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Diagnostics
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Diagnosis of Hepatobiliary and Pancreatic Diseases
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Diagnosis of Hepatobiliary and Pancreatic Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 4913

Special Issue Editor

Prof. Dr. Dong Woo Shin

E-Mail Website
Guest Editor
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22, Gwanpyeong-ro 170 Beon-gil, Dongan-gu, Anyang 14068, Gyeonggi-do, Republic of Korea
Interests: gastric cancer; gastrointestinal disease

Special Issue Information

Dear Colleagues,

The special issue "Diagnosis of Hepatobiliary and Pancreatic Diseases" aims to provide an in-depth exploration of the latest advancements, research findings, and diagnostic approaches in the field of hepatobiliary and pancreatic diseases. These diseases encompass a wide range of conditions affecting the liver, bile ducts, gallbladder, and pancreas, presenting significant challenges in diagnosis and management. This special issue will focus on various diagnostic modalities, including imaging techniques, molecular diagnostics, and biomarkers, to improve the accuracy and timeliness of diagnosis.

This issue will cover topics such as the role of advanced imaging modalities like computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) in the diagnosis and staging of hepatobiliary and pancreatic diseases. Additionally, it will explore the utility of molecular diagnostics, including genetic and genomic approaches, in identifying disease-causing variants and predicting treatment response. The special issue will also emphasize the emerging field of biomarkers and their potential use in early detection, prognosis, and monitoring of disease progression. 

By compiling research articles, reviews, and case studies, this special issue will serve as a comprehensive resource for clinicians, researchers, and healthcare professionals involved in the diagnosis and management of hepatobiliary and pancreatic diseases. It aims to facilitate knowledge exchange, foster innovation in diagnostic approaches, and improve patient outcomes through early and accurate diagnosis. The special issue is expected to contribute to the advancement of diagnostic strategies and personalized care in hepatobiliary and pancreatic diseases.

Prof. Dr. Dong Woo Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatobiliary and pancreatic diseases
  • imaging techniques
  • molecular diagnostics
  • biomarkers

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Published Papers (6 papers)

