Scale-Up Challenges in Microbial Fermentation

Dear Colleagues,

Remarkable achievements and progress have been made in all scientific aspects of microbes, from their molecular genetics and metabolic processes to the biosynthesis of industrially important products. However, in most cases, there have been few advancements in the effective and economic translation of these scientific achievements into industrial-scale processes. There are numerous challenges in implementing laboratory experiments in the large-scale production of commercially desirable microbial products.

In this context, this Special Issue is focused on scale-up challenges in microbial fermentation. We invite original research manuscripts and in-depth review articles featuring scale-up and considering the following topics:

Batch, fed-batch, and continuous cultures;

Free- and immobilised-cell cultures;

Pure and mixed microbial cultures;

Scale-down approaches for economic scale-up;

Bioreactor designs (stirred-tank reactors, air-lift reactors, membrane reactors, membrane-linked reactors, and other designs) for successful scale-up;

Microbial fuel cells;

The morphological consideration of cultures;

Hydrodynamics of scale;

Shear stress and biofilm formation and other issues affecting scale-up.

We will consider manuscripts exploring all types of fermentation, including but not limited to those for the production of therapeutics, enzymes, food, vitamins, biofuels, biomass, and fine chemicals.

Prof. Dr. Tajalli Keshavarz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• microbes
• free-cell culture
• immobilised-cell culture
• bioreactor designs
• modes of fermentation
• scale-up
• scale-down