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Diagnostics
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Eosinophilic Gastrointestinal Disorders: Advances in Diagnosis and Management
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Eosinophilic Gastrointestinal Disorders: Advances in Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2194

Special Issue Editors

Dr. Amir Mari

E-Mail Website
Guest Editor
1. Gastroenterology Unit, Nazareth EMMS Hospital, Nazareth, Israel
2. The Azrieli Faculty of Medicine, Bar Ilan University, Ramat Gan, Israel
Interests: esophageal disease; neurogastroenterology; esophageal diagnostics; gastrointestinal conditions; infectious diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Edoardo V. Savarino

E-Mail Website
Guest Editor
Department of Surgery, Oncological and Gastrointestinal Science, University of Padova, 35121 Padova, Italy
Interests: neurogastroenterology; inflammatory bowel diseases; irritable bowel syndrome; eosinophilic gastrointestinal disorders; gastroesophageal reflux disease; esophageal motility disorders; disorders of the gut–brain axis; microbiome; microbiota transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Eosinophilic gastrointestinal disorders are a group of disorders characterized by the pathologic eosinophilic infiltration of various organs of the gastrointestinal tract, the esophagus, stomach, small intestine, and the colon. Pathological eosinophilic infiltration may cause symptoms such as dysphagia, food impaction, dyspepsia, abdominal pain, diarrhea, heartburn, abdominal pain, and vomiting in children. These disorders are considered immune-mediated chronic inflammatory disorders with strong links to food allergen triggers. Recent years have witnessed significant advances in basic science research, clinical diagnosis, and the management of eosinophilic gastrointestinal disorders. Treatment strategies focus on either medical or dietary therapy. The main aim of this Special Issue is to shed light on the clinical presentation, pathophysiology, diagnosis, and treatment of these increasingly recognized disorders.

Dr. Amir Mari
Dr. Edoardo V. Savarino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • eosinophilic esophagitis
  • diagnosis
  • treatment
  • histology
  • epidemiology
  • risk factors
  • endoscopy
  • high resolution manometry
  • dietary therapy

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Published Papers (1 paper)

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20 pages, 1503 KiB  
Review
The Dynamic Evolution of Eosinophilic Esophagitis
by Amir Farah, Tarek Assaf, Jawad Hindy, Wisam Abboud, Mostafa Mahamid, Edoardo Vincenzo Savarino and Amir Mari
Diagnostics 2025, 15(3), 240; https://doi.org/10.3390/diagnostics15030240 - 21 Jan 2025
Viewed by 1968
Abstract
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory condition of the esophagus characterized by eosinophilic infiltration, and hallmark symptoms of esophageal dysfunction such as dysphagia and food impaction. Over the past three decades, EoE has been recognized as a distinct clinical entity, distinguished [...] Read more.
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory condition of the esophagus characterized by eosinophilic infiltration, and hallmark symptoms of esophageal dysfunction such as dysphagia and food impaction. Over the past three decades, EoE has been recognized as a distinct clinical entity, distinguished from gastroesophageal reflux disease (GERD) through advancements in diagnostic techniques, particularly endoscopy with biopsy. The rising global prevalence of EoE reflects enhanced diagnostic awareness, evolving criteria, and environmental along with lifestyle changes. The etiology of EoE is multifactorial, involving genetic predispositions, immune dysregulation, the gut microbiome, and environmental triggers, including dietary allergens and aeroallergens. Key mechanisms include a type 2 helper T-cell (Th2)-driven immune response, epithelial barrier dysfunction, and genetic variants such as CAPN14 and TSLP. Chronic inflammation leads to tissue remodeling, fibrosis, and esophageal narrowing, contributing to disease progression and complications. Management strategies have evolved to include dietary elimination, proton pump inhibitors, topical corticosteroids, biologics, and endoscopic interventions for fibrostenotic complications. Emerging therapies targeting cytokines such as interleukin (IL)-4, IL-5, and IL-13, alongside novel diagnostic tools like the esophageal string test and Cytosponge, offer promising avenues for improved disease control and non-invasive monitoring. Long-term surveillance combining endoscopic and histological evaluations with biomarkers and non-invasive tools is critical to optimizing outcomes and preventing complications. Future research should address gaps in understanding the role of the esophageal microbiome, refine therapeutic approaches, and develop personalized strategies to improve disease management and patient quality of life. Full article
(This article belongs to the Special Issue Eosinophilic Gastrointestinal Disorders: Advances in Diagnosis and Management)
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