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Diagnostics
Special Issues
Endometriosis, Adenomyosis and Gynecologic Cancer: Diagnosis and Management
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Endometriosis, Adenomyosis and Gynecologic Cancer: Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 16377

Special Issue Editor

Prof. Dr. Ovidiu Simion Cotoi

E-Mail Website
Guest Editor
1. Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mures, 540139 Targu Mures, Romania
2. Pathology Department, Mures Clinical County Hospital, 540142 Targu Mures, Romania
Interests: dermatopathology; melanoma; tumor markers; immunohistochemistry; molecular pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometriosis and adenomyosis are complex diseases with economic implications that cause abdominal and pelvic pain, infertility, dyspareunia and decreased quality of life.

There is evidence that endometriosis is associated with some cancer types, carcinomas and sarcomas, though cancer risk in patients with adenomyosis is currently rarely examined.

The diagnosis and management of endometriosis and adenomyosis and the determination of their malignancy require tools with high sensitivity and specificity. New sensitive, specific, accurate and reliable technologies that can be implemented using high-throughput mechanisms are essential.

For this Special Issue, we encourage authors to contribute manuscripts that describe the current state of research on endometriosis and adenomyosis and predictive factors for their malignancy, with a focus on similarities in the patterns of behavior and pathogenesis of endometriosis and cancers. Additionally, studies of clinical, molecular, imaging, genetic and histopathological markers for better prediction of malignant transformation in endometriosis or adenomyosis, as well as discussions of how those markers can be used in clinical practice and in therapy, are encouraged.

Many thanks.

Prof. Dr. Ovidiu Simion Cotoi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis

  • adenomyosis
  • pathophysiology
  • biomarkers
  • gynecological cancer
  • infertility
  • medical treatment
  • targeted therapy
  • imaging
  • minimally invasive surgery

Published Papers (2 papers)

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Review

17 pages, 896 KiB  
Review
Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature
by Ioan Emilian Oală, Melinda-Ildiko Mitranovici, Diana Maria Chiorean, Traian Irimia, Andrada Ioana Crișan, Ioana Marta Melinte, Teodora Cotruș, Vlad Tudorache, Liviu Moraru, Raluca Moraru, Laura Caravia, Mihai Morariu and Lucian Pușcașiu
Diagnostics 2024, 14(3), 312; https://doi.org/10.3390/diagnostics14030312 - 31 Jan 2024
Viewed by 1348
Abstract
Endometriosis is a chronic inflammatory disease, which explains the pain that such patients report. Currently, we are faced with ineffective, non-invasive diagnostic methods and treatments that come with multiple side effects and high recurrence rates for both the disease and pain. These are [...] Read more.
Endometriosis is a chronic inflammatory disease, which explains the pain that such patients report. Currently, we are faced with ineffective, non-invasive diagnostic methods and treatments that come with multiple side effects and high recurrence rates for both the disease and pain. These are the reasons why we are exploring the possibility of the involvement of pro-inflammatory and anti-inflammatory molecules in the process of the appearance of endometriosis. Cytokines play an important role in the progression of endometriosis, influencing cell proliferation and differentiation. Pro-inflammatory molecules are found in intrafollicular fluid. They have an impact on the number of mature and optimal-quality oocytes. Endometriosis affects fertility, and the involvement of endometriosis in embryo transfer during in vitro fertilization (IVF) is being investigated in several studies. Furthermore, the reciprocal influence between anti-inflammatory and pro-inflammatory cytokines and their role in the pathogenesis of endometriosis has been assessed. Today, we can affirm that pro-inflammatory and anti-inflammatory cytokines play roles in survival, growth, differentiation, invasion, angiogenesis, and immune escape, which provides a perspective for approaching future clinical implications and can be used as biomarkers or therapy. Full article
(This article belongs to the Special Issue Endometriosis, Adenomyosis and Gynecologic Cancer: Diagnosis and Management)
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13 pages, 764 KiB  
Review
Adenomyosis and Its Possible Malignancy: A Review of the Literature
by Liviu Moraru, Melinda-Ildiko Mitranovici, Diana Maria Chiorean, Raluca Moraru, Laura Caravia, Andreea Taisia Tiron and Ovidiu Simion Cotoi
Diagnostics 2023, 13(11), 1883; https://doi.org/10.3390/diagnostics13111883 - 28 May 2023
Cited by 2 | Viewed by 13303
Abstract
Cancer arising from adenomyosis is very rare, with transformation occurring in only 1% of cases and in older individuals. Adenomyosis, endometriosis and cancers may share a common pathogenic mechanism that includes hormonal factors, genetic predisposition, growth factors, inflammation, immune system dysregulation, environmental factors [...] Read more.
Cancer arising from adenomyosis is very rare, with transformation occurring in only 1% of cases and in older individuals. Adenomyosis, endometriosis and cancers may share a common pathogenic mechanism that includes hormonal factors, genetic predisposition, growth factors, inflammation, immune system dysregulation, environmental factors and oxidative stress. Endometriosis and adenomyosis both exhibit malignant behaviour. The most common risk factor for malignant transformation is prolonged exposure to oestrogens. The golden standard for diagnosis is histopathology. Colman and Rosenthal emphasised the most important characteristics in adenomyosis-associated cancer. Kumar and Anderson emphasised the importance of demonstrating a transition between benign and malignant endometrial glands in cancer arising from adenomyosis. As it is very rare, it is difficult to standardize treatment. In this manuscript, we try to emphasize some aspects regarding the management strategy, as well as how heterogenous the studies from the literature are in terms of prognosis in both cancers that develop from adenomyosis or those that are only associated with adenomyosis. The pathogenic mechanisms of transformation remain unclear. As these types of cancer are so rare, there is no standardised treatment. A novel target in the diagnosis and treatment of gynaecological malignancies associated with adenomyosis is also being studied for the development of new therapeutic concepts. Full article
(This article belongs to the Special Issue Endometriosis, Adenomyosis and Gynecologic Cancer: Diagnosis and Management)
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