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Diagnostics
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Clinical Advances in Diagnostics and Management of Cardiovascular Diseases, 2nd...
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Clinical Advances in Diagnostics and Management of Cardiovascular Diseases, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3132

Special Issue Editors

Dr. Jan Fedacko

E-Mail Website
Guest Editor
Centre of Clinical and Preclinical Research MEDIPARK, Faculty of Medicine, Pavol Jozef Safarik University, 040-11 Kosice, Slovakia
Interests: preventive cardiology; echocardiography; lipidology; coronary artery disease; epidemiology of CVDs
Special Issues, Collections and Topics in MDPI journals
Dr. Ghizal Fatima

E-Mail Website
Guest Editor
Department of Biotechnology, Era's Lucknow Medical College and Hospital, Lucknow 226003, India
Interests: biochemistry and pathophysiology of CVDs; atherosclerosis, CV biomarkers, epidemiology of CVDs

Special Issue Information

Dear Colleagues,

Following the success of the first edition of the Special Issue “Clinical Advances in Diagnostics and Management of Cardiovascular Diseases”, we are pleased to announce a second edition.

Cardiovascular diseases (CVDs) are the number one cause of death globally, claiming an estimated 17.9 million lives each year (WHO).

The main aim of this Special Issue of Diagnostics is to showcase new advances in the diagnosis and prevention of CVDs and new/innovative management strategies for CVD patients. This Special Issue is open to submissions covering a new range of biomarkers (not only blood biomarkers), methodologies, strategies, diagnostics modalities, and technologies. Advanced technologies, such as artificial intelligence/machine learning, used in the field of CVDs diagnostics or prevention are also of interest.

The aim of this Special Issue is to deliver new insight into the possibility of early detection of CVDs, which could lead to a decrease in morbidity and mortality. Papers focused on the early identification of subclinical atherosclerosis or coronary artery disease are strongly encouraged.

Authors can submit communications, reviews, and original articles addressing the field of CVDs. We welcome submissions of clinical, translational, and basic research.

Dr. Jan Fedacko
Dr. Ghizal Fatima
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular diseases
  • biomarkers
  • cardiac imaging
  • echocardiography
  • prevention of cardiovascular diseases
  • advanced diagnostics of cardiovascular diseases
  • coronary artery disease
  • dyslipidemia
  • heart failure
  • arrhythmia
  • stroke
  • nutritional supplements
  • epidemiology of CVDs

Published Papers (2 papers)

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Review

18 pages, 4711 KiB  
Review
Arterial Stiffness as a Surrogate Marker of Cardiovascular Disease and Atherosclerosis in Patients with Vasculitides: A Literature Review
by Konstantinos Triantafyllias, Leif-Erik Thiele, Anna Mandel, Lorenzo Cavagna, Xenofon Baraliakos, George Bertsias, Rebecca Hasseli, Pascal Minnich and Andreas Schwarting
Diagnostics 2023, 13(24), 3603; https://doi.org/10.3390/diagnostics13243603 - 05 Dec 2023
Viewed by 1029
Abstract
Vasculitis, a group of systemic inflammatory diseases that affect the cardiovascular (CV) system, presents with a variety of clinical manifestations that depend on the size of the affected blood vessels. While some types of vasculitis reveal distinct symptoms, others are characterized by more [...] Read more.
Vasculitis, a group of systemic inflammatory diseases that affect the cardiovascular (CV) system, presents with a variety of clinical manifestations that depend on the size of the affected blood vessels. While some types of vasculitis reveal distinct symptoms, others are characterized by more diffuse and nonspecific presentations that can result in delayed diagnosis and treatment initiation. Interestingly, patients with vasculitides share a significant comorbidity: an elevated CV risk, contributing to increased rates of CV events and mortality. This heightened risk is caused by cumulative inflammatory burden, traditional CV risk factors, medication effects, and reduced physical fitness. Traditional risk assessment tools, commonly used in the general population, frequently underestimate the CV risk in patients with inflammatory rheumatic conditions. Consequently, novel approaches are necessary to stratify the precise CV risk in vasculitis patients. A number of surrogate parameters for CV risk have been investigated, with arterial stiffness emerging as a promising marker. Pulse wave velocity (PWV) is a well-established method for assessing arterial stiffness and predicting CV risk across different populations. Among numerous PWV variants, carotid–femoral PWV (cfPWV) stands out as the most extensively studied and accepted reference standard. It has demonstrated its utility as a surrogate CV parameter both in the general population and in patients with systemic inflammatory rheumatic diseases. In recent years, research has expanded to assess arterial stiffness in systemic rheumatic diseases, such as arthritis, connective tissue diseases, rheumatologic overlap syndromes, and chronic pain disorders, using measurements of PWV and other markers of arterial compliance and elasticity. Despite burgeoning research in rheumatologic diseases, data on CV risk markers in vasculitides remain limited and fragmented. This narrative review aims to provide a comprehensive overview of arterial stiffness as a potential screening marker for CV diseases, atheromatosis, and ultimately CV risk among patients with vasculitides. Full article
(This article belongs to the Special Issue Clinical Advances in Diagnostics and Management of Cardiovascular Diseases, 2nd Edition)
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17 pages, 668 KiB  
Review
Cardiac Biomarkers and Their Role in Identifying Increased Risk of Cardiovascular Complications in COVID-19 Patients
by Nagendra Yaluri, Alena Stančáková Yaluri, Pavol Žeňuch, Zuzana Žeňuchová, Štefan Tóth and Peter Kalanin
Diagnostics 2023, 13(15), 2508; https://doi.org/10.3390/diagnostics13152508 - 27 Jul 2023
Cited by 4 | Viewed by 1531
Abstract
Cardiovascular disease (CVD) is a global health concern, causing significant morbidity and mortality. Both lifestyle and genetics influence the development of CVD. It is often diagnosed late, when the treatment options are limited. Early diagnosis of CVD with help of biomarkers is necessary [...] Read more.
Cardiovascular disease (CVD) is a global health concern, causing significant morbidity and mortality. Both lifestyle and genetics influence the development of CVD. It is often diagnosed late, when the treatment options are limited. Early diagnosis of CVD with help of biomarkers is necessary to prevent adverse outcomes. SARS-CoV-2 infection can cause cardiovascular complications even in patients with no prior history of CVD. This review highlights cardiovascular biomarkers, including novel ones, and their applications as diagnostic and prognostic markers of cardiovascular complications related to SARS-CoV-2 infection. Patients with severe SARS-CoV-2 infection were shown to have elevated levels of cardiac biomarkers, namely N-terminal pro-brain natriuretic peptide (NT-pro-BNP), creatine kinase-myocardial band (CK-MB), and troponins, indicating acute myocardial damage. These biomarkers were also associated with higher mortality rates and therefore should be used throughout COVID-19 patient care to identify high-risk patients promptly to optimize their outcomes. Additionally, microRNAs (miRNAs) are also considered as potential biomarkers and predictors of cardiac and vascular damage in SARS-CoV-2 infection. Identifying molecular pathways contributing to cardiovascular manifestations in COVID-19 is essential for development of early biomarkers, identification of new therapeutic targets, and better prediction and management of cardiovascular outcomes. Full article
(This article belongs to the Special Issue Clinical Advances in Diagnostics and Management of Cardiovascular Diseases, 2nd Edition)
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