Gynecological Oncology: Advanced Diagnosis and Management in 2025

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1331

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
Interests: clinical oncology; gynecological oncology; gyneco-oncology surgery; HPV
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Co-Guest Editor
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
Interests: immunology of heathy and pathologic pregnancy; immunology of gynecologic malignancies; operative gynecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gynecological oncology is rapidly evolving, with a growing demand for advancements in diagnosis and management strategies. The need for early detection, improved treatment options, and a better understanding of the underlying mechanisms of gynecological cancers has never been more important. This Special Issue aims to bring together leading experts, researchers, and clinicians from around the world to share their insights, innovations, and research findings related to gynecological oncology. We welcome manuscripts on the etiology, diagnosis, and treatment of female cancers from early to advanced stages, as well as research from any discipline related to this area of ​​interest.

To ensure the highest quality of contributions, we assembled a distinguished panel of experts to serve as Guest Editors for this Special Issue. We believe that the publication of this Special Issue in Diagnostics will serve as a valuable resource for clinicians, researchers, and healthcare professionals involved in the care and management of gynecological oncology patients. It will also contribute to the overall advancement of our understanding of these complex diseases.

Topics of interest for this Special Issue include (but are not limited to) the following:

  • New trends in gynecologic oncology research;
  • Novel diagnostic techniques and biomarkers in gynecological cancers;
  • Advances in surgical interventions and minimally invasive procedures;
  • Personalized treatment approaches for gynecological malignancies;
  • Multidisciplinary care and collaborative management strategies;
  • Novelties in histopathological processing;
  • Radiological staging of gynecologic cancer;
  • Surgical staging of gynecologic cancer;
  • Pre- and postoperative care;
  • Standardization of surgical methods;
  • Sentinel lymph node mapping;
  • Role of image-guided radiation therapy;
  • Neoadjuvant and adjuvant chemotherapy;
  • Palliative care and quality-of-life considerations;
  • Artificial intelligence, machine learning, emerging digital technologies, and their impact in gynecological oncology.

Dr. Zoard T. Krasznai
Dr. Rudolf Lampé
Guest Editors

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Keywords

  • gynecology
  • oncology
  • endometrial cancer
  • ovarian cancer
  • cervical cancer
  • diagnosis
  • staging
  • surgical methods
  • standardization of surgery
  • treatment
  • innovation
  • precision medicine
  • artificial intelligence
  • machine learning

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Published Papers (1 paper)

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18 pages, 1554 KiB  
Systematic Review
Surgical Outcomes in Laparoscopic Hysterectomy, Robotic-Assisted, and Laparoscopic-Assisted Vaginal Hysterectomy for Uterine and Cervical Cancers: A Systematic Review
by Jabri Tabrizi Madalina Ioana, Florica Voiță-Mekereș, Alexandru Catalin Motofelea, Duta Ciprian, Lazăr Fulger, Isaic Alexandru, Cristi Tarta, Pantea Stelian, Elena Silvia Bernad and Hoinoiu Teodora
Diagnostics 2024, 14(24), 2782; https://doi.org/10.3390/diagnostics14242782 - 11 Dec 2024
Cited by 1 | Viewed by 1066
Abstract
Background/Objectives: This systematic review aimed to evaluate the outcomes of minimally invasive techniques in gynecological cancer surgery, specifically laparoscopic hysterectomies (LHs), robotic-assisted hysterectomies (RHs), and laparoscopic-assisted vaginal hysterectomies (LAVHs). Methods: We conducted a comprehensive search of electronic databases including PubMed and MedLine from [...] Read more.
Background/Objectives: This systematic review aimed to evaluate the outcomes of minimally invasive techniques in gynecological cancer surgery, specifically laparoscopic hysterectomies (LHs), robotic-assisted hysterectomies (RHs), and laparoscopic-assisted vaginal hysterectomies (LAVHs). Methods: We conducted a comprehensive search of electronic databases including PubMed and MedLine from January 2010 to August 2024. The search included randomized controlled trials (RCTs) and observational studies. Studies were selected based on inclusion criteria such as a focus on LHs, RHs, or LAVHs, and reporting on key outcomes like recovery rates, overall survival (OS) rates, disease-free survival (DFS), postoperative complications, and surgery time. Exclusion criteria were applied to omit non-randomized studies, non-English publications, and those lacking relevant data. Results: The analysis included 35 studies on gynecological cancers and surgical procedures, conducted across multiple countries. Among them, 8 were RCTs from countries like the Netherlands and Italy, while 20 were retrospective cohort studies from China and the USA. The studies varied in design, cancer type, and participant age, highlighting diverse surgical approaches and the adaptation of minimally invasive techniques in gynecological cancer treatment. LH and RH demonstrated similar oncological safety with comparable OS and DFS rates. RH was associated with reduced blood loss, but longer operative times compared to LH. LAVH showed favorable perioperative outcomes, including shorter hospital stays and faster recovery, but was less frequently studied in advanced-stage cancers. Complication rates were generally lower in minimally invasive surgeries compared to open procedures. The findings support the efficacy of LH and RH as viable alternatives to open surgery, with specific advantages depending on patient and disease characteristics. Conclusions: Minimally invasive techniques in gynecological cancer surgery offer significant advantages in terms of recovery and complication rates. Despite these benefits, further research is needed to confirm their oncological safety and overall effectiveness compared to traditional open surgeries. Full article
(This article belongs to the Special Issue Gynecological Oncology: Advanced Diagnosis and Management in 2025)
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