Advances in the Detection and Screening of Gastric Cancer

Dear Colleagues,

The absolute number of new gastric cancer cases is expected to grow to 1.77 million in 2040 despite the decreasing overall incidence, therefore demonstrating the importance of this healthcare problem. The burden of the disease could be decreased either by spotting cancer at an early, ideally precancerous stage or by timely eradication of H. pylori infection, the major cause of gastric cancer. Screening for cancer via endoscopy or photophluoroscopy is included in nationwide programs in Japan and Korea, and a number of other countries are in the process of implementing preventive programs. This Special Issue is planned to summarize recent developments in the field.

Furthermore, non-invasive testing for gastric cancer or precancerous lesions has been at the focus of researchers for decades. In addition to traditional biomarkers, such as pepsinogens and gastrin-17, as well as markers for autoimmunity, the role of potential new approaches, including volatile organic compounds in breath, has shown promise. We intend to also address these issues in this issue by presenting the status of the ongoing studies.

Finally, large data and artificial intelligence are expected to change the mentality in medicine, including also in gastric-cancer-related aspects. We intend to identify the areas where data collaborations could facilitate efforts aimed at gastric cancer mortality reduction.

Therefore, with the current issue, we aim to present the current status in various aspects of gastric cancer screening and prevention and provide an update on screening programs, summary of the currently ongoing major studies globally, as well as give an opportunity to present original research results from groups active in the field.

Prof. Dr. Mārcis Leja
Guest Editor

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