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Diagnostics
Special Issues
Recent Advances in Clinical Biochemical Testing
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Recent Advances in Clinical Biochemical Testing

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 5362

Special Issue Editor

Dr. Aw Tar-Choon

E-Mail Website
Guest Editor
Department of Laboratory Medicine, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore
Interests: endocrine biomarkers (thyroid disease, diabetes); cardiac biomarkers (troponin, BNP, Galactin3, Lipids); COVID-19 biomarkers (antibodies, antigen); cancer biomarkers (HE4, circulating tumor cells); lab management (POCT, accreditation, LEAN)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to provide a comprehensive overview of the latest developments and innovations in the field of clinical biochemical testing. This special issue will cover a wide range of topics related to the advancement of biochemical testing, including but not limited to novel biomarkers, advanced analytical techniques, and emerging technologies in the field of clinical biochemistry. The scope of this special issue encompasses research articles, review papers, and original studies that highlight the significant contributions and impact of biochemical testing on clinical diagnosis, disease monitoring, and personalized medicine.

The papers included in this special issue will provide valuable insights into the current state of the art in clinical biochemical testing and offer perspectives on future directions and potential applications in the field. Researchers, healthcare professionals, and industry experts are invited to contribute to this special issue to facilitate knowledge exchange and promote advancements in clinical biochemistry.

Dr. Aw Tar-Choon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical chemistry
  • diagnostic testing
  • biomarkers
  • point-of-care testing
  • mass spectrometry
  • immunoassays
  • microfluidics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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9 pages, 1305 KiB  
Article
Preanalytical Impact of Incomplete K2EDTA Blood Tube Filling in Molecular Biology Testing
by Marco Benati, Laura Pighi, Elisa Paviati, Sara Visconti, Giuseppe Lippi and Gian Luca Salvagno
Diagnostics 2024, 14(17), 1934; https://doi.org/10.3390/diagnostics14171934 - 2 Sep 2024
Viewed by 1899
Abstract
Background and aims: The aim of this study was to investigate the possible preanalytical effect of incomplete filling of blood tubes on molecular biology assays. Materials and methods: The study population consisted of 13 healthy volunteers from whom 11 mL of whole blood [...] Read more.
Background and aims: The aim of this study was to investigate the possible preanalytical effect of incomplete filling of blood tubes on molecular biology assays. Materials and methods: The study population consisted of 13 healthy volunteers from whom 11 mL of whole blood was collected and then distributed in different volumes (1.5, 3.0, and 6.0 mL, respectively) into three 6.0 mL spray-dried and evacuated K2EDTA blood tubes. Automated RNA extraction was performed using the Maxwell® CSC RNA Blood Kit. DNA was extracted with a MagCorePlusII, with concomitant measurement of glyceralde-hyde-3-phosphate dehydrogenase (GAPDH) gene expression. The nucleic acid concentration was calculated using the NanoDrop 1000 spectrophotometer, and purity was assessed using A260/280 and A260/230 absorbance ratios. Results: The RNA concentration was higher in the tubes filled with 1.5 and 3.0 mL of blood than in the reference 6 mL filled tube. The RNA 260/280 and RNA 260/230 ratios did not differ significantly between the differently filled blood tubes. The DNA concentration remained constant in the differently filled tubes. Compared to the 6.0 mL reference filled tube, the 1.5 mL and 3.0 mL filled blood tubes displayed a lower DNA 260/280 nm ratio. The DNA 260/230 ratio did not differ significantly in any of the variously filled tubes. Compared to the 6.0 mL reference filled blood tube, the 1.5 mL and 3.0 mL filled blood tubes showed a significant increase in the GAPDHcycle threshold. Conclusions: Our results suggest that underfilling of K2EDTA blood tubes may be a modest but analytically significant source of bias in molecular biology testing. Full article
(This article belongs to the Special Issue Recent Advances in Clinical Biochemical Testing)
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Review

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12 pages, 514 KiB  
Review
Laboratory Tests, Bacterial Resistance, and Treatment Options in Adult Patients Hospitalized with a Suspected Urinary Tract Infection
by Paul Froom and Zvi Shimoni
Diagnostics 2024, 14(11), 1078; https://doi.org/10.3390/diagnostics14111078 - 22 May 2024
Cited by 2 | Viewed by 2049
Abstract
Patients treated for systemic urinary tract infections commonly have nonspecific presentations, and the specificity of the results of the urinalysis and urine cultures is low. In the following narrative review, we will describe the widespread misuse of urine testing, and consider how to [...] Read more.
Patients treated for systemic urinary tract infections commonly have nonspecific presentations, and the specificity of the results of the urinalysis and urine cultures is low. In the following narrative review, we will describe the widespread misuse of urine testing, and consider how to limit testing, the disutility of urine cultures, and the use of antibiotics in hospitalized adult patients. Automated dipstick testing is more precise and sensitive than the microscopic urinalysis which will result in false negative test results if ordered to confirm a positive dipstick test result. There is evidence that canceling urine cultures if the dipstick is negative (negative leukocyte esterase, and nitrite) is safe and helps prevent the overuse of urine cultures. Because of the side effects of introducing a urine catheter, for patients who cannot provide a urine sample, empiric antibiotic treatment should be considered as an alternative to culturing the urine if a trial of withholding antibiotic therapy is not an option. Treatment options that will decrease both narrower and wider spectrum antibiotic use include a period of watching and waiting before antibiotic therapy and empiric treatment with antibiotics that have resistance rates > 10%. Further studies are warranted to show the option that maximizes patient comfort and safety. Full article
(This article belongs to the Special Issue Recent Advances in Clinical Biochemical Testing)
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