Advances in Diagnosis and Management of Urological Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 2816

Special Issue Editors


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Guest Editor
Department of Analytical Instruments Group, Thermo Fisher Scientific, 82110 Germering, Germany
Interests: disease biomarkers; proteomics; mass spectrometry; analytical chemistry; diagnosis; systems biology; clinical applications; personalized medicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Medical Health Services / In Vitro Diagnostics, TÜV SÜD Product Service GmbH, Hamburg, Germany
Interests: clinical proteomics; molecular diagnostics; companion diagnostics; assay development; multimarker modeling; molecular network analysis; systems biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The management of critically ill patients is of utmost importance. Urological diseases contribute to a significant decline in life quality, especially when the disease is diagnosed at a late stage, providing limited options for health improvement. Advanced stages of the disease progression are often critical, so prompt diagnosis is crucial for preventing such outcomes. The characterization of novel and more accurate clinical markers will allow on-time capture of disease onset, avoiding urinary track system deterioration. Proteins and other biomolecules provide a great opportunity to monitor the disease on a molecular level. Changes in these molecular features are pivotal for the expression of molecular pathways and disease pathogenesis. High-throughput technology for biomarker discovery, validation, and drug development is required for improved risk stratification, better and more cost-effective medical care, and advanced personalized medicine. In line with those strategies, this Special Issue of Diagnostics will be devoted to the latest development of up-to-date studies and findings in the area of urological disease that could be translated into clinical practice for prospective patient management.

We invite scientists to submit articles presenting new achievements in urological diseases. We very much look forward to your submission.

Dr. Martin Pejchinovski
Dr. Jochen Metzger
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • proteomics
  • biomarkers
  • diagnosis
  • prediction
  • treatment
  • clinical application
  • technical advances

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Published Papers (1 paper)

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Review

16 pages, 1488 KiB  
Review
The Role of Oxidative Stress as a Mechanism in the Pathogenesis of Acute Heart Failure in Acute Kidney Injury
by Danijela Tasić and Zorica Dimitrijević
Diagnostics 2024, 14(18), 2094; https://doi.org/10.3390/diagnostics14182094 - 23 Sep 2024
Cited by 1 | Viewed by 2208
Abstract
Despite a large amount of research on synchronous and mutually induced kidney and heart damage, the basis of the disease is still not fully clarified. Healthy mitochondria are essential for normal kidney and heart function. Mitochondrial dysfunction occurs when the clearance or process [...] Read more.
Despite a large amount of research on synchronous and mutually induced kidney and heart damage, the basis of the disease is still not fully clarified. Healthy mitochondria are essential for normal kidney and heart function. Mitochondrial dysfunction occurs when the clearance or process of generation and fragmentation of mitochondria is disturbed. The kidney is the second organ after the heart in terms of the number of mitochondria. Kidney tubules are rich in mitochondria due to the high energy requirements for absorption of large amounts of ultrafiltrate and dissolved substances. The place of action of oxidative stress is the influence on the balance in the production and breakdown of the mitochondrial reactive oxygen species. A more precise determination of the place and role of key factors that play a role in the onset of the disease is necessary for understanding the nature of the onset of the disease and the creation of therapy in the future. This underscores the urgent need for further research. The narrative review integrates results found in previously performed studies that have evaluated oxidative stress participation in cardiorenal syndrome type 3. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Management of Urological Diseases)
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