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Diagnostics
Special Issues
Exploring the Role of Diagnostic Biochemistry, 2nd Edition
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Exploring the Role of Diagnostic Biochemistry, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1266

Special Issue Editors

Prof. Dr. Daria Pašalić

E-Mail Website
Guest Editor
Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Zagreb University School of Medicine, 10000 Zagreb, Croatia
Interests: clinical biochemistry; molecular diagnostics; genetics; epigenetics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Lidija Bilic-Zulle

E-Mail Website
Guest Editor
Clinical Department of Laboratory Diagnosis, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia
Interests: clinical biochemistry; health informatics; clinical laboratory science; laboratory analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,
The first edition of this Special Issue summarized current knowledge regarding the role of diagnostic biochemistry. Many interesting studies have provided new insights into clinical medicine. However, further studies are required, which prompted our decision to open submissions for the second edition of this Special Issue.

Biochemical testing is used in clinical medicine to obtain biochemical information in the treatment of patients. Information can only be used effectively in clinical decision making if it is accurate and appropriate and the physician recognizes its importance. Among other types of diagnostics, laboratory tests are included in almost 80% of clinical decisions. Therefore, patient safety must be ensured when performing these tests, with every effort made to avoid potential mistakes across the entire testing process. Biochemistry is therefore essential in the diagnosis and management of different disorders.

Prof. Dr. Daria Pašalić
Prof. Dr. Lidija Bilic-Zulle
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  •  laboratory tests in diagnosis, prognosis, monitoring, and treatment
  •  blood biomarkers in laboratory medicine
  •  extravascular body fluid biomarkers in laboratory medicine
  •  novel biomarkers in clinical biochemistry
  •  evidence-based laboratory medicine
  •  extra analytical phases and patient safety
  •  quality assurance and management in laboratory medicine

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Published Papers (1 paper)

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Research

14 pages, 239 KiB  
Article
Reference Intervals for Common Biochemistry and Hematology Parameters in Early Pregnancy—A Prospective Study
by Vesna Šupak-Smolčić, Lucija Franin, Dragana Antončić, Sabina Matejčić, Iva Vrdoljak-Colo, Sonja Homar, Mihovil Horvat and Lidija Bilić-Zulle
Diagnostics 2025, 15(4), 415; https://doi.org/10.3390/diagnostics15040415 - 8 Feb 2025
Viewed by 1137
Abstract
Background: The aim of this study was the determination of reference values for the common laboratory parameters in early pregnancy using a direct method and to assess their clinically significant difference, which was compared to the reference intervals for non-pregnant women with [...] Read more.
Background: The aim of this study was the determination of reference values for the common laboratory parameters in early pregnancy using a direct method and to assess their clinically significant difference, which was compared to the reference intervals for non-pregnant women with respect to the reference change value (RCV). Methods: This study was conducted from September 2022 to December 2023 at the Clinical Department of Laboratory Diagnostics, Clinical Hospital Centre RIJEKA, Croatia. The inclusion criteria were as follows: age ≥ 18 years, singleton pregnancy, normal ultrasound examination, and prenatal screening. The exclusion criteria were as follows: recent illness, pregnancy-related complications, medically assisted reproduction, and medication use. The reference intervals were established using the non-parametric percentile method according to the CLSI EP28-A3c recommendation. The reference values were compared to those of non-pregnant women and judged against RCV values based on biological variation. Additionally, we tested the influence of food consumption and oral supplements. Results: The data of 299 participants were included in the study. Laboratory tests whose changes are clinically relevant lower in early pregnancy are as follows: hemoglobin, MCV, hematocrit, MCH, urea, creatinine, albumin, alkaline phosphatase, lactate dehydrogenase, sodium, and magnesium. The clinically relevant higher values are as follows: RDW, total leukocyte count, neutrophil granulocytes, monocytes, CRP, total cholesterol, triglycerides, and amylase. UIBC has a wider reference range. The consumption of food and supplements has no clinically significant influence in relation to the RCV. Conclusions: Establishing reference intervals in pregnancy remains a challenge due to the metabolic changes during pregnancy, as well as its clinical significance. Full article
(This article belongs to the Special Issue Exploring the Role of Diagnostic Biochemistry, 2nd Edition)
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