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Diagnostics
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Endoscopic Diagnostics for Pancreatobiliary Disorders 2025
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Endoscopic Diagnostics for Pancreatobiliary Disorders 2025

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1225

Special Issue Editor

Dr. Masataka Kikuyama

E-Mail Website
Guest Editor
Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan
Interests: imaging diagnosis of early-stage pancreatic cancer; including carcinoma in situ; imaging diagnosis of biliary diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endoscopic diagnostics for gastrointestinal cancer have greatly advanced alongside endoscopic apparatus development, improving the prognosis of patients with gastrointestinal cancer. These techniques, however, are only just starting to be developed for pancreatobiliary disorders, including cancer, with pancreatic cancer prognosis remaining extremely poor. The main radiologic methods used to diagnose pancreatobiliary disorders are CT and MRI, despite their limitations; however, endoscopic ultrasonography (EUS) and endoscopic retrograde pancreatocholangiography (ERCP) have started to play a role in newly developed methods such as EUS fine-needle aspiration (EUS-FNA) or serial pancreatic juice aspiration cytologic examination (SPACE). This Special Issue aims to clarify the role played by endoscopic methods in diagnosing pancreatobiliary disorders.

Dr. Masataka Kikuyama
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endoscopic ultrasonography
  • endoscopic retrograde cholangiopancreatography
  • EUS–FNA
  • SPACE
  • pancreatic cancer
  • bile duct caner
  • gallbladder cancer

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Published Papers (2 papers)

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Research

13 pages, 2158 KiB  
Article
Efficacy and Safety of Percutaneous Transhepatic Lithotripsy Using SpyGlassDSTM Cholangioscopy for the Treatment of Difficult Stones
by Salvatore Alessio Angileri, Giuseppe Pellegrino, Carolina Lanza, Jacopo Pozzi, Marco Costa, Matilde Pavan, Pierpaolo Biondetti, Serena Carriero, Velio Ascenti, Gaetano Valerio Davide Amato, Pierluca Torcia, Anna Maria Ierardi and Gianpaolo Carrafiello
Diagnostics 2025, 15(9), 1060; https://doi.org/10.3390/diagnostics15091060 - 22 Apr 2025
Viewed by 228
Abstract
Background/Objectives: the aim of this study was to evaluate the safety and efficacy of percutaneous transhepatic lithotripsy using the SpyGlassDSTM cholangioscopy system for the treatment of difficult stones. Methods: Retrospectively, all patients treated with percutaneous transhepatic lithotripsy using SpyGlassDSTM cholangioscopy system [...] Read more.
Background/Objectives: the aim of this study was to evaluate the safety and efficacy of percutaneous transhepatic lithotripsy using the SpyGlassDSTM cholangioscopy system for the treatment of difficult stones. Methods: Retrospectively, all patients treated with percutaneous transhepatic lithotripsy using SpyGlassDSTM cholangioscopy system were analyzed. As primary outcome measures, the following data were assessed: the presence of a previous history of the hepatobiliary disease, location of stones, reasons for the choice of the procedure, previous balloon bilioplasty, type of pre-procedural imaging, procedural time, technical success, clinical success, and post-procedural complications (according to CIRSE classification). Clinical success was considered “primary” when achieved with a single treatment, and “secondary” if more than one treatment was required in the duration of follow-up. Results: 10 patients (6 males and 4 females, mean age = 64 years, SD = 22), all with cholangitis due to gallstones, underwent 11 PTL procedures using SpyGlassDSTM. Technical and clinical successes were achieved in all patients (100%). Primary success was observed in 4/10 (40%) patients, while the remaining 6/10 (60%) patients undergoing re-treatment, and all showed secondary success (100%). No periprocedural complications were observed. In 10/11 procedures (90%), no relevant adverse events were recorded within the first thirty days of follow-up. In 1/11 case (9%), mild complications (grade I according to CIRSE classification) were registered in the following days after the procedure (<30 days). Conclusions: in conclusion, the treatment of percutaneous transhepatic lithotripsy using SpyGlassDSTM cholangioscopy of difficult stones has been demonstrated as efficient and safe treatment. Full article
(This article belongs to the Special Issue Endoscopic Diagnostics for Pancreatobiliary Disorders 2025)
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10 pages, 648 KiB  
Article
Early Chronic Pancreatitis Findings by Endoscopic Ultrasonography (EUS) in Asymptomatic Patients with Pancreas Divisum
by Masatsugu Nagahama, Yuichi Takano, Fumitaka Niiya, Naoki Tamai, Jun Noda, Masataka Yamawaki and Tetushi Azami
Diagnostics 2025, 15(3), 253; https://doi.org/10.3390/diagnostics15030253 - 22 Jan 2025
Cited by 1 | Viewed by 708
Abstract
Background/Objectives: Pancreas divisum (PD) is a congenital malformation associated with chronic and recurrent acute pancreatitis. Although PD often presents asymptomatically, the extent to which early chronic pancreatitis (ECP) changes occur in asymptomatic patients with PD remains unclear. This study aimed to evaluate endoscopic [...] Read more.
Background/Objectives: Pancreas divisum (PD) is a congenital malformation associated with chronic and recurrent acute pancreatitis. Although PD often presents asymptomatically, the extent to which early chronic pancreatitis (ECP) changes occur in asymptomatic patients with PD remains unclear. This study aimed to evaluate endoscopic ultrasonography (EUS) findings indicative of ECP in asymptomatic patients with PD and investigate the relationship between these findings and background factors, such as age, sex, main pancreatic duct diameter, and alcohol intake. Methods: We retrospectively analyzed 17 asymptomatic patients diagnosed with PD at the Showa University Fujigaoka Hospital between January 2016 and May 2024. EUS was used to assess the pancreatic parenchyma and ductal features, and the findings were classified according to the Rosemont Classification (RC) and the Japan Pancreas Society (JPS) 2019 criteria for ECP (JDCECP2019). Statistical analyses were performed to examine the association between EUS findings and patient background factors. Results: EUS findings of ECP were observed in 8 of 17 asymptomatic patients with PD (47%) according to both the RC and the JDCECP2019 criteria. Hyperechoic foci without shadowing or strands were the most common findings, present in 82% of the patients. No significant associations were found between EUS findings and the background factors of age, sex, main pancreatic duct diameter, or alcohol intake. Conclusions: A considerable proportion of asymptomatic patients with PD exhibited EUS findings suggestive of early chronic pancreatitis. These findings indicate that early changes in chronic pancreatitis may be accompanied by asymptomatic PD. Full article
(This article belongs to the Special Issue Endoscopic Diagnostics for Pancreatobiliary Disorders 2025)
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