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Diagnostics
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Advances in the Diagnosis and Management of Otopharyngeal Diseases
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Advances in the Diagnosis and Management of Otopharyngeal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 1760

Special Issue Editor

Dr. Boban M. Erovic

E-Mail Website
Guest Editor
Institute of Head and Neck Diseases, Evangelical Hospital Vienna, A-1180 Vienna, Austria
Interests: merkelcell carcinoma; head and neck cancer; ablative and reconstructive surgery

Special Issue Information

Dear Colleagues,

The head and neck area includes a significant number of structures that are eminent for nutrition, communication and respiration. The orofacial area is responsible for food intake and speech, followed by the orpharyngeal part that is important for swallowing and finally the larynx acting as the key structure for a free airway and voice production. Infectious diseases, acute or chronic, malformations or neoplasias affect significantly patients´ quality of life and lead to the need for a multidisciplinary diagnosis, treatment and finally rehabilitation. Research in this area of expertise is essential to fill gaps in knowledge and deliver complete and comprehensive patient care.

The purpose of this Special Issue is to investigate the current approaches and latest innovations to the diagnosis, management, and rehabilitation of patients with oropharyngeal diseases. Original research and review articles, case studies, reflective essays, commentaries, and research briefs are welcomed.

Dr. Boban M. Erovic
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

14 pages, 399 KiB  
Article
Carcinoma of Unknown Primary (CUP) versus CUP Turned to Primary Carcinoma of the Head and Neck—An Analysis of Diagnostic Methods and the Impact of Primary Tumor on Clinical Outcome
by Muhammad Faisal, Nguyen-Son Le, Stefan Grasl, Stefan Janik, Helmut Simmel, Annemarie U. Schratter-Sehn, Jafar-Sasan Hamzavi, Peter Franz and Boban M. Erovic
Diagnostics 2022, 12(4), 894; https://doi.org/10.3390/diagnostics12040894 - 03 Apr 2022
Cited by 4 | Viewed by 1461
Abstract
Background. The purpose of this study was to analyze the value of different diagnostic methods in detecting the primary site and the impact of primary tumors on the clinical outcome of carcinoma of unknown primary (CUP). Methods. In this multicenter, retrospective study, 124 [...] Read more.
Background. The purpose of this study was to analyze the value of different diagnostic methods in detecting the primary site and the impact of primary tumors on the clinical outcome of carcinoma of unknown primary (CUP). Methods. In this multicenter, retrospective study, 124 patients with true CUP (n = 94) and CUP turned to primary carcinoma (n = 30) were included. Patients with evidence of primary site during the clinical examination were excluded a priori. The diagnostic procedure was comprised of imaging and invasive methods (fine-needle-aspiration, tonsillectomy and panendoscopy). All patients were treated with curative intent. Results. Despite extensive diagnostic workup, the primary site remained unknown in 75.8%. Invasive diagnostic methods showed higher primary detection rates than imaging modalities (15.1% vs. 7.8%). Tonsillectomy and panendoscopy revealed the primary tumor in 14.9% and 15.2% of patients, whereas the detection rates of CT, MRI and FDG-PET-CT were 10.1%, 4.8% and 6.5%, respectively. The occurrence of primary tumors led to a significantly deteriorating 5-year overall survival (p = 0.002) and emerged as survival prognosticator (HR = 2.764, p = 0.003). Conclusion. Clinical examination in combination with tonsillectomy and panendoscopy was superior to imaging alone in detecting the primary tumor. When the CUP of patients turned to a primary tumor, clinical outcome was significantly worse than in CUP patients. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Otopharyngeal Diseases)
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