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Diagnostics
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Vulvovaginal Disorders: The Critical Role of Accurate Diagnosis to Effective...
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Vulvovaginal Disorders: The Critical Role of Accurate Diagnosis to Effective Management Strategies

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 117

Special Issue Editors

Dr. Orna Reichman

E-Mail Website
Guest Editor
Department of Obstetrics and Gynaecology, Shaare Zedek Medical Centre, Hebrew University, Jerusalem, Israel
Interests: maternal and neonatal medicine; obstetrics and gynecology; infection
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jack Sobel

E-Mail Website
Guest Editor
School of Medicine, Wayne State University, Detroit, MI 48201, USA
Interests: internal medicine; immunology and microbiology; obstetrics and gynecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, "Vulvovaginal Disorders: The Critical Role of Accurate Diagnosis to Effective Management Strategies", delves into the intricacies of vulvovaginal health, emphasizing the pivotal significance of precise diagnosis in formulating successful treatment plans. It explores the latest advancements in diagnostic techniques, including innovative imaging, molecular testing, and clinical assessments, that enhance our understanding of these disorders. By highlighting the importance of early and accurate identification, this Special Issue aims to empower healthcare professionals with the knowledge and tools that are necessary to effectively manage and alleviate the symptoms associated with vulvovaginal conditions.

Dr. Orna Reichman
Prof. Dr. Jack Sobel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnosis
  • screening
  • marker
  • prognosis
  • vulvovaginal disorders
  • pathology
  • theranostics

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Published Papers (1 paper)

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Review

14 pages, 1788 KiB  
Review
Hallmarks of Bacterial Vaginosis
by Diana Cristina Pérez-Ibave, Carlos Horacio Burciaga-Flores, Ximena García-Mejía, Fernando Alcorta-Nuñez, Orlando Solis-Coronado, Moisés González Escamilla, Oscar Vidal-Gutiérrez and María Lourdes Garza-Rodríguez
Diagnostics 2025, 15(9), 1090; https://doi.org/10.3390/diagnostics15091090 - 25 Apr 2025
Viewed by 218
Abstract
Background: Bacterial vaginosis (BV) is considered the most common cause of vaginal discharge, which is related to several public health issues, such as an increased risk for sexually transmitted infections, pelvic inflammatory disease, pregnancy-related problems such as abortion, stillbirth or premature birth, and [...] Read more.
Background: Bacterial vaginosis (BV) is considered the most common cause of vaginal discharge, which is related to several public health issues, such as an increased risk for sexually transmitted infections, pelvic inflammatory disease, pregnancy-related problems such as abortion, stillbirth or premature birth, and tubal factor infertility. BV is not considered an infection but an imbalance in the vaginal microbiota, characterized by a substitution of the normal Lactobacilli flora by anaerobe. Reducing resistance against infections by several mechanisms, including bacterial homeostasis, stabilization of acid pH, inhibition of pathogens adhesion by polyamine degradation, production of anti-inflammatory molecules, surfactants, and antimicrobial substances like hydrogen peroxide, acids, and bacteriocins. Approximately half of women with BV can experience symptoms, which mainly include vaginal malodor, fishy discharge, stinging sensation, and increased vaginal pH. The treatment of BV is based primarily on promoting Lactobacilli restoration and eliminating dangerous microbiota with antibiotic therapy. However, there is a high rate of recurrence and relapse. Objective: Based on the current literature, this review aims to propose a list of ten BV hallmarks: dysbiosis, inflammation, apoptosis, pH basification, mucosal barrier integrity, pathway activation, epithelial damage, genomic instability, oxidative stress (OS), and metabolic reconfiguration. Conclusions: Understanding the causes of BV and the pathogenicity mechanisms is critical for preventing and improving the current therapeutic management of patients. Full article
(This article belongs to the Special Issue Vulvovaginal Disorders: The Critical Role of Accurate Diagnosis to Effective Management Strategies)
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