Innovative Approaches to Obtaining Functional Compounds from Agri-Food Byproducts

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 7594

Special Issue Editors


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Guest Editor
Department of Management, Sapienza University of Rome, Via del Castro Laurenziano 9, 00161 Rome, Italy
Interests: food quality and safety; functional foods; agri-food wastes; circular economy; chromatography; antioxidants
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Guest Editor
Department of Pharmacy, Health, and Nutritional Sciences, University of Calabria Via Pietro Bucci, 87036 Arcavacata di Rende, CS, Italy
Interests: synthesis of heterocyclic compounds; chemotherapeutics; antioxidants; food-derived bioactive molecules; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The agri-food industry generates huge amounts of byproducts throughout the supply chain, from harvesting to processing and consumption. In particular, agri-food wastes are not considered to be either food loss or food waste; thus, they are not covered by the European Union’s action plan related to the SDG target 12.3. The management and disposal of these matrices represent a severe environmental load, and current regulations mainly allow for them to be exploited as land fertilizers and/or heat sources. However, they contain valuable functional compounds with potential uses in further production cycles, including food and nutraceutical fields. In this sense, sustainability and circular economy principles can be supported by facing environmental challenges while creating economic opportunities.

The growing interest in functional foods highlights the need for innovative, cost-effective, and eco-friendly strategies to recover and utilize these compounds, keeping in mind legal and nutritional compliance.

In this context, this Special Issue invites contributions focusing on the following topics:

  • Innovative extraction methods recovering functional compounds from agri-food wastes;
  • Advanced characterization of agri-food wastes and related extracts;
  • Bioactivity studies for potential health benefits;
  • Innovative food formulations, including gluten-free products, using compounds from agro-industrial byproducts;
  • Integration of circular economy practices and waste management in valorizing agro-industrial byproducts;
  • Applications of functional compounds in food and nutraceuticals to enhance functionality and health benefits;
  • Regulatory and normative aspects concerning the use of functional compounds and their applications;
  • Development of innovative delivery systems to improve the stability and functionality of bioactive compounds;
  • Case studies on the economic feasibility, environmental impact, and consumer acceptance of products derived from agro-industrial byproducts.

Dr. Donatella Restuccia
Dr. Francesca Aiello
Guest Editors

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Keywords

  • agri-food wastes
  • functional compounds
  • nutraceuticals
  • innovative extractions
  • circular economy
  • waste management
  • food sustainability
  • innovative food formulations

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Published Papers (2 papers)

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Research

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18 pages, 880 KB  
Article
Upcycling Grape Pomace in a Plant-Based Yogurt Alternative: Starter Selection, Phenolic Profiling, and Antioxidant Efficacy on Human Keratinocytes
by Andrea Torreggiani, Mario Caponio, Daniela Pinto, Giorgia Mondadori, Vito Verardo, Ana María Gómez-Caravaca, Michela Verni and Carlo Giuseppe Rizzello
Foods 2025, 14(24), 4294; https://doi.org/10.3390/foods14244294 - 13 Dec 2025
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Abstract
Due to its appealing composition, grape pomace (GP), the major by-product of the wine industry, could be considered an ideal candidate for innovative functional foods development. In this study, a rice/GP-yogurt alternative, also known as gurt, fermented with selected lactic acid bacteria, was [...] Read more.
Due to its appealing composition, grape pomace (GP), the major by-product of the wine industry, could be considered an ideal candidate for innovative functional foods development. In this study, a rice/GP-yogurt alternative, also known as gurt, fermented with selected lactic acid bacteria, was designed. An extensive characterization of the gurts led to the selection of the one fermented with Lactiplantibacillus plantarum T0A10. The strains showed good pro-technological performances (fast acidification and growth up to 9 log cfu/g in the specific plant-based composite substrate), as well as the ability to increase DPPH radical scavenging activity compared to the unfermented control (57% against 40%). Then, an in-depth focus on the effect of fermentation on phenolic compounds and their related antioxidant efficacy on human keratinocytes was provided, elucidating a compound/function relationship. Fermentation significantly modified the phenolic profile of the gurt, reducing glycosylated forms of flavonols and phenolic acids and increasing the content of catechin and pyrogallol (more than 100 mg/kg combined). Such modification was responsible for significantly up-regulating (p < 0.05) the expression of the antioxidant enzyme superoxide dismutase 2, thus protecting NCTC 2544 cells against oxidative stress. Overall, these findings provide a foundation for developing value-added products from GP, supporting both circular economy initiatives and functional ingredient innovation. Full article
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Review

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29 pages, 1402 KB  
Review
The Valorization of Potato Peels as a Functional Ingredient in the Food Industry: A Comprehensive Review
by Domizia Vescovo, Cesare Manetti, Roberto Ruggieri, Umile Gianfranco Spizzirri, Francesca Aiello, Maria Martuscelli and Donatella Restuccia
Foods 2025, 14(8), 1333; https://doi.org/10.3390/foods14081333 - 12 Apr 2025
Cited by 10 | Viewed by 6961
Abstract
Potato peels (PPs) represent a significant agro-industrial by-product with notable potential for valorization due to their rich composition of bioactive compounds, including phenolics, glycoalkaloids, dietary fiber, and essential minerals. This review explores the functional applications of PPs in the food industry by examining [...] Read more.
Potato peels (PPs) represent a significant agro-industrial by-product with notable potential for valorization due to their rich composition of bioactive compounds, including phenolics, glycoalkaloids, dietary fiber, and essential minerals. This review explores the functional applications of PPs in the food industry by examining their chemical profile, extraction methods, and biological activities. Phenolic compounds, mainly chlorogenic acid and its derivatives, are the most abundant bioactives and contribute to antioxidant and anti-inflammatory properties. Glycoalkaloids, such as α-solanine and α-chaconine, exhibit antimicrobial activity but require careful monitoring due to their potential toxicity, although recent evidence suggests that controlled doses may provide health benefits. The choice of extraction technique influences the recovery of these compounds, with ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) proving to be efficient and environmentally friendly alternatives to conventional methods. The incorporation of PP-derived ingredients into food formulations, including cereal, dairy, meat, and fish products, as well as vegetable oils, has shown promising results in the improvement of nutritional quality, oxidative stability and functional properties. However, challenges remain with regard to the standardization of PP composition, bioavailability of bioactive compounds and their stability within food matrices. Advancing research on PPs will not only contribute to circular economy goals but also provide innovative solutions for the food industry, reinforcing the link between sustainability and human health. Full article
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