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20 pages, 1801 KiB  
Article
Predictive Value of Several Parameters for Severity of Acute Pancreatitis in a Cohort of 172 Patients
by Florina Alexandra Liță (Cofaru), Irina Anca Eremia, Silvia Nica, Lăcrămioara Aurelia Brîndușe, Narcis-Octavian Zărnescu, Alexandru Constantin Moldoveanu, Loredana Gabriela Goran and Carmen Fierbințeanu-Braticevici
Diagnostics 2025, 15(4), 435; https://doi.org/10.3390/diagnostics15040435 - 11 Feb 2025
Viewed by 803
Abstract
Background: The optimal management of patients with acute pancreatitis is directly related to the early detection of the mild, moderate, or severe forms of the disease, which remains a continuous challenge despite the availability of various severity scores. The aim of this [...] Read more.
Background: The optimal management of patients with acute pancreatitis is directly related to the early detection of the mild, moderate, or severe forms of the disease, which remains a continuous challenge despite the availability of various severity scores. The aim of this study was to identify prognostic factors with the highest predictive value specific to the local patients and elaborate the score to identify the severe cases. Materials and Methods: A retrospective observational cohort study included 172 patients diagnosed with acute pancreatitis. Personal, clinical, laboratory, and imaging factors and their influence on the severity of acute pancreatitis were evaluated. Results: Etiology nonA-nonB (any etiology except unique alcoholic or biliary etiology), presence of diabetes mellitus, the pain Visual Analogue Scale (VAS), White Blood Cells (WBCs), and CRP (C-reactive protein) levels were found to be directly associated with the severity of acute pancreatitis (AP). Prediction scores were calculated to estimate disease severity using the following regression equations: Prediction Acute Pancreatitis Severity (PAPS) score I = 1.237 + 0.144 × nonA-nonB (0 = no, 1 = yes) + 0.001 × WBC1 + 0.027 × VAS0 and PAPS score II = 1.189 + 0.001 × CRP (mg/L) + 0.135 × nonA-nonB etiology (0 = no, 1 = yes) + 0.025 × VAS0 − 0.047 × CA1. The PAPS Score II demonstrated the best performance. At a cut-off value of 1.248, the score had 80% sensitivity, 80.9% specificity, a positive predictive value (PPV) of 28.6%, a negative predictive value (NPV) of 97.7%, and an accuracy of 80.8%. For a cut-off value of 221.5 mg/L, the accuracy of CRP was 81.4% for predicting severe AP. Conclusions: The PAPS score II is an easy-to-use, fast, and affordable score for determining cases of severe disease for patients diagnosed with AP. Full article
(This article belongs to the Special Issue Diagnosis of Hepatobiliary and Pancreatic Diseases)
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14 pages, 1167 KiB  
Article
Possible Use of Body Surface Area Value for Estimating Skeletal Muscle Mass in Chronic Liver Disease
by Kazunori Yoh, Takashi Nishimura, Naoto Ikeda, Tomoyuki Takashima, Nobuhiro Aizawa, Yukihisa Yuri, Taro Kimura, Kohei Yoshihara, Ryota Yoshioka, Shoki Kawata, Yuta Kawase, Ryota Nakano, Hideyuki Shiomi, Shinya Fukunishi, Shinichiro Shinzaki, Shuhei Nishiguchi and Hirayuki Enomoto
Diagnostics 2025, 15(3), 263; https://doi.org/10.3390/diagnostics15030263 - 23 Jan 2025
Viewed by 600
Abstract
Background/Objectives: Sarcopenia is an important clinical feature of patients with chronic liver disease (CLD). However, special devices are required to determine skeletal muscle mass. We evaluated the usefulness of body surface area (BSA) for estimating muscle mass and diagnosing sarcopenia in patients with [...] Read more.
Background/Objectives: Sarcopenia is an important clinical feature of patients with chronic liver disease (CLD). However, special devices are required to determine skeletal muscle mass. We evaluated the usefulness of body surface area (BSA) for estimating muscle mass and diagnosing sarcopenia in patients with CLD. Methods: We retrospectively studied 1889 Japanese patients with CLD who underwent bioimpedance analysis (BIA) (training cohort, n = 983; validation cohort, n = 906). The optimal cutoff values for predicting low skeletal muscle mass index (SMI) were determined using ROC analysis. We also assessed 1229 patients whose BSA and grip strength (GS) data were obtained on the same day and evaluated the diagnostic performance of the determined cutoff values of BSA for the diagnosis of sarcopenia. Results: In the training cohort, a strong correlation was observed between the SMI and BSA (r = 0.883, p < 0.0001). The cutoff values of BSA for predicting low SMI were 1.68 m2 for men and 1.48 m2 for women. Regarding the presence of low SMI, 776 (78.9%) and 730 (80.5%) patients were correctly diagnosed in the training and validation cohorts, respectively. The sensitivity and specificity of the combination of BSA and GS for sarcopenia were 82.7% and 97.1%, respectively, and 1175 patients (95.6%) were correctly diagnosed. Conclusions: BSA was highly correlated with SMI, suggesting that BSA could facilitate noninvasive estimation of low skeletal muscle mass in patients with CLD. Full article
(This article belongs to the Special Issue Diagnosis of Hepatobiliary and Pancreatic Diseases)
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10 pages, 797 KiB  
Article
Predictive Models for Non-Alcoholic Fatty Liver Disease Diagnosis in Mexican Patients with Gallstone Disease: Sex-Specific Insights
by Nemry Rodríguez-Hernández, María-Luisa Lazo-de-la-Vega-Monroy, Yeniley Ruiz-Noa, Monica-del-Carmen Preciado-Puga, Juana-Rosalba Garcia-Ramirez, Benjamin Jordan-Perez, Serafin Garnelo-Cabañas and Lorena-del-Rocío Ibarra-Reynoso
Diagnostics 2024, 14(14), 1487; https://doi.org/10.3390/diagnostics14141487 - 11 Jul 2024
Viewed by 1043
Abstract
(1) Background: Evidence regarding Non-Alcoholic Fatty Liver Disease (NAFLD) diagnosis is limited in the context of patients with gallstone disease (GD). This study aimed to assess the predictive potential of conventional clinical and biochemical variables as combined models for diagnosing NAFLD in patients [...] Read more.
(1) Background: Evidence regarding Non-Alcoholic Fatty Liver Disease (NAFLD) diagnosis is limited in the context of patients with gallstone disease (GD). This study aimed to assess the predictive potential of conventional clinical and biochemical variables as combined models for diagnosing NAFLD in patients with GD. (2) Methods: A cross-sectional study including 239 patients with GD and NAFLD diagnosed by ultrasonography who underwent laparoscopic cholecystectomy and liver biopsy was conducted. Previous clinical indices were also determined. Predictive models for the presence of NAFLD stratified by biological sex were obtained through binary logistic regression and sensitivity analyses were performed. (3) Results: For women, the model included total cholesterol (TC), age and alanine aminotransferase (ALT) and showed an area under receiver operating characteristic curve (AUC) of 0.727 (p < 0.001), sensitivity of 0.831 and a specificity of 0.517. For men, the model included TC, body mass index (BMI) and aspartate aminotransferase (AST), had an AUC of 0.898 (p < 0.001), sensitivity of 0.917 and specificity of 0.818. In both sexes, the diagnostic performance of the designed equations was superior to the previous indices. (4) Conclusions: These models have the potential to offer valuable guidance to healthcare providers in clinical decision-making, enabling them to achieve optimal outcomes for each patient. Full article
(This article belongs to the Special Issue Diagnosis of Hepatobiliary and Pancreatic Diseases)
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14 pages, 1313 KiB  
Case Report
Various Phenotypes of Ectopic Pancreatic Tissue in Children: Case Series and Literature Review
by Elena Roxana Matran, Andra-Mihaela Diaconu, Oana Neagu and Alexandru-Ioan Ulmeanu
Diagnostics 2025, 15(10), 1193; https://doi.org/10.3390/diagnostics15101193 - 8 May 2025
Viewed by 169
Abstract
Background/Objectives: Ectopic pancreatic tissue (EPT), an infrequently documented condition within the pediatric population, is often asymptomatic. When clinical manifestations do occur, their severity is contingent upon the location, size, and involvement of the adjacent mucosa. Methods: This is a case series [...] Read more.
Background/Objectives: Ectopic pancreatic tissue (EPT), an infrequently documented condition within the pediatric population, is often asymptomatic. When clinical manifestations do occur, their severity is contingent upon the location, size, and involvement of the adjacent mucosa. Methods: This is a case series study, involving children aged 15 days–13 years diagnosed with EPT from a single institution. Results: Six cases of EPT were identified. Five of the six cases presented with both EPT and ectopic gastric tissue, located at the site of Meckel’s diverticulum, while one case presented EPT exclusively, which was localized in the duodenum I. A case of Littre’s hernia was identified in a newborn. Two of the six cases experienced gastrointestinal bleeding. Conclusions: The identification of EPT continues to pose a diagnostic challenge, as the symptoms are nonspecific and can sometimes be life-threatening. Additionally, there are currently no specific paraclinical investigations available for this purpose. Full article
(This article belongs to the Special Issue Diagnosis of Hepatobiliary and Pancreatic Diseases)
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6 pages, 1566 KiB  
Interesting Images
Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst—A Rare Double Diagnosis
by Minhye Kim, Jungwook Yang, Daehyun Song, Hyojung An and Dongchul Kim
Diagnostics 2024, 14(23), 2727; https://doi.org/10.3390/diagnostics14232727 - 4 Dec 2024
Viewed by 617
Abstract
Gastric duplication cysts (GDCs) are rare congenital anomalies, often identified during infancy or childhood. Although typically benign, there have been sporadic reports of malignant transformations, including adenocarcinoma and rare mixed tumors. Herein, we describe a rare case of mixed pancreatobiliary ductal adenocarcinoma and [...] Read more.
Gastric duplication cysts (GDCs) are rare congenital anomalies, often identified during infancy or childhood. Although typically benign, there have been sporadic reports of malignant transformations, including adenocarcinoma and rare mixed tumors. Herein, we describe a rare case of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma occurring within a GDC in a 54-year-old Korean woman with a history of melena and hematemesis. Initial gastroscopy and positron emission tomography–computed tomography (PET-CT) revealed a protruding stomach mass. A laparoscopic total gastrectomy was performed, and histological examination confirmed a mixed carcinoma originating from an ectopic pancreas within the duplication cyst. This case is unique as it is the first reported instance in the world of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma arising from an ectopic pancreas within a GDC. This highlights the importance of considering pancreatobiliary-type adenocarcinoma in the differential diagnosis of malignancies originating from GDCs, which has implications for treatment strategies. Full article
(This article belongs to the Special Issue Diagnosis of Hepatobiliary and Pancreatic Diseases)
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3 pages, 401 KiB  
Interesting Images
Cholecystocutaneous Fistula
by Francisco Tustumi, Giane Prata da Costa Filha and Guilherme Carvalhal Gnipper Cirillo
Diagnostics 2024, 14(13), 1386; https://doi.org/10.3390/diagnostics14131386 - 29 Jun 2024
Viewed by 1096
Abstract
This image article presents an 88-year-old indigenous woman with a history of several episodes of abdominal pain, for which she went to numerous different hospitals in the countryside, was always treated with analgesics, and then discharged. After a long time, the patient eventually [...] Read more.
This image article presents an 88-year-old indigenous woman with a history of several episodes of abdominal pain, for which she went to numerous different hospitals in the countryside, was always treated with analgesics, and then discharged. After a long time, the patient eventually was evaluated with magnetic resonance imaging. The test revealed a displaced gallbladder with thickened walls, multiple stones, and a fistulous tract extending to the skin. This case underscores the significant challenges faced by patients in regions with limited healthcare access, highlighting the impact of delayed diagnosis and inadequate management on patient outcomes. Full article
(This article belongs to the Special Issue Diagnosis of Hepatobiliary and Pancreatic Diseases)
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