Advanced Imaging of Acute Ischemic Stroke and Chronic Cerebral Hypoperfusion
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 7
Special Issue Editors
2. Clinical Neuroscience Center, University Hospital Zurich, 8091 Zurich, Switzerland
Interests: neurosurgery; endoscopic neurosurgery; neuro-oncology
Interests: cerebrovascular reactivity; cerebral blood flow; fMRI; brain tumor; cerebrovascular disease
Special Issues, Collections and Topics in MDPI journals
2. Clinical Neuroscience Center, University Hospital Zurich, 8091 Zurich, Switzerland
Interests: hemodynamic; cerebral glioma; glioblastoma; perfusion computed tomography; MRI; perfusion MRI; cerebrovascular reactivity
Special Issue Information
Dear Colleagues,
Neuroimaging has become indispensable in the diagnosis and management of strokes, providing crucial insights into the pathophysiology of both acute ischemia and chronic manifestations.
In acute ischemic stroke, imaging is essential for the timely diagnosis, identification of stroke etiology, and appropriate patient selection for therapies such as intravenous thrombolysis or endovascular treatment (EVT). Modern imaging techniques allow for the rapid assessment of vessel patency and tissue viability. However, challenges remain in the standardization of imaging protocols across centers. Future developments may include more precise viability markers and AI-assisted interpretation to support individualized treatment decisions.
A rapidly evolving area of interest is the use of advanced imaging to assess cerebral tissue hemodynamics following EVTs for large-vessel occlusion. Despite successful recanalization, up to half of patients fail to show significant neurological improvements—a phenomenon known as reperfusion failure. Advanced imaging techniques are being explored to characterize microvascular dysfunction and tissue vulnerability in this setting. Yet, reliable markers of microcirculatory failure remain elusive, and further clinical validation is required.
In the chronic phase, patients with high-grade large-artery stenosis or occlusion may experience sustained cerebral hypoperfusion without overt infarction. This condition has been associated with cortical thinning and vascular cognitive impairment, even in the absence of apparent ischemic symptoms. Emerging imaging approaches offer promising tools to investigate these subtle but clinically relevant changes. However, current techniques remain limited in sensitivity and accessibility, highlighting the need for improved diagnostic methods to detect early tissue compromise and to elucidate the clinical implications of chronic hypoperfusion.
This Special Issue aims to explore the expanding role of advanced neuroimaging techniques in the understanding, diagnosis, and management of ischemic brain disease across its spectrum—from acute manifestation to chronic dysfunction.
Dr. Vittorio Stumpo
Dr. Jorn Fierstra
Dr. Jacopo Bellomo
Guest Editors
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Keywords
- acute ischemic stroke
- chronic cerebral hypoperfusion
- neuroimaging
- reperfusion failure
- vascular cognitive impairment
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