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Diagnostics
Special Issues
Insights into Perinatal Medicine and Fetal Medicine
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Insights into Perinatal Medicine and Fetal Medicine

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2454

Special Issue Editors

Dr. Paola Quaresima

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Guest Editor
Unit of Obstetrics and Gynaecology, Department of Clinical and Experimental Medicine, "Magna Græcia" University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
Interests: perinatal medicine; fetal medicine
Dr. Ilaria Fantasia

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Guest Editor
Obsteric & Gynecology Unit, San Salvatore Hospital, L’Aquila, Italy
Interests: perinatal medicine; fetal medicine

Special Issue Information

Dear Colleagues,

Fetal and perinatal medicine are branches of obstetrics and gynecology focusing on the management of complications that the mother and fetus may experience before, during and immediately after birth. It is a very broad field that involves either the pregnant woman, the fetus, or both as a single entity in which the complications of one can impact the other.

In recent years, advances in research and technology have allowed for significant improvement in perinatal care, ranging from early screening of fetal and maternal complications, such as fetal aneuploidies and preeclampsia, up to the in utero treatment of fetal complications through minimally invasive approaches, such as laser coagulation of placental anastomosis in monochorionic twin pregnancies or antenatal spinal defect treatment. A multidisciplinary approach is, therefore, essential and is based on the collaboration between the fetal medicine specialist, geneticists and pediatric surgeons.

Furthermore, the rate of advanced maternal age, use of assisted reproduction techniques, and overweight/obesity among women has increased the number of high-risk pregnancies with implications on both the fetal and the maternal side, such as fetal growth restriction, gestational diabetes and hypertensive disorders of pregnancy.

The aim of this Special Issue is to gather relevant scientific information in the field of perinatal and fetal medicine with the aim of supporting the clinician in the daily management of maternal–fetal complications.

This Special Issue will include (but is not limited to):

  • First trimester screening for fetal aneuploidies (combined test, cell free DNA test);
  • Increased nuchal translucency and genetic implications;
  • First trimester screening for pre-eclampsia;
  • Fetal malformations;
  • Hypertensive disorder of pregnancy;
  • Gestational diabetes;
  • Fetal growth;
  • In utero surgery.

Randomized Controlled Trials (RCTs), reviews, meta-analyses, cohort studies, and case reports, are welcome.

