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Diagnostics
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Diagnosis, Treatment and Management of Eye Diseases, Third Edition
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Diagnosis, Treatment and Management of Eye Diseases, Third Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1466

Special Issue Editor

Prof. Dr. Simona Delia Nicoara

E-Mail Website
Guest Editor
1. Department of Ophthalmology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
2. Emergency County Hospital, 400006 Cluj-Napoca, Romania
Interests: vitreo-retinal surgery; medical retina; retinopathy of prematurity; artificial intelligence in retinal disease; stem cells; genetics in ophthalmology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, significant progress has been achieved in the diagnosis and management of eye diseases. Optical coherence tomography, progress in ophthalmic surgical technology, gene therapy, regenerative cellular therapies, nanotechnology, development of new molecules to target various ocular tissues and pathogenetic mechanisms, and artificial intelligence offer new tools to diagnose and treat ocular diseases in a multidisciplinary approach. This Special Issue focuses on the methods currently available to diagnose and treat various eye conditions, with a view to future developments and their potential to improve ophthalmological care. Original articles and reviews from all subspecialties of ophthalmology are welcome, with an emphasis on recent advances in diagnosis and therapy. The goal of this Special Issue is to publish articles from clinical, but also from experimental research with an impact on the diagnosis and treatment of eye diseases with a multidisciplinary approach.

Prof. Dr. Simona Delia Nicoara
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical coherence tomography
  • artificial intelligence
  • gene therapy
  • nanotechnology
  • stem cells
  • vitreo-retinal surgery
  • corneal transplantation
  • minimally invasive glaucoma surgery
  • cataract surgery
  • retinopathy of prematurity

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Related Special Issues

Published Papers (2 papers)

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Research

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12 pages, 1618 KB  
Article
Functional and Anatomical Micro-Structural Recovery of Idiopathic Macular Holes Following the Inverted Internal Limiting Membrane Flap Technique: A Long-Term Study
by Kai-Ling Peng, Ya-Hsin Kung and Tsung-Tien Wu
Diagnostics 2025, 15(23), 2961; https://doi.org/10.3390/diagnostics15232961 - 22 Nov 2025
Viewed by 356
Abstract
Background: Idiopathic macular holes (MHs) are typically treated with pars plana vitrectomy and internal limiting membrane (ILM) peeling. The inverted ILM flap (ILMF) technique has emerged for MHs, but long-term outcome data remain inadequately established. This study evaluates the long-term functional and [...] Read more.
Background: Idiopathic macular holes (MHs) are typically treated with pars plana vitrectomy and internal limiting membrane (ILM) peeling. The inverted ILM flap (ILMF) technique has emerged for MHs, but long-term outcome data remain inadequately established. This study evaluates the long-term functional and anatomical outcomes of the ILMF in idiopathic MHs. Methods: We evaluated 71 consecutive eyes of patients with idiopathic MHs who underwent vitrectomy with the inverted ILMF. Follow-up duration was more than 12 months. Visual acuity was measured, and macular anatomy was monitored with optic coherence tomography (OCT). Long-term visual and anatomical outcomes were defined a priori and analyzed accordingly. Results: Final vision values showed significant improvement compared to preoperative ones, from 1.02 [Snellen Equivalent (SE), 19/200] ± 0.40 logarithm of the minimum angle of resolution (logMAR) to 0.47 (SE, 68/200) ± 0.39 logMAR (p < 0.001). The primary MH closure rates were 94.37% (67/71), while the secondary closure rate reached 97.18% (69/71). Factors associated with better final vision included smaller hole size, favorable hole stage, better preoperative vision, intact postoperative foveal microstructure and contour. The recovery of the external limiting membrane (ELM), inner and outer segment junction (IS/OS), and good foveal contour had improved to 73.4%, 40.3%, and 49.3% at one year and 80%, 71.4%, and 53.3% at three years postoperatively, respectively. Conclusions: In idiopathic MHs, the ILMF approach provides meaningful, long-term visual and microstructural recovery, especially with a favorable functional outcome and intact postoperative microstructure sustaining up to three years. Full article
(This article belongs to the Special Issue Diagnosis, Treatment and Management of Eye Diseases, Third Edition)
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Review

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20 pages, 458 KB  
Review
The Role of OCTA and Microperimetry in Revealing Retinal and Choroidal Perfusion and Functional Changes Following Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment: A Narrative Review
by Dan-Grigore Dunca and Simona-Delia Nicoară
Diagnostics 2025, 15(19), 2422; https://doi.org/10.3390/diagnostics15192422 - 23 Sep 2025
Viewed by 787
Abstract
Background: Rhegmatogenous retinal detachment (RRD), the most common type of retinal detachment, requires prompt surgery to reattach the retina and avoid permanent vision loss. While surgical treatment is adapted to each individual case, one frequent option is pars plana vitrectomy (PPV) with [...] Read more.
Background: Rhegmatogenous retinal detachment (RRD), the most common type of retinal detachment, requires prompt surgery to reattach the retina and avoid permanent vision loss. While surgical treatment is adapted to each individual case, one frequent option is pars plana vitrectomy (PPV) with silicone oil (SO) tamponade. Despite achieving anatomical success (complete retinal attachment), concerns persist regarding potential microvascular alterations in the retina and choroid, with a negative impact on visual function. Optical coherence tomography angiography (OCTA) allows detailed, in-depth imaging of retinal and choroidal circulation, whereas microperimetry makes it possible to accurately assess macular function. This review aims to strengthen the existing evidence on vascular and functional alterations at the macular level after SO tamponade in cases of RRD. Methods: A narrative review was conducted using a structured approach, utilizing a PubMed search from January 2000 up to April 2025. Twenty-three studies on OCTA and microperimetry after SO tamponade for RRD were included. Data on vessel densities, choroidal vascular index (CVI), foveal avascular zone (FAZ) size, and retinal sensitivity were extracted and qualitatively analyzed. Results: Studies consistently reported a reduction in the vessel density within the superficial capillary plexus (SCP) under SO tamponade, with partial but incomplete reperfusion post-removal. Choroidal perfusion and CVI were also decreased, exhibiting a negative correlation with the duration of SO tamponade. Microperimetry demonstrated significant reductions in retinal sensitivity (~5–10 dB) during SO tamponade, which modestly improved (~1–2 dB) following removal but generally remaining below normal levels. Conclusions: SO tamponade causes substantial retinal and choroidal vascular impairment and measurable macular dysfunction, even after anatomical reattachment of the retina. It is recommended to perform early SO removal (~3–4 months) and implement routine monitoring by OCTA and microperimetry with the aim of optimizing patient outcomes. Future research should focus on investigating protective strategies and enhancing visual rehabilitation following RRD repair. Full article
(This article belongs to the Special Issue Diagnosis, Treatment and Management of Eye Diseases, Third Edition)
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