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Diagnostics
Special Issues
Hybrid PET/MR Imaging: Technological Advances and Multidisciplinary Clinical Applications
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Hybrid PET/MR Imaging: Technological Advances and Multidisciplinary Clinical Applications

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 79

Special Issue Editor

Dr. Marco Fogante

E-Mail Website
Guest Editor
Department of Radiological Sciences, Azienda Ospedaliero Universitaria Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy
Interests: cardiovascular radiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) imaging is increasingly recognized as a powerful tool in modern medical diagnostics, offering a unique combination of metabolic and molecular information from PET, with outstanding soft-tissue contrast and functional insights provided by MRI.

This Special Issue aims to collect and present high-quality research focused on the multidisciplinary applications of PET/MRI across a wide spectrum of clinical fields, including oncology, cardiology, neurology, senology, pediatrics, and musculoskeletal imaging. Particular attention will be given to studies that demonstrate how PET/MRI improves diagnostic accuracy, optimizes patient management, refines treatment planning, and enhances disease monitoring. Contributions exploring new radiotracers, imaging protocols, and the potential of PET/MRI to reduce radiation exposure are also encouraged. This Special Issue aims to foster cross-specialty dialog and promote the clinical integration of PET/MRI as a non-invasive, multiparametric, and patient-centered imaging modality.

We welcome original research articles, reviews, clinical case reports, and technical notes that focus on innovations, diagnostic performance, clinical workflow integration, and novel tracer developments within PET/MR imaging.

Dr. Marco Fogante
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PET/MR
  • hybrid imaging
  • molecular imaging
  • diagnostic imaging
  • oncology
  • cardiology
  • neurology
  • senology
  • pediatrics
  • musculoskeletal imaging
  • precision medicine
  • clinical applications

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Published Papers (1 paper)

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20 pages, 7661 KiB  
Systematic Review
Hybrid PET/MRI in Inflammatory Cardiac Diseases: A Systematic Review and Single-Center Experience
by Marco Fogante, Giulia Argalia, Paolo Esposto Pirani, Cinzia Romagnolo, Liliana Balardi, Giulio Argalia, Fabio Massimo Fringuelli and Nicolò Schicchi
Diagnostics 2025, 15(13), 1670; https://doi.org/10.3390/diagnostics15131670 - 30 Jun 2025
Abstract
Background/Objectives: Hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) is an emerging imaging modality that combines metabolic and anatomical data in a single session, offering promising diagnostic performance in various cardiac conditions. However, its role in inflammatory cardiac diseases (ICDs), such as myopericarditis and [...] Read more.
Background/Objectives: Hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) is an emerging imaging modality that combines metabolic and anatomical data in a single session, offering promising diagnostic performance in various cardiac conditions. However, its role in inflammatory cardiac diseases (ICDs), such as myopericarditis and endocarditis, remains underexplored. This study aims to evaluate the diagnostic value of PET/MRI in ICDs through a systematic review of the literature, complemented by our institutional experience. Methods: We conducted a systematic review of PubMed, Scopus, and Embase up to April 2025, using keywords including “PET/MRI,” “PET/MR”, “myocarditis”, “endocarditis”, “pericarditis”, “inflammatory heart disease”, and “inflammatory cardiac disease”. Studies reporting the use of hybrid PET/MRI in ICDs were included and analyzed. Additionally, we retrospectively reviewed clinical and imaging data from 33 consecutive patients who underwent PET/MRI in our center for suspected myopericarditis or endocarditis between September 2022 and March 2025. Results: The systematic review identified 12 eligible studies evaluating PET/MRI in ICDs, highlighting its added value in cases with inconclusive findings on standalone MRI or PET. Common advantages reported included improved localization of active inflammation, better characterization of tissue damage, and enhanced diagnostic confidence. In our cohort, hybrid PET/MRI was considered diagnostically useful in 16/21 (76%) of myopericarditis cases and 9/12 (75%) of endocarditis cases, particularly for reclassifying uncertain findings and guiding clinical management. Conclusions: The combined analysis of the current literature and real-world clinical experience supports the diagnostic utility of hybrid PET/MRI in the evaluation of ICDs. This multimodal approach improves the interpretation of equivocal cases, facilitates accurate diagnosis, and may influence therapeutic decisions. However, larger prospective studies are needed to confirm these findings and establish standardized protocols. Full article
(This article belongs to the Special Issue Hybrid PET/MR Imaging: Technological Advances and Multidisciplinary Clinical Applications)
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