Dr. Paola Quaresima
Dr. Ilaria Fantasia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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10 pages, 458 KiB  
Article
Association between White Matter T2 Hyper-Intense Signals in Fetal Brain Magnetic Resonance Imaging and Neurodevelopment of Fetuses with Cytomegalovirus Infection
by Galia Barkai, Eldad Katorza, Simon Lassman, Itachi Levinberg, Chen Hoffmann and Omer Bar-Yosef
Diagnostics 2024, 14(8), 797; https://doi.org/10.3390/diagnostics14080797 - 11 Apr 2024
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Abstract
An association between subtle changes in T2 white matter hyper-intense signals (WMHSs) detected in fetal brain magnetic resonance imaging (fbMRI) and congenital cytomegalovirus (CMV) infection has been established. The research aim of this study is to compare children with congenital CMV infection with [...] Read more.
An association between subtle changes in T2 white matter hyper-intense signals (WMHSs) detected in fetal brain magnetic resonance imaging (fbMRI) and congenital cytomegalovirus (CMV) infection has been established. The research aim of this study is to compare children with congenital CMV infection with neurodevelopment outcome and hearing deficit with and without WMHSs in a historic prospective case study cohort of 58 fbMRIs. Of these, in 37 cases, fbMRI was normal (normal group) and WMHSs were detected in 21 cases (WMHS group). The median infection week of the WMHS group was earlier than the normal fbMRI group (8 and 17 weeks of gestation, respectively). The proportion of infants treated with valganciclovir in the WMHS group was distinctly higher. Hearing impairment was not significantly different between the groups. VABS scores in all four domains were within normal range in both groups. The median score of the motor skills corrected for week of infection was better in the WMHS group. A multivariate analysis using the week of infection interaction variable of WMHS and valganciclovir treatment showed better motor score outcomes in the valganciclovir treatment group despite an earlier week of infection. WMHSs were not associated with neurodevelopmental outcome and hearing deficit. In our cohort, valganciclovir treatment may have a protective effect on fetuses with WMHSs by improving neurodevelopmental outcome. Full article
(This article belongs to the Special Issue Insights into Perinatal Medicine and Fetal Medicine)
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12 pages, 6328 KiB  
Article
Agreement between Fetal Brain Ultrasonography and Magnetic Resonance Imaging in the Measurements of the Corpus Callosum and Transverse Cerebellar Diameter
by Shai Bookstein, Noy Nachmias and Eldad Katorza
Diagnostics 2024, 14(4), 366; https://doi.org/10.3390/diagnostics14040366 - 7 Feb 2024
Viewed by 685
Abstract
As the use of magnetic resonance imaging of the fetal brain has evolved, the need to understand its efficiency in the biometry of the fetal brain has broadened. This study aimed to assess the level of agreement and correlation between the two cardinal [...] Read more.
As the use of magnetic resonance imaging of the fetal brain has evolved, the need to understand its efficiency in the biometry of the fetal brain has broadened. This study aimed to assess the level of agreement and correlation between the two cardinal imaging methods of fetal neuroimaging, ultrasonography (US) and magnetic resonance imaging (MRI), by measuring the corpus callosum (CC) and transverse cerebellar diameter (TCD) in terms of length and percentile. Measurements of CC and TCD length and percentile were documented over a 7-year span in a tertiary referral medical center. All US and MRI examinations were performed in the customary planes and subcategorized by valid reference charts. Exclusion and inclusion criteria were set before the collection and processing of the data. A total of 156 fetuses out of 483 were included in the study. A positive, strong correlation and agreement were found (r = 0.78; ICC = 0.76) between US and MRI in TCD measurements. For CC length measurement, a moderate correlation and moderate agreement (r = 0.51; ICC = 0.49) between US and MRI was observed. TCD and CC percentiles had lower levels of correlation and agreement compared with the length variables. Our study indicates good agreement between MRI and US in the assessment of TCD measurement as a part of antenatal neuroimaging. Furthermore, while the two techniques are not always compatible, they are complementary methods. Full article
(This article belongs to the Special Issue Insights into Perinatal Medicine and Fetal Medicine)
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11 pages, 3014 KiB  
Case Report
Surgical Conservative Management of a Retained Placenta after Angular Pregnancy, a Case Report and Literature Review
by Giovanna Bitonti, Paola Quaresima, Giampiero Russo, Costantino Di Carlo, Giuseppina Amendola, Rosanna Mazzulla, Roberta Venturella and Michele Morelli
Diagnostics 2023, 13(23), 3492; https://doi.org/10.3390/diagnostics13233492 - 21 Nov 2023
Viewed by 874
Abstract
Angular pregnancies are rare and difficult to diagnose. Evidence suggests they are associated with a higher risk of intrauterine growth restriction and abnormal third stage of labor due to a retained placenta. The lack of standardized AP diagnostic criteria impacts on their correct [...] Read more.
Angular pregnancies are rare and difficult to diagnose. Evidence suggests they are associated with a higher risk of intrauterine growth restriction and abnormal third stage of labor due to a retained placenta. The lack of standardized AP diagnostic criteria impacts on their correct identification and makes the treatment of potential complications challenging. We present a case of the successful conservative surgical management of a retained placenta after a term AP also complicated by intrauterine growth restriction. Moreover, to identify the best evidence regarding AP diagnostic criteria and retained placenta therapeutic approaches, we have realized an expert literature review. Full article
(This article belongs to the Special Issue Insights into Perinatal Medicine and Fetal Medicine)
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