miRNA Regulation
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 June 2014) | Viewed by 107426
Special Issue Editor
Interests: type 1 diabetes; type 2 diabetes; PCOS; oxidative stress; miRNA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The field of microRNA biology is growing with exponential speed. Since the first microRNA was identified in 1993 by Victor Ambros and colleagues (the lin-4 heterochronic gene in C. Elegans), more than 24,000 microRNAs have now been identified. MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. However, the role of microRNA in mammalian tissue development and differentiation is still quite uncharacterized. Therefore, it is important to describe their mechanisms of actions, expression patterns and possible target genes and cellular pathways with which they interact. This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes.
Dr. Louise Dalgaard
Guest Editor
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Keywords
- microRNAs and
- developmental timing
- cellular differentiation
- regeneration
- proliferation
- target genes
- cancer, metabolism and diabetes, autoimmunity, aging
- expression patterns
- biomarker identification
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