Open

Keywords: genetics; headache; neurogenic pain; migraine; genomics; epigenetics; polygenic risk; biomarkers; precision medicine; CRISPR; neuropathic pain; gene– environment interactions; translational research; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Neurogenomics)

Unraveling the Genetic Tapestry of Human Populations: New Insights from Population Genetics and Identification in Anthropology

edited by

Lovorka Barać Lauc

submission deadline 25 Feb 2026 | Viewed by 217 | Submission Open

Keywords: human genetic diversity; population genetics; migration patterns; admixture; isolated populations; ancestry reconstruction; anthropological genomics; biomedical relevance; forensic identification

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genomics and Gene Expression of the Oral Microbiome

edited by

Johan Samot

and

Mahmoud Rouabhia

submission deadline 25 Feb 2026 | Viewed by 171 | Submission Open

Keywords: oral microbiome; gene expression regulation; metagenomics; transcriptome; horizontal gene transfer; antimicrobial resistance; biofilms; bacteriophages; virulence factors

(This special issue belongs to the Section Microbial Genetics and Genomics)

Driver Genes in Prostate Carcinogenesis and Resistance to Treatment

edited by

Daotai Nie

submission deadline 25 Feb 2026 | Viewed by 123 | Submission Open

Keywords: genomic instability; driver genes; prostate cancer prevention; castration therapy; drug resistance

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Breeding of Tea Tree and Tea Plant

edited by Lianyu Yuan

submission deadline 25 Feb 2026 | Viewed by 110 | Submission Open

Keywords: gene function analysis; genome analysis; biotechnological breeding; genetic diversity; breeding technology; multi-omics analysis; tea plant

(This special issue belongs to the Section Plant Genetics and Genomics)

Research on Genetics and Breeding of Cattle

edited by

Borhan Shokrollahi

submission deadline 5 Mar 2026 | 3 articles | Viewed by 3501 | Submission Open

Keywords: reproductive genetics and biotechnology; biotechnology in cattle; genomic selection; marker-assisted breeding; genetic diversity; assisted reproductive technologies; molecular genetics; fertility and reproduction; cattle breeding strategies; epigenetics

(This special issue belongs to the Section Animal Genetics and Genomics)

AI and Neurogenomics: Innovations in Precision Medicine for Brain Disorders

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 5 Mar 2026 | 2 articles | Viewed by 2985 | Submission Open

Keywords: neurogenetics; genomics; artificial intelligence; brain disorders; neurodegenerative disease

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Profiling and Molecular Analysis in Autism Spectrum Disorders

edited by John Jay Gargus

submission deadline 5 Mar 2026 | Viewed by 208 | Submission Open

Keywords: whole-exome and genome sequencing in ASD; functional genomics of high-confidence ASD risk genes; transcriptomics and splicing variants in the autistic brain; calcium signaling and ion channelopathies; chromatin and epigenetic dysregulation in ASD; mitochondrial dysfunction and oxidative stress; immune– neural signaling cross-talk; systemic extracerebral traits associated with ASD; stratification of ASD subtypes; sex-biased molecular mechanisms in ASD; integrative omics for therapeutic target discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics of Endocrine Diseases in Children and Adolescents

edited by

Malgorzata Wasniewska

submission deadline 10 Mar 2026 | 2 articles | Viewed by 4263 | Submission Open

Keywords: endocrine disease; endocrine gland; genetic syndrome; genetic polymorphism; genetic pathomechanism

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Basis in Rare Genetic Disorders

edited by

Miao Sun

submission deadline 10 Mar 2026 | 1 articles | Viewed by 759 | Submission Open

Keywords: nucleotide and mitochondrial DNA; RNA modification; epigenetics; gene expression; rare disease and inheritance; clinical pathology; disease mechanism; bioinformatics and tools; functional studies; treatment and therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Prenatal and Postnatal Genetic Testing: Precision Diagnosis for Genetic Disorders

edited by

Spiros Vittas

and Eirini Louizou

submission deadline 10 Mar 2026 | Viewed by 466 | Submission Open

Keywords: genetic testing; prenatal diagnosis; postnatal diagnosis; precision medicine

(This special issue belongs to the Section Genetic Diagnosis)

Reviews in RNA: Mechanisms and Roles

edited by

Laurent Metzinger

and

Valérie Metzinger-Le Meuth

submission deadline 10 Mar 2026 | Viewed by 331 | Submission Open

Keywords: gene regulation; non-coding RNA; RNA world; RNA-related metabolism

(This special issue belongs to the Section RNA)

Genetic Insights into Immunity and Pathogen Resistance

edited by

Fabiana Neves

and Tereza Almeida

submission deadline 10 Mar 2026 | Viewed by 222 | Submission Open

Keywords: immunogenetics; host– pathogen coevolution; genetic variation; functional genomics; comparative immunology; CRISPR; pathogen resistance; evolutionary immunology; epigenetics; genome-wide association studies (GWASs)

(This special issue belongs to the Section Molecular Genetics and Genomics)

Precision Genome Engineering in Plants

edited by

Weibin Song

and Zhiyong Zhang

submission deadline 10 Mar 2026 | Viewed by 99 | Submission Open

Keywords: CRISPR-Cas9; genome editing; base editing; prime editing; crop improvement; gene targeting; synthetic biology; plant biotechnology; off-target effects; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Physiological and Molecular Mechanisms of Plant Stress Response

edited by

Yakupjan Haxim

submission deadline 15 Mar 2026 | 3 articles | Viewed by 2707 | Submission Open

Keywords: drought stress; heat stress; cold stress; salinity stress; pathogen infection; multi-omic approaches; gene expression; plant resistance

(This special issue belongs to the Section Plant Genetics and Genomics)

Epigenetic Regulation in Tumors

edited by

Anca Botezatu

submission deadline 15 Mar 2026 | Viewed by 1108 | Submission Open

Keywords: cancer epigenetics; epigenetic mechanisms; tumor microenvironment; epigenetic biomarkers; multi-omics and bioinformatics

(This special issue belongs to the Section Epigenomics)

Unveiling Human Microbiome Composition and Functions to Improve Health and Disease Research

edited by

Valeria D’Argenio

submission deadline 15 Mar 2026 | 1 articles | Viewed by 842 | Submission Open

Keywords: human microbiome; health and disease; precision medicine; host– microbe interactions; translational research; metagenomics; multi-omics approaches

(This special issue belongs to the Section Microbial Genetics and Genomics)

Harnessing Multi-Omics Approaches to Unravel Plant–Microbe Interactions in Cultivated Plants: Implications for Climate Resilience and Sustainable Agriculture

edited by Samathmika Ravi,

Maria Cristina Della Lucia

and

Piergiorgio Stevanato

submission deadline 15 Mar 2026 | Viewed by 385 | Submission Open

Keywords: multi-omics; plant– microbe interactions; climate resilience; agricultural sustainability; microbial dynamics

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics of Host–Pathogen Interactions

edited by

Transito Garcia-Garcia

and Sara Zaldívar López

submission deadline 15 Mar 2026 | 1 articles | Viewed by 367 | Submission Open

Keywords: pathogen virulence factors; infection susceptibility; immune evasion; genomics of infectious diseases; host– pathogen co-evolution; host– pathogen dynamics; microbiome– host interactions; emerging infectious diseases; crispr and gene editing in host– pathogen studies; transcriptomics and gene expression profiling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic Dynamics in Cancer and Aging

edited by

Hayan Lee

submission deadline 15 Mar 2026 | Viewed by 331 | Submission Open

Keywords: DNA methylation; histone modification; chromatin 3D modeling; non-coding RNA; long-read sequencing technology; single-cell epigenetics; cancer initiation and development; epigenetic alterations in the aging process; aging-specific epigenetic alterations; cancer-specific epigenetic alterations

(This special issue belongs to the Section Epigenomics)

Genetic Markers in Targeted Therapies: From Biomarker Discovery to Personalized Therapy

edited by

Maciej Wnuk

submission deadline 15 Mar 2026 | Viewed by 184 | Submission Open

Keywords: cancer diagnosis; molecular; cytogenetic biomarkers; genomic instability; cellular senescence; human disease; clinical applications; personalized therapy; theranostics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic Landscape of Neurodevelopmental Disorders

edited by Bimal Jana

submission deadline 15 Mar 2026 | Viewed by 106 | Submission Open

Keywords: epigenetics; neurodevelopmental disorders (NDDs); DNA methylation; 3D genome architecture; histone modifications; non-coding RNA; autism spectrum disorder (ASD); Rett syndrome; neurodevelopment; gene-environment interaction; epigenetic biomarkers; single-cell epigenomics; epigenetic therapy

(This special issue belongs to the Section Neurogenomics)

Cancer Epigenetics: From Laboratory Studies and Clinical Trials to Precision Medicine

edited by Rajendra Pangeni

submission deadline 15 Mar 2026 | Viewed by 86 | Submission Open

Keywords: cancer; epigenetics; laboratory studies; tumor biology; precision medicine; clinical trials; therapy resistance; biomarkers; personalized care; therapeutic interventions

(This special issue belongs to the Section Epigenomics)

Forensic DNA Profiling: PCR Techniques and Innovations

edited by

António Amorim

and

Laura Mendes Cainé

submission deadline 16 Mar 2026 | 1 articles | Viewed by 819 | Submission Open

Keywords: forensic DNA profiling; PCR-based forensics; DNA analysis; next-generation sequencing; short tandem repeat (STR); Y-STR; single-nucleotide polymorphisms (SNPs); Y-SNP

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

RNA Biology and Diseases

edited by Sharon Moshitch-Moshkovitz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 666 | Submission Open

Keywords: mechanisms of RNA processing; RNA modification and epitranscriptomics; regulatory RNAs; RNA-based therapy (ASOs; targeted modifications); RNA– protein interactions; non-coding RNAs and diseases; post-translational modifications in shaping the epitranscriptome; RNA structures and restructuring mechanisms

(This special issue belongs to the Section RNA)

Genetic Diagnosis and Genomics of Neurological Diseases

edited by

Avi Fellner

and Penina Ponger

submission deadline 20 Mar 2026 | Viewed by 417 | Submission Open

Keywords: neurogenetics; hereditary neurological diseases; genetic diagnosis; genotype– phenotype correlation; next-generation sequencing; precision neurology; clinical genomics; diagnostic yield; genomic technologies; data-driven approaches

(This special issue belongs to the Section Genetic Diagnosis)

The Regulation of mRNA Translation in Health and Disease

edited by Jun Ling

submission deadline 20 Mar 2026 | Viewed by 371 | Submission Open

Keywords: mRNA translation; mRNA biology; transcriptional regulation; cell signaling; cancer therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mouse Models of Human Disease

edited by Jiale Wang

submission deadline 20 Mar 2026 | Viewed by 307 | Submission Open

Keywords: mouse models; human disease; genetic disorders; genome editing; CRISPR; inflammation; cancer biology; disease mechanisms; preclinical models; translational research

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Non-Coding RNA in Cancer

edited by Amil M. Shah

submission deadline 20 Mar 2026 | Viewed by 229 | Submission Open

Keywords: non-coding RNA (ncRNA); ncRNA classification; ncRNA biogenesis; ncRNA functions; diagnostic and prognostic biomarkers; targeted therapy; nucleic acid-based therapy; cell regulatory networks; cancer attractor states; computational network models; omics technology (single-cell RNA-seq; spatial transcriptomics; and single-cell multi-omics)

(This special issue belongs to the Section RNA)

Canine Genomics and Disease Research

edited by

Jeffrey Kidd

submission deadline 20 Mar 2026 | Viewed by 203 | Submission Open

Keywords: canine genetics; trait mapping; genome structure and function; population genetics; association studies; canine evolution; canine disease

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics and Reproduction in Pigs

edited by Rui Cai

submission deadline 20 Mar 2026 | Viewed by 176 | Submission Open

Keywords: pig; spermatogenesis; semen preservation; reproductive technology; genomic selection

(This special issue belongs to the Section Animal Genetics and Genomics)

Machine Learning in Cancer and Disease Genomics

edited by

Piero Fariselli

and Giovanni Birolo

submission deadline 25 Mar 2026 | 6 articles | Viewed by 20308 | Submission Open

Keywords: machine learning; cancer genomics; disease genomics; bioinformatics; genomic data analysis; biomarker discovery; multi-omics integration; personalized medicine; computational biology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Epigenetics of Cellular Differentiation

edited by

Theodora Sideri

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1179 | Submission Open

Keywords: stem cells; differentiation; gene expression; genetics; histone modifications; DNA methylation

(This special issue belongs to the Section Epigenomics)

Genetics and Genomics of Insects

edited by Hui Ai

submission deadline 25 Mar 2026 | 2 articles | Viewed by 1172 | Submission Open

Keywords: insect molecular biology; genomics; molecular systematics; transcriptomics; genetic; genomic; pest management strategies; gene function; insect chemical ecology

(This special issue belongs to the Section Animal Genetics and Genomics)

Utilizing Multi-Omics to Investigate Neurodegenerative Disorders

edited by Muhammad Ali

submission deadline 25 Mar 2026 | Viewed by 554 | Submission Open

Keywords: neurodegeneration; central nervous system; diagnosis; prognosis; biomarkers; predictive modeling; brain; cerebrospinal fluid; plasma; multi-omics

(This special issue belongs to the Section Neurogenomics)

Genetic Aspects of Autoimmune Diseases

edited by Cheuk Wun Li

submission deadline 25 Mar 2026 | 1 articles | Viewed by 420 | Submission Open

Keywords: autoimmune diseases; genetics; genetic variants; polygenic; therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mitochondrial Genetics: Progress and Challenges

edited by

Konstantin Khrapko

submission deadline 25 Mar 2026 | Viewed by 392 | Submission Open

Keywords: Mitochondria; ; mtDNA; ; mutation; ; selection; ; germline; ; mitchondrial disease; ; inheritance; ; population; ; evolution; ; NUMT

(This special issue belongs to the Section Molecular Genetics and Genomics)

Livestock Germplasm Resources, Genetics, and Breeding

edited by

Enrico D’ Alessandro

and Marco Tolone

submission deadline 25 Mar 2026 | Viewed by 327 | Submission Open

Keywords: animal genetics; genomics; animal production; metagenomics; genome-wide association study (GWAS); product quality; fertility; health; coat color; molecular traceability; biodiversity

(This special issue belongs to the Section Animal Genetics and Genomics)

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