Yarrowia lipolytica: A Beneficial Yeast as a Biofactory for Biotechnological Applications: 2nd Edition

Dear Colleagues,

Yeasts were used for fermentation processes long before their various properties were discovered and described. Among at least 1500 recognized yeast species, in addition to the most well-known baker’s yeasts, e.g., Saccharomyces cerevisiae, other yeasts also stand out, often characterized by their unique features and capabilities.

Yarrowia lipolytica is one of the most studied “non-conventional” yeast species. The high secretory capacity and the capability of biosynthesis of many important secondary metabolites affect the growing scientific interest and biotechnological importance of this yeast. Y. lipolytica is considered to be non-pathogenic, and additionally, some commercial-scale processes with its participation have been granted GRAS (generally recognized as safe) status by the US Food and Drug Administration (FDA). The major advantages of using Y. lipolytica are its ability to grow and consume of a wide range of substrates, such as alkanes, fatty acids, fats, and oils, as well as some waste substrates, namely, crude glycerol, waste cooking oils, sewage sludge, or olive mill wastewater, with simultaneous biosynthesis of varied metabolites.

This Special Issue will compile the current state-of-the-art research on Y. lipolytica and shed light on the current research directions with the use of this yeast. Potential topics include but are not limited to the following:

- Metabolic engineering of Y. lipolytica;
- The biosynthesis of secondary metabolites, namely enzymes, e.g., lipases or proteases, as well as organic acids, sugar alcohols, flavors, and aromas;
- Whole-cell catalysis;
- Lipid biosynthesis and accumulation;
- Utilization of agri-food waste.

Dr. Bartłomiej Zieniuk
Guest Editor

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