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Diagnostics
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Ultrasound Imaging in Medicine in 2025
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Ultrasound Imaging in Medicine in 2025

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 2758

Special Issue Editor

Prof. Dr. Michael Bachmann Nielsen

E-Mail Website
Guest Editor
Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
Interests: diagnostic radiology; cancer imaging; medical ultrasound; Doppler techniques; CT-scanning; medical presentations; musculoskeletal imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ultrasound examinations are performed within almost all medical specialties and are of paramount value in clinical medicine and as research tools. Diagnostic ultrasounds as well as ultrasound guidance for biopsy, drainage, and tumor ablation have become an integral part of the clinical setting. The last ten years have seen an increase in new ultrasound techniques such as contrast-enhanced ultrasound (CEUS), elastography techniques, 3D ultrasound, image fusion with ultrasound, and methods for flow visualization such as the vector Doppler method. In terms of the technical aspects, transducer technology has also evolved tremendously. This Special Issue invites submissions of both original and review papers as well as technical and clinical papers pertaining to all aspects of ultrasound imaging.

Prof. Dr. Michael Bachmann Nielsen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D ultrasound
  • blood flow velocity
  • ultrasonography
  • contrast-enhanced ultrasound
  • elasticity imaging
  • endoscopic ultrasound
  • intervention

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Published Papers (2 papers)

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Research

10 pages, 760 KB  
Article
Median Nerve Diameter Ratio on Ultrasound as a Complementary Tool to Electrodiagnostic Testing in Carpal Tunnel Syndrome
by Thorsten Lehnhardt, Christian Soost, Jan Adriaan Graw, Rene Burchard, Christopher Bliemel and Artur Barsumyan
Diagnostics 2025, 15(19), 2464; https://doi.org/10.3390/diagnostics15192464 - 26 Sep 2025
Viewed by 275
Abstract
Background: Carpal tunnel syndrome is a common entrapment neuropathy of the upper limb that has a significant clinical and socioeconomic impact. Sonographic short-axis measurement of the median nerve cross-sectional area is a well-established complement to clinical examination and neurography. This study aimed [...] Read more.
Background: Carpal tunnel syndrome is a common entrapment neuropathy of the upper limb that has a significant clinical and socioeconomic impact. Sonographic short-axis measurement of the median nerve cross-sectional area is a well-established complement to clinical examination and neurography. This study aimed to evaluate the correlation between the median nerve diameter ratio, distal motor latency, and sensory nerve conduction velocity. Methods: A total of 74 patients (94 hands and 93 evaluations) with carpal tunnel syndrome were examined. Ultrasound was performed using a Siemens Acuson X300 with a 10 MHz linear probe. Median nerve diameters proximal and within the carpal tunnel were measured in a longitudinal scan. The carpal tunnel ratio (proximal diameter/intratunnel diameter) was then calculated and correlated with distal motor latency. Results: No significant correlation was found between distal motor latency and the carpal tunnel ratio (r = 0.018, p = 0.8655). However, a weak, non-significant positive correlation was observed between sensory nerve conduction velocity and carpal tunnel ratio (r = 0.238, p = 0.326). Conclusions: Ultrasound cannot replace electrodiagnostic testing. In this cohort, no statistically significant association was observed between the carpal tunnel ratio and distal motor latency. While our findings do not support the use of this ultrasound parameter as a standalone diagnostic measure, sonographic assessment of the median nerve may still provide complementary information in selected clinical contexts. Full article
(This article belongs to the Special Issue Ultrasound Imaging in Medicine in 2025)
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20 pages, 2681 KB  
Article
Analysing the Renal Vasculature Using Super-Resolution Ultrasound Imaging: Considerations for Clinical and Research Applications
by Amy McDermott, Nathalie Sarup Panduro, Iman Taghavi, Hans Martin Kjer, Stinne Byrholdt Søgaard, Michael Bachmann Nielsen, Jørgen Arendt Jensen and Charlotte Mehlin Sørensen
Diagnostics 2025, 15(12), 1515; https://doi.org/10.3390/diagnostics15121515 - 14 Jun 2025
Cited by 1 | Viewed by 897
Abstract
Background: Vascular imaging is essential for clinical practice, research, and the diagnosis and management of vascular diseases. Super-resolution ultrasound (SRUS) imaging is an emerging high-resolution imaging technique with broad applications in soft tissue vascular imaging. However, the impact of biological and clinical variables [...] Read more.
Background: Vascular imaging is essential for clinical practice, research, and the diagnosis and management of vascular diseases. Super-resolution ultrasound (SRUS) imaging is an emerging high-resolution imaging technique with broad applications in soft tissue vascular imaging. However, the impact of biological and clinical variables on its imaging accuracy is currently unknown. This study investigates these factors in an animal model and compares SRUS with contrast-enhanced µCT. Methods: Kidney scans from 29 Zucker rats (Zucker Diabetic Fatty and Zucker Lean) were retrospectively analysed. The left kidney was imaged in vivo using SRUS during microbubble infusion, then filled with Microfil and excised for ex vivo µCT. SRUS parameters and clinical variables were analysed, and SRUS scans were co-registered with µCT to compare vascular density measurements. Results: Mean arterial blood pressure and anaesthesia time showed significant linear relationships with SRUS microbubble detection and vascular track reconstruction. The anaesthesia time was also strongly correlated with vascular density measurement. Visualisation and velocity estimations of renal arteries were limited with SRUS. Ultrasound signal attenuation had significant impacts, particularly in cortical far-field imaging. Despite differences between kidney regions, the vascular density distribution did not differ considerably between SRUS and µCT datasets for whole-kidney imaging. Conclusions: This study outlines key factors SRUS users must consider for optimal technique use. Careful region selection and control of clinical variables ensure more reliable and comparable images. Further research is necessary to translate these findings from a rat model into clinical application. Full article
(This article belongs to the Special Issue Ultrasound Imaging in Medicine in 2025)
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