Diagnosis and Factors Associated with Perinatal Health, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 755

Special Issue Editors


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Guest Editor
Department of Nursing, Faculty of Health Sciences of Ceuta, University of Granada, 51005 Ceuta, Spain
Interests: pregnant health

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Guest Editor
Faculty of Health Sciences, Department of Nursing, Universidad de Granada, Granada, Spain
Interests: effects of prenatal stress on pregnant women and their offspring; hair cortisol levels; infant's neurodevelopment; psychological stress during pregnancy
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Special Issue Information

Dear Colleagues, 

The perinatal period is an extremely sensitive time for both the mother and the fetus. During pregnancy, birth, and postpartum, a wide number of variables can impact maternal and neonatal health and disease state. Adverse variables during the perinatal period can be assessed from a medical and/or psychological perspective.

In this respect, the use of technology, apps, electronic devices, and psychological measures can contribute to the screening, assessment, and/or diagnosis of a range of issues for both the mother and the fetus, as well as the partner.

This Special Issue will disseminate studies regarding the perinatal period and the use of tools that support the assessment and diagnosis of women, partners, and neonates at this crucial time. During pregnancy, environmental circumstances (including exposure to a war, intimate partner violence, or a pandemic) can affect maternal and neonatal health. The environment pregnant women are exposed to can permanently affect fetal physiology for the child’s entire life. In this respect, the developmental origin of health and disease (DOHaD) theory (also known as fetal programming hypothesis) that occurs during perinatal development will determine the health and disease of that individual throughout their extrauterine life through epigenetics.

Dr. Luciano Rodríguez Díaz
Dr. Rafael A. Caparros-Gonzalez
Guest Editors

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Keywords

  • perinatal medicine
  • perinatal psychology
  • assessment
  • fetal development
  • the developmental origin of health and disease
  • fetal programming
  • epigenetic
  • pregnancy

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Published Papers (2 papers)

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Research

12 pages, 626 KiB  
Article
Perinatal Outcomes Related to the Presence of a Nuchal Cord During Delivery: A Retrospective Cohort Study
by Gabriel Viana Silva, Carolina Toledo Gontijo, