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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Anatomy and Diagnosis in 2026

edited by Ji-Hyun Lee

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1423 | Submission Open

Keywords: clinical anatomy; radiological anatomy; applied anatomy; anatomical variations; pathoanatomy; artificial intelligence in anatomy; anatomical research innovation; anatomical education

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Medical Image Analysis and Clinical Decision Support

edited by Zahid Ullah and Tahir Mahmood

submission deadline 31 Dec 2026 | 3 articles | Viewed by 1398 | Submission Open

Keywords: medical image analysis; deep learning; vision transformers; medical image segmentation; clinical decision support; multimodal learning; explainable AI; continual learning; federated learning; healthcare AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

AI-Powered Ophthalmic Diagnostics: From Image Segmentation to Disease Classification

edited by

Yanwu Xu

Weihua Yang

and

Huihui Fang

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1387 | Submission Open

Keywords: ophthalmic artificial intelligence; medical image segmentation; disease classification; ocular imaging; deep learning and foundation models; explainable AI (XAI); clinical translation in ophthalmology

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Clinical Diagnosis and Treatment of Otolaryngology Diseases

edited by Lichun Hsieh

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1360 | Submission Open

Keywords: otolaryngology; diagnostic imaging; minimally invasive surgery; precision medicine; head and neck diseases; clinical management

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostic Imaging and Interpretation in Pediatric Radiology

edited by

André Lollert

submission deadline 31 Dec 2026 | 3 articles | Viewed by 1296 | Submission Open

Keywords: pediatric radiology; pediatric MRI; pediatric CT; photon-counting CT; pediatric ultrasound; clinico-radiologic diagnostics; rare diseases; quantitative imaging; artificial intelligence; nuclear medicine

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Sarcoma Diagnostics: Histopathology, Imaging, and Artificial Intelligence for Precision Management

edited by

Siu Wai Choi

submission deadline 31 Dec 2026 | Viewed by 1274 | Submission Open

Keywords: sarcoma diagnosis and prognosis; machine learning models; genomics in diagnosis; classification and prognosis; novel methods of treatment

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Molecular Diagnostics in Cardiovascular Diseases: From Biomarkers to Individualized Medicine

edited by

Priyanka Gokulnath

and

Michail Spanos

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1263 | Submission Open

Keywords: molecular diagnostics; cardiovascular diseases; biomarkers; individualized medicine; precision cardiology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Inflammatory Pathways and Diagnostic Strategies in Chronic Diseases

edited by

Liliana-Georgeta Foia

Maria Alexandra Mârțu

and

Minerva Codruta Badescu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1196 | Submission Open

Keywords: chronic diseases; early diagnosis; non-invasive diagnosis; artificial intelligence application

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advanced Ultrasound Techniques in Diagnosis, Second Edition

edited by

Laith Riyadh Sultan

submission deadline 31 Dec 2026 | Viewed by 1132 | Submission Open

Keywords: super-resolution imaging; microvascular imaging (MVI); contrast-enhanced ultrasound; AI-guided ultrasound; quantitative analysis; diagnostic imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Update on Diagnosis in Cardiovascular Interventions

edited by

Alfredo E. Rodriguez

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1105 | Submission Open

Keywords: myocardial infarction; stents; coronary artery disease; drugs; coronary imaging; structural heart disease; meta-analysis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnosis and Management of Liver Diseases

edited by

Jiang Liu

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1009 | Submission Open

Keywords: primary liver cancer; metastatic liver cancer; liver transplantation; diagnosis; prognosis; biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Fetal Diagnosis and Therapy: 2nd Edition

edited by Elisa Montaguti and Camilla Dionisi

submission deadline 31 Dec 2026 | 1 articles | Viewed by 941 | Submission Open

Keywords: ultrasound; prenatal diagnosis; NIPT; fetal echocardiography; fetal therapy; fetal MRI

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advancements in Maternal–Fetal Medicine: 3rd Edition

edited by

Elena Bernad

submission deadline 31 Dec 2026 | Viewed by 918 | Submission Open

Keywords: maternal– fetal medicine; high-risk pregnancy; prenatal diagnostics; psychological distress in pregnancy; anxiety and depression; stress-related disorders; biomarkers; perinatal morbidity and mortality; translational diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Women’s Cardiovascular Health: Advances in Diagnosis, Screening, and Risk Prediction

edited by

Jasjit S. Suri

and

Luca Saba

submission deadline 31 Dec 2026 | 1 articles | Viewed by 905 | Submission Open

Keywords: artificial intelligence; women’ s cardiovascular health; diagnosis; screening; risk prediction

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Prostate Cancer: Innovations in Diagnosis and Risk Stratification

edited by Biren Saraiya

submission deadline 31 Dec 2026 | 1 articles | Viewed by 781 | Submission Open

Keywords: prostate cancer; diagnostics; therapeutics; molecular targets; Prostate Specific Membrane Antigen (PSMA); risk stratification; radioligand therapy; multimodal therapy; clinical guidelines

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Recent Advances in Oral and Maxillofacial Surgery: Diagnosis and Management

edited by Kenji Yamagata

submission deadline 31 Dec 2026 | 1 articles | Viewed by 732 | Submission Open

Keywords: oral and maxillofacial surgery; oral diseases; oral cancer; jaw deformity; orthognathic surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Emerging Technologies for Lung Disease Detection and Clinical Assessment

edited by Scott Matson and

Joshua Jay Reicher

submission deadline 31 Dec 2026 | 1 articles | Viewed by 563 | Submission Open

Keywords: medical imaging; artificial intelligence (AI); radiology; machine learning (ML)

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Advances in Orthodontics and Dentistry

edited by

Antonino Lo Giudice

submission deadline 31 Dec 2026 | 2 articles | Viewed by 472 | Submission Open

Keywords: CBCT facial scanning; oral imaging; orthodontics; digital dentistry; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Emerging Diagnostic Techniques and Therapeutic Strategies in Urological Oncology

edited by

Francesco Chierigo

submission deadline 31 Dec 2026 | Viewed by 451 | Submission Open

Keywords: prostate cancer; screening; biomarkers; genetic testing; imaging; PSMA; artificial intelligence; radical prostatectomy; radiotherapy; hormonal therapies

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Artificial Intelligence in Epidemiological Diagnostics: Advances and Applications

edited by

Jinhui Tian

submission deadline 31 Dec 2026 | Viewed by 448 | Submission Open

Keywords: artificial intelligence in diagnostic epidemiology; machine learning for diagnostic screening; predictive diagnostic modeling; automated diagnostic evidence synthesis; AI-designed peptides for diagnostics; antimicrobial peptide diagnostics; AI peptide engineering for pathogen detection; AI-driven population health diagnostics; diagnostic health informatics; digital diagnostic epidemiology

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Endoscopic Ultrasound: Diagnostic and Therapeutic Innovations

edited by

Andrada Seicean

submission deadline 31 Dec 2026 | Viewed by 365 | Submission Open

Keywords: endoscopic ultrasound (EUS); diagnostic and therapeutic innovations; minimally invasive interventions; EUS-guided tissue acquisition; advanced imaging techniques; multidisciplinary gastroenterology

(This special issue belongs to the Section Medical Imaging and Theranostics)

Deep Learning and Large Models in Ophthalmic Innovations

edited by

Yanwu Xu

Weihua Yang

and Huihui Fang

submission deadline 31 Dec 2026 | Viewed by 363 | Submission Open

Keywords: Artificial Intelligence in ophthalmology; multimodal learning; foundation models; ophthalmic imaging; eye disease diagnosis and treatment

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Pathogenesis, Diagnosis, and Management of Rheumatic Disease: Progress and Challenges

edited by Miguel Ángel González-Gay

submission deadline 31 Dec 2026 | Viewed by 359 | Submission Open

Keywords: rheumatic disease; systemic vasculitis; rheumatoid arthritis; metabolic syndrome; atherosclerosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Gastrointestinal Endoscopy: Diagnostic Applications and Safety Evaluation

edited by

Giacomo Emanuele Maria Rizzo

Lucía Guilabert

and Sara Nikolic

submission deadline 31 Dec 2026 | Viewed by 301 | Submission Open

Keywords: endoscopy; endoscopic ultrasound; luminal endoscopy; procedural safety; risk assessment; adverse events; sedation protocols

(This special issue belongs to the Section Medical Imaging and Theranostics)

Selected Papers From the 1st International Online Conference on Diagnostics [IOCDi 2026]

edited by

Giorgio Treglia

submission deadline 31 Dec 2026 | Viewed by 276 | Submission Open

Keywords: imaging diagnosis; pathology diagnosis; molecular diagnosis; clinical diagnosis; laboratory medicine; point-of-care diagnosis; artificial intelligence

Data Science and Artificial Intelligence in Laboratory Medicine

edited by

Fernando Marques-Garcia

submission deadline 31 Dec 2026 | Viewed by 263 | Submission Open

Keywords: artificial intelligence; data science; algorithm; laboratory medicine

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advances in the Diagnosis, Prognosis, and Management of the Musculoskeletal System

edited by

Massimiliano Leigheb

Alessandro de Sire

and Cesar de Cesar Netto

submission deadline 31 Dec 2026 | Viewed by 255 | Submission Open

Keywords: musculoskeletal system; diagnostic tools; prognosis; artificial intelligence; augmented reality

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Endoscopic Diagnosis and Management of Tumors

edited by

Longjun He

submission deadline 31 Dec 2026 | Viewed by 253 | Submission Open

Keywords: endoscopy; tumor diagnosis; endoscopic therapy; endoscopic ultrasound; artificial intelligence; early cancer detection; minimally invasive surgery; precision oncology; molecular imaging; translational research

(This special issue belongs to the Section Biomedical Optics)

Liquid Biopsy and Molecular Diagnostics in Neuro-Oncology

edited by Santiago Cabezas-Camarero and Juan Manuel Sepúlveda-Sánchez

submission deadline 31 Dec 2026 | Viewed by 239 | Submission Open

Keywords: liquid biopsy; biofluids; biomarkers; molecular techniques; gliomas; neuro-oncology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Cancer Diagnosis and Intervention

edited by Vlad Alexandru Gâta

submission deadline 31 Dec 2026 | Viewed by 229 | Submission Open

Keywords: diagnostic; precision oncology; artificial intelligence; radiomics; molecular biomarkers; interventional oncology; personalized medicine; translational research

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

From Early Diagnosis to Therapy Response: Machine Learning Driven Biomarker Discovery

edited by Wenjie Shi and Rudy Leon De Wilde

submission deadline 31 Dec 2026 | Viewed by 216 | Submission Open

Keywords: machine learning; biomarker discovery; early diagnosis; liquid biopsy; precision medicine

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Innovative Approaches to Vascular Diseases Diagnosis and Management

edited by

Paolo Perini

and

Chiara Martini

submission deadline 31 Dec 2026 | Viewed by 209 | Submission Open

Keywords: vascular imaging; vascular surgery; aortic aneurysm; peripheral arterial disease; venous disease; image-guided therapy; artificial intelligence; 3D printing; medical devices; vascular complications

(This special issue belongs to the Section Medical Imaging and Theranostics)

Precision Diagnostics in Renal Transplantation and Transplant Complications

edited by

Cheng Yang

submission deadline 31 Dec 2026 | Viewed by 192 | Submission Open

Keywords: renal transplantation; precision diagnostics; allograft rejection; non-invasive monitoring; biomarkers; multi-omics; kidney transplant complications; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Laboratory Diagnosis—2nd Edition

edited by

Giuseppe Lippi

and Camilla Mattiuzzi

submission deadline 31 Dec 2026 | Viewed by 183 | Submission Open

Keywords: laboratory diagnosis; biomarkers; clinical chemistry; laboratory analysis; artificial intelligence

(This special issue belongs to the Section Clinical Laboratory Medicine)

A New Era in Diagnosis: From Biomarkers to Artificial Intelligence, 2nd Edition

edited by

Tudor Drugan

and

Daniel Leucuta

submission deadline 31 Dec 2026 | Viewed by 183 | Submission Open

Keywords: biomarkers; diagnosis; personalized medicine; therapeutic strategies; artificial intelligence; machine learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in the Diagnosis, Prognosis, and Management of Urinary Disease—2nd Edition

edited by

Nicola Longo

and

Massimiliano Creta

submission deadline 31 Dec 2026 | Viewed by 166 | Submission Open

Keywords: urinary disease; diagnosis; prognosis; kidney disease; prostate disease; malignant diseases like kidney cancer; bladder cancer and prostate cancer

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnostics and Management in the ICU

edited by

Silvia De Rosa

and Sergio Lassola

submission deadline 31 Dec 2026 | Viewed by 165 | Submission Open

Keywords: intensive care unit; hemodynamic monitoring; acute kidney injury; sepsis and septic shock; clinical diagnostics; predictive biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Perspectives in the Diagnosis of Gastroenterological Diseases

edited by Reena Sidhu

submission deadline 31 Dec 2026 | Viewed by 152 | Submission Open

Keywords: small bowel; bleeding; Crohn’ s disease; endoscopy; coeliac disease; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Medical Microbiology and Infection: Diagnosis and Management

edited by Hsinyao Wang

submission deadline 31 Dec 2026 | Viewed by 145 | Submission Open

Keywords: medical microbiology; infectious diseases; diagnostic microbiology; infection management; antimicrobial susceptibility testing; non‑antibiotic therapies; clinical microbiology; diagnostic innovation

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Clinical Prognostic and Predictive Biomarkers, 4th Edition

edited by

Yuli Huang

and

Peisong Chen

submission deadline 31 Dec 2026 | Viewed by 143 | Submission Open

Keywords: biomarkers; prognostic; predictive; risk stratification; cardiovascular disease; diabetes; cancer; hypertension; heart failure

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Precision Diagnosis in Musculoskeletal Disorders: Current and Future Directions

edited by

Yuichi Yoshii

submission deadline 31 Dec 2026 | Viewed by 140 | Submission Open

Keywords: precision diagnosis; musculoskeletal imaging; artificial intelligence; quantitative imaging biomarkers; automated morphological analysis; predictive modeling; 3D patient-specific modeling; digital twin; image-guided diagnosis; personalized musculoskeletal care

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Accurate Diagnosis and Management of Infectious and Respiratory Diseases

edited by

Marco Goeijenbier

submission deadline 31 Dec 2026 | Viewed by 138 | Submission Open

Keywords: infectious and respiratory diseases; viral and bacterial pathogens; multiplex molecular panels; rapid diagnostic tests; intensive care units

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Whole-Body PET/CT: From Diagnosis to Prognosis

edited by Ioannis M. Tsougos

submission deadline 31 Dec 2026 | 1 articles | Viewed by 136 | Submission Open

Keywords: whole-body PET/CT; diagnosis; prognosis; human diseases; medical imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Precision Oncology: Integrating Histopathology, Immunohistochemistry, and Molecular Diagnostics

edited by

Tomonori Kawasaki

submission deadline 31 Dec 2026 | Viewed by 133 | Submission Open

Keywords: biomarker; cancer; carcinoma; cytology; diagnosis; fluorescence in situ hybridization; gene; growth factor receptor; histology; hormone receptor; immunohistochemistry; molecular pathology; neoplasm; next-generation sequencing; oncology; pathology; PCR; prognosis; treatment

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Lung Monitoring in Critical Care

edited by Lorenzo Ball

submission deadline 31 Dec 2026 | Viewed by 132 | Submission Open

Keywords: lung monitoring; critical care; mechanical ventilation; diagnosis; imaging

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Computed Tomography Imaging in Medical Diagnosis, Third Edition

edited by

Fabio Sandomenico

submission deadline 31 Dec 2026 | Viewed by 129 | Submission Open

Keywords: computed tomography; medical diagnosis; imaging; internal organs; bones; soft tissue; blood vessels

(This special issue belongs to the Section Medical Imaging and Theranostics)

Point-of-Care and At-Home Diagnostics for Infectious Diseases

edited by Gregory J. Tobin and Ke Du

submission deadline 31 Dec 2026 | Viewed by 127 | Submission Open

Keywords: infectious agents; at-home diagnostic; point-of-care diagnostic; pathogen surveillance; digital health; novel detection technologies; low-resource settings

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Advances in Diagnosis and Treatment of Thyroid Cancer

edited by

Chang Myeon Song

submission deadline 31 Dec 2026 | Viewed by 125 | Submission Open

Keywords: thyroid cancer; diagnosis; robotic thyroid surgery; thyroidectomy; molecular diagnostics; minimally invasive surgery; risk stratification; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Eye Disease, Fifth Edition

edited by

Jae-Ho Han

submission deadline 31 Dec 2026 | Viewed by 115 | Submission Open

Keywords: medical diagnosis; artificial intelligence; deep learning; fundus image; optical coherence tomography; ophthalmology; retinal vessel; glaucoma; retinopathy; macular degeneration; image segmentation

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Innovative Diagnostic Strategies for Inherited Metabolic Diseases

edited by Radha Ramachandran

submission deadline 31 Dec 2026 | Viewed by 106 | Submission Open

Keywords: inherited metabolic; diagnostic; prognostic monitoring; personalised genetic functional omics

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

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