Advancements in the Diagnosis and Management of Liver Disease and Liver Transplantation

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 507

Special Issue Editor


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Guest Editor
Radiology, Medical Imaging and Interventional Radiology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
Interests: multiparametric MRI (MPMRI); multidetector CT (MDCT); focal and diffuse liver pathology; liver transplantation; specific liver contrast material; advanced imaging techniques
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Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to present the multiparametric imaging used to evaluate focal and diffuse liver pathology, as well as the transplanted liver with an emphasis on advanced imaging techniques (such as spectral computed tomography, CT perfusion of the liver, functional MRI, MR elastography, and mapping T1 and T2), hepatocytic specific contrast material, and imaging biomarkers. Further, this Special Issue will highlight the key points used for rapid and correct imaging diagnostics, the role of interventional radiology in liver tumor treatment and liver transplant complications, and the role of a multidisciplinary team in the management of patients with liver disease or with liver transplantation.

Prof. Dr. Ioana Gabriela Lupescu
Guest Editor

Manuscript Submission Information

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Keywords

  • focal and diffuse liver pathology
  • liver transplantation
  • MPMRI
  • MDCT
  • advanced imaging techniques
  • specific liver contrast material
  • imaging biomarkers
  • interventional radiology

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Published Papers (1 paper)

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Review

20 pages, 305 KiB  
Review
Liver Elastography Methods for Diagnosis of De Novo and Recurrent Hepatocellular Carcinoma
by Razvan Cerban, Speranta Iacob, Carmen Ester, Mihaela Ghioca, Mirela Chitul, Razvan Iacob and Liana Gheorghe
Diagnostics 2025, 15(9), 1087; https://doi.org/10.3390/diagnostics15091087 - 25 Apr 2025
Viewed by 320
Abstract
Hepatocellular carcinoma (HCC), a common consequence of chronic liver disease, ranks among the most prevalent cancers globally and contributes significantly to cancer-related mortality. Liver fibrosis is intimately associated with hepatic function and the likelihood of future HCC occurrence. Despite the fact that liver [...] Read more.
Hepatocellular carcinoma (HCC), a common consequence of chronic liver disease, ranks among the most prevalent cancers globally and contributes significantly to cancer-related mortality. Liver fibrosis is intimately associated with hepatic function and the likelihood of future HCC occurrence. Despite the fact that liver biopsy continues to be the gold standard for diagnosing fibrosis, its utility is hindered by cost and invasiveness, along with patient unease, procedural rejection, and potential adverse effects. Liver elastography has become a leading noninvasive means of assessing tissue stiffness with considerable diagnostic precision. Malignant tumors generally exhibit higher cellularity in comparison to benign ones, resulting in increased stiffness. Elastography techniques capitalize on alterations in tissue elasticity stemming from specific pathological or physiological processes. Technological innovations, such as advanced ultrasound imaging and artificial intelligence (AI)-integrated systems, are paving the way for enhanced diagnostic accuracy and risk prediction. Recent research underscores the potential of elastography in managing HCC patients, presenting novel clinical applications, including prediction of HCC development, differentiation between malignant and benign liver lesions, evaluating treatment response, and forecasting recurrence post-treatment, though certain findings remain contentious. Therefore, this review aims to sum up the latest advancements in liver elastography for HCC patients, outlining its applications while addressing existing limitations and avenues for future progress. Full article
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