Alzheimer's Disease: Diagnosis, Pathology and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1061

Special Issue Editor


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Guest Editor
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA
Interests: neurodegenerative disorders; molecular diagnostics; neuropathology
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Special Issue Information

Dear Colleagues,

Alzheimer's disease (AD) is one of the most significant public health challenges of our time, affecting millions of people and their families worldwide. As the global population ages, the incidence of AD continues to rise, highlighting the urgent need for understanding its complex pathology, early diagnosis, and effective management strategies.

This special issue aims to provide researchers, clinicians, and readers with a comprehensive platform to explore in depth the molecular and cellular mechanisms that lead to AD, advances in diagnostic techniques, and innovative treatments.

Dr. Liam L. Chen
Guest Editor

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Keywords

  • Alzheimer's disease
  • neuropathology
  • PET
  • MRI
  • CT
  • dementia
  • neurodegeneration
  • immunotherapy
  • treatment strategy
  • disease management

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Published Papers (1 paper)

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Research

11 pages, 1546 KiB  
Article
Volume Changes in Brain Subfields of Patients with Alzheimer’s Disease After Transcranial Ultrasound Stimulation
by Sheng-Yao Huang, Meng-Ting Wu, Chung-Fu Sun and Feng-Yi Yang
Diagnostics 2025, 15(3), 359; https://doi.org/10.3390/diagnostics15030359 - 4 Feb 2025
Viewed by 817
Abstract
Background/Objectives: Alzheimer’s disease (AD) is characterized by progressive brain atrophy marked by cognitive decline and memory loss, which significantly affect patients’ quality of life. Transcranial ultrasound stimulation (TUS) is a potential physical treatment for AD patients. However, the specific brain regions stimulated [...] Read more.
Background/Objectives: Alzheimer’s disease (AD) is characterized by progressive brain atrophy marked by cognitive decline and memory loss, which significantly affect patients’ quality of life. Transcranial ultrasound stimulation (TUS) is a potential physical treatment for AD patients. However, the specific brain regions stimulated by TUS and its therapeutic effects remain unclear. Methods: In this study, magnetic resonance imaging (MRI) and FreeSurfer segmentation were employed to assess alterations in the brain volume of AD patients after TUS. Results: Our findings revealed significant volume increases in the corpus callosum (CC) and lateral orbitofrontal cortex (lOFC) in the TUS group. Moreover, the volumetric changes in the CC were strongly correlated with improvements in the Mini-Mental State Examination score, which is a widely used measure of cognitive function of AD patients. Conclusions: TUS has the potential to alleviate disease progression and offers a non-invasive therapeutic approach to the improvement of cognitive function in AD patients. Full article
(This article belongs to the Special Issue Alzheimer's Disease: Diagnosis, Pathology and Management)
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