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Diagnostics
Special Issues
Clinical Applications of CT and MRI
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Clinical Applications of CT and MRI

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 585

Special Issue Editor

Dr. Francis Zarb

E-Mail Website
Guest Editor
Department of Radiography, University of Malta, Msida, Malta
Interests: medical imaging

Special Issue Information

Dear Colleagues,

The aim of this Special Issue of Diagnostics is to explore recent advancements and clinical applications of computed tomography (CT) and magnetic resonance imaging (MRI) in imaging practice.

This collection of works will encompass a wide range of topics, including the latest technological innovations and the role of CT and MRI in diagnosing, monitoring, and treating various conditions, from oncology to neurology.

We invite submissions of original research articles, review papers, and case studies that highlight clinical outcomes, best practices, and the efficacy of these imaging modalities in patient management. Additionally, we encourage contributions that discuss future directions and emerging trends in CT and MRI applications, addressing both challenges and opportunities in the field.

With this Special Issue, we aim to provide a comprehensive resource for clinicians and researchers, enhancing the understanding and implementation of these critical imaging techniques in patient care.

Dr. Francis Zarb
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • CT
  • MRI
  • diagnosis
  • prognosis
  • oncology
  • neurology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

13 pages, 497 KiB  
Article
The Diagnostic Accuracy of an Abbreviated vs. a Full MRI Breast Protocol in Detecting Breast Lobular Carcinoma: A Single-Center ROC Study
by Francis Zarb, Deborah Mizzi, Paul Bezzina and Leanne Galea
Diagnostics 2025, 15(12), 1497; https://doi.org/10.3390/diagnostics15121497 - 12 Jun 2025
Viewed by 400
Abstract
Background/Objectives: Abbreviated breast MRI protocols have been proposed as a faster and more cost-effective alternative to standard full protocols for breast cancer detection. This study aimed to compare the diagnostic accuracy of an abbreviated protocol with that of a full protocol in identifying [...] Read more.
Background/Objectives: Abbreviated breast MRI protocols have been proposed as a faster and more cost-effective alternative to standard full protocols for breast cancer detection. This study aimed to compare the diagnostic accuracy of an abbreviated protocol with that of a full protocol in identifying lobular breast carcinoma using Breast Imaging Reporting and Data System (BI-RADS) classification. The diagnostic performance was evaluated against a gold standard comprising biopsy-proven lobular carcinoma or negative follow-up imaging, using Receiver Operating Characteristic (ROC) analysis and performance metrics such as sensitivity and specificity. Methods: A retrospective analysis was conducted on 35 breast MRI examinations performed between January 2019 and December 2021. Of these, 20 cases had biopsy-confirmed lobular carcinoma, and 15 were determined to be normal based on at least 12 months of negative follow-up imaging. Two radiologists independently reviewed the images using only the abbreviated protocol, blinded to the original reports. Their findings were then compared with the initial full-protocol MRI reports. BI-RADS categories 1 and 2 were considered negative for malignancy, while BI-RADS categories 3, 4, and 5 were considered positive. Results: The area under the ROC curve (AUC) was 1.0 for the full protocol and 0.920 and 0.922 for Radiologists A and B, respectively, using the abbreviated protocol. All malignant lesions were correctly identified by both radiologists across both protocols, resulting in a sensitivity of 100%. However, the abbreviated protocol demonstrated significantly lower specificity (73.3% for Radiologist A and 53.5% for Radiologist B) compared to 100% specificity with the full protocol (p < 0.05). Lymph node involvement was correctly identified in 6–7 of 7 cases, though Radiologist A reported four false positives. Lesion laterality and count matched histopathology in 75–90% of cancer cases depending on protocol. Lesion localization was accurate in 60–80% of cases using the abbreviated protocol, though size comparisons were limited due to the incomplete radiological documentation of dimensions. Conclusions: While the abbreviated MRI protocol achieved diagnostic accuracy and sensitivity comparably to the full protocol, it demonstrated reduced specificity. These findings suggest that abbreviated MRI breast protocol may be a viable screening tool, although the higher false-positive rate should be considered in clinical decision-making. Full article
(This article belongs to the Special Issue Clinical Applications of CT and MRI)
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