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Diagnostics
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Advances in Sarcopenia: Predictive Biomarkers, Clinical Characteristics, and Therapeutic Strategies
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Advances in Sarcopenia: Predictive Biomarkers, Clinical Characteristics, and Therapeutic Strategies

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 3041

Special Issue Editor

Dr. Jong Geol Do

E-Mail Website
Guest Editor
Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
Interests: musculoskeletal diseases; electrodiagnostic medicine; spinal cord injury; intensive care unit rehabilitation; respiratory rehabilitation; sarcopenia

Special Issue Information

Dear Colleagues,

This Special Issue seeks to explore the advancements in the understanding, diagnosis, and treatment of sarcopenia, focusing on the integration of predictive biomarkers, clinical characteristics, and innovative therapeutic strategies. By compiling research on biochemical and physiological biomarkers, this Special Issue aims to determine the pathways through which the biomarkers of sarcopenia can be predicted and monitored more effectively. In addition to traditional clinical observations, we encourage submissions that utilize advanced imaging techniques, biometric analyses, and computational modeling to refine the clinical profiles associated with sarcopenia.

We also aim to highlight therapeutic advances, ranging from pharmacological interventions to non-invasive therapies that employ digital health technologies. The scope of this Special Issue extends to interdisciplinary approaches that combine nutrition and rehabilitation to offer comprehensive treatment. Through a collaborative exploration of these themes, this Special Issue will provide a platform for researchers to share insights and propose innovative solutions that address the global challenge of sarcopenia in aging populations. This Special Issue will serve as a crucial resource for clinicians and researchers involved in the management of sarcopenia.

Dr. Jong Geol Do
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sarcopenia
  • predictive biomarkers
  • digital health technologies
  • interdisciplinary treatment approaches
  • aging population management

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

8 pages, 217 KiB  
Article
The Development of a Quantitative Disability Assessment Tool in Patients with Idiopathic Parkinson’s Disease
by Han Gil Seo, Seo Jung Yun, Yoojin Song, Ho Seok Lee, Dae Hyun Kim and Won Hyuk Chang
Diagnostics 2024, 14(18), 2063; https://doi.org/10.3390/diagnostics14182063 - 18 Sep 2024
Viewed by 788
Abstract
Background/Objectives: The objective of this study was to develop a novel quantitative disability assessment tool for patients with idiopathic Parkinson’s disease (IPD). Methods: A total of 47 patients with IPD were recruited from two hospitals. A specialist in Rehabilitation Medicine utilized the modified [...] Read more.
Background/Objectives: The objective of this study was to develop a novel quantitative disability assessment tool for patients with idiopathic Parkinson’s disease (IPD). Methods: A total of 47 patients with IPD were recruited from two hospitals. A specialist in Rehabilitation Medicine utilized the modified Schwab and England Activities of Daily Living Scale (mSEADL) as a reference, conducting a comprehensive medical chart review and an in-depth interview. The novel-developed disability measurement was calculated as ((mSEADL during the on-state) × (time of on-state)) + ((mSEADL during the off-state) × (time of off-state))/(waking time). Additionally, the degree of disability was assessed using the Korean version of the Modified Barthel Index during the on-state. Results: Twenty-four participants (51.1%) exhibited the off-state during waking hours. In patients exhibiting an off-state, the mSEADL score was significantly lower during the off-state than during the on-state (p < 0.05). The novel-developed disability measurement demonstrated a higher correlation coefficient with the reference mSEADL (0.960) than with the K-MBI (0.808), with statistical significance (p < 0.05). Conclusions: The results demonstrated that larger IPD patients exhibited an on–off phenomenon with greater dependency during the off-state. Therefore, the on–off phenomenon should be considered when evaluating disability in patients with IPD, with methods such as the novel-developed disability measurement tool in this study. Full article
(This article belongs to the Special Issue Advances in Sarcopenia: Predictive Biomarkers, Clinical Characteristics, and Therapeutic Strategies)
12 pages, 1728 KiB  
Article
Effects of Intra-Articular Triamcinolone Injection on Adhesive Capsulitis after Breast Cancer Surgery
by Sungwon Kim, Sunwoo Kim, Jong Geol Do and Ji Hye Hwang
Diagnostics 2024, 14(14), 1464; https://doi.org/10.3390/diagnostics14141464 - 9 Jul 2024
Viewed by 1864
Abstract
Purpose: To investigate the effects of intra-articular glenohumeral joint triamcinolone injection in treating secondary adhesive capsulitis after breast cancer surgery. Methods: This study prospectively enrolled 37 participants, including 22 in the breast cancer surgery group and 15 in the idiopathic group. All participants [...] Read more.
Purpose: To investigate the effects of intra-articular glenohumeral joint triamcinolone injection in treating secondary adhesive capsulitis after breast cancer surgery. Methods: This study prospectively enrolled 37 participants, including 22 in the breast cancer surgery group and 15 in the idiopathic group. All participants received intra-articular glenohumeral joint triamcinolone injection in the affected shoulder joint. The clinical outcomes included the Shoulder Pain and Disability Index (SPADI), passive range of motion (PROM), and pain intensity on the Numeric Rating Scale (NRS), which were evaluated before the intervention and 1, 3, and 6 months after. The primary outcome of this study was the mean difference in the total SPADI from baseline to 6 months after the intervention. Results: The mean differences in the total SPADI scores from baseline to 6 months after the intervention were 36.2 ± 16.4 and 47.9 ± 15.2 in the breast cancer surgery group and the idiopathic group, respectively. There was no significant difference between the two groups (p = 0.1495). However, the improvements in the SPADI pain subscale at the 3- and 6-month follow-up visits (−31.2 vs. −48.8, p = 0.042; −34.1 vs. −50.7, p = 0.0006) and the PROM of abduction at the 3-month follow-up (52.4 vs. 70.3, p = 0.0072) were inferior in the breast cancer surgery group compared to the idiopathic group. There were no adverse events in either group. Conclusion: Intra-articular triamcinolone injection is an effective and safe treatment option for adhesive capsulitis after breast cancer surgery; however, it has less effect than for idiopathic adhesive capsulitis. Full article
(This article belongs to the Special Issue Advances in Sarcopenia: Predictive Biomarkers, Clinical Characteristics, and Therapeutic Strategies)
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