Urologic Oncology: Clinical Diagnosis and Treatment

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2409

Special Issue Editors


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Guest Editor
Department of Urology, Clínico San Carlos Hospital, Health Research Institute of Clínico San Carlos Hospital, Complutense University, 28040 Madrid, Spain
Interests: urological oncology; robotics; functional urology
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Guest Editor
Department of Urology, Clínico San Carlos Hospital, Health Research Institute of Clínico San Carlos Hospital, Complutense University, 28040 Madrid, Spain
Interests: uro-oncology; prostate cancer; bladder cancer; kidney cancer; robotic surgery; laparoscopy; kidney transplant

Special Issue Information

Dear Colleagues,

Urologic oncology stands at the forefront of medical research and innovation. As advancements in technology and medical understanding continue to accelerate, the landscape of urologic oncology is undergoing profound transformations. Clinicians, researchers, and patients are now faced with an array of diagnostic tools, therapeutic approaches, and personalized treatment options, raising crucial questions about the most effective strategies used for diagnosis and treatment. This field encompasses a range of cancers, including (but not limited to) prostate, bladder, kidney, and testicular cancers, each presenting unique challenges and opportunities for medical intervention.

This Special Issue seeks to bridge the gap between cutting-edge research and its translation into optimal patient care. By scrutinizing the latest diagnostic techniques, exploring novel biomarkers, evaluating the efficacy of existing treatments, and investigating emerging therapies, this edition aims to highlight the path towards enhanced clinical outcomes and improved quality of life for patients grappling with urologic malignancies.

Dr. Jesús Moreno-Sierra
Dr. Juan Gómez Rivas
Guest Editors

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Keywords

  • diagnosis
  • prognosis
  • urological tumors
  • urological cancer
  • uro-oncology
  • prostate cancer
  • kidney cancer
  • bladder cancer
  • testicular cancer
  • penile cancer
  • screening
  • surgery
  • treatment

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Published Papers (2 papers)

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Review

12 pages, 236 KiB  
Review
The Role of Morcellation in En Bloc Resection of Large Bladder Tumors
by Nadav Dekel, Ekaterina Laukhtina, Andrey Morozov, Eva Compérat, Eddie Fridman, Shay Golan, Jeremy Yuen-Chun Teoh, Yossef Molchanov, Maxim Yakimov, Thomas R. W. Herrmann, Dmitry Pushkar, Jesús Moreno Sierra, Juan Gómez Rivas, Shahrokh F. Shariat and Dmitry Enikeev
Diagnostics 2025, 15(6), 716; https://doi.org/10.3390/diagnostics15060716 - 13 Mar 2025
Viewed by 485
Abstract
Background/Objectives: Conventional transurethral resection of bladder tumor (TURBT) for non-muscle invasive bladder cancer (NMIBC) is usually performed in a piecemeal manner, leading to difficulties in accurate pathological assessment. En bloc resection of bladder tumor (ERBT) has been developed to address these limitations, [...] Read more.
Background/Objectives: Conventional transurethral resection of bladder tumor (TURBT) for non-muscle invasive bladder cancer (NMIBC) is usually performed in a piecemeal manner, leading to difficulties in accurate pathological assessment. En bloc resection of bladder tumor (ERBT) has been developed to address these limitations, offering improved specimen quality. So far, ERBT has been restricted to small bladder tumors due to difficulties in en bloc extraction of large ones (>3 cm). Recently, the morcellation technique has been proposed to facilitate the removal of large bladder tumors during ERBT. This narrative review aims to evaluate the feasibility of ERBT with subsequent morcellation for large bladder tumors, focusing on its role in tumor extraction and its impact on pathological assessment. Methods: A comprehensive literature search was conducted across multiple databases to identify studies evaluating the use of morcellation in ERBT for large bladder tumors. Inclusion criteria comprised studies reporting recurrence rates, detrusor muscle (DM) presence in pathological specimens, and perioperative complications. Additionally, we offered uropathologists a questionnaire to gather their perspectives on the use of morcellation following ERBT, focusing on its impact on pathological assessment, margin evaluation, and staging accuracy. Results: While there is limited evidence on the use of morcellation in ERBT for tumors larger than 3 cm and its impact on oncologic outcomes, morcellation has shown potential in facilitating the retrieval of large tumor specimens, ensuring clear resection margins and accurate staging. However, the learning curve for morcellation techniques and the need for specialized equipment may limit widespread adoption. Conclusions: Morcellation in ERBT for large bladder tumors represents a promising advancement in the management of these challenging cases, offering adequate pathological assessment and oncologic outcomes. Pathologists’ reviews of morcellated specimens will likely further validate the technique. Continued research and technological innovations are necessary to optimize its implementation in clinical practice. Full article
(This article belongs to the Special Issue Urologic Oncology: Clinical Diagnosis and Treatment)
22 pages, 751 KiB  
Review
Blood-, Tissue- and Urine-Based Prognostic Biomarkers of Upper Tract Urothelial Carcinoma
by Jan Łaszkiewicz, Wojciech Krajewski, Aleksandra Sójka, Łukasz Nowak, Joanna Chorbińska, José Daniel Subiela, Wojciech Tomczak, Francesco Del Giudice, Bartosz Małkiewicz and Tomasz Szydełko
Diagnostics 2024, 14(17), 1927; https://doi.org/10.3390/diagnostics14171927 - 31 Aug 2024
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Abstract
Upper tract urothelial carcinoma (UTUC) is a rare but aggressive neoplasm. Currently, there are few reliable and widely used prognostic biomarkers of this disease. The purpose of this study was to assess the prognostic value of blood-, tissue- and urine-based biomarkers in patients [...] Read more.
Upper tract urothelial carcinoma (UTUC) is a rare but aggressive neoplasm. Currently, there are few reliable and widely used prognostic biomarkers of this disease. The purpose of this study was to assess the prognostic value of blood-, tissue- and urine-based biomarkers in patients with UTUC. A comprehensive literature search was conducted using the PubMed, Cochrane and Embase databases. Case reports, editorials and non-peer-reviewed literature were excluded from the analysis. As a result, 94 articles were included in this review. We evaluated the impact of 22 blood-based, 13 tissue-based and 4 urine-based biomarkers and their influence on survival outcomes. The neutrophil–lymphocyte ratio, albumin, C-reactive protein, De Ritis ratio, renal function and fibrinogen, which are currently mentioned in the European Association of Urology (EAU) guidelines, are well researched and most probably allow for a reliable prognosis estimate. However, our review highlights a number of other promising biomarkers that could potentially predict oncological outcomes in patients with UTUC. Nonetheless, the clinical value of some prognostic factors remains uncertain due to the lack of comprehensive studies. Full article
(This article belongs to the Special Issue Urologic Oncology: Clinical Diagnosis and Treatment)
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