mtDNA and Mitochondrial Stress Signaling in Cancers
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (25 October 2023) | Viewed by 2976
Special Issue Editors
Interests: cancers treatment; chemotherapy; immunotherapy; mitochondrial DNA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
To date, the role of mitochondria and changes in mitochondrial DNA in carcinogenesis are perceived as complex and not fully understood. Most of the mtDNA somatic mutations in tumors have been also reported as polymorphisms in the general population. Numerous researchers have indicated a relationship between the occurrence of polymorphisms in mtDNA and an increased risk of cancer, including breast or prostate cancer. Their position in a given mitochondrial haplogroup may not only promote the development of cancer, but also protect against its occurrence.
Clinical manifestation of changes in mtDNA may occur as a result of the coexistence and interaction of various external and internal factors. Thus, the coexistence of mitochondrial polymorphisms may contribute to cell energy disturbances and promote the formation of cancers.
The mitochondria of cancer cells have the ability to adapt to both metabolic and oxidative stress. Mitochondrial stress response mitigation via signaling pathways maintains mitochondrial integrity. Maintaining the integrity of the mitochondria in the stress response is one of the reasons for the progression and resistance of tumors to treatment. Research on mtDNA, as well as the signaling pathways that affect mitochondrial stability, may contribute to a better understanding of the carcinogenesis processes, and thus to the introduction of new anti-cancer therapies.
Potential topics include, but are not limited to, the following:
- Polymorphism and mutations of mtDNA in tumors.
- Oxydative phosphorylation in tumors.
- Signaling pathways and mitochondrias in tumors.
- Mitochondrial metabolism in tumors.
- Mitochondria and metabolic or oxydative stress.
Dr. Ludmiła Grzybowska-Szatkowska
Prof. Dr. Brygida Ślaska
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mtDNA
- signaling pathways
- oxidative stress
- mitochondria
- carcinogenesis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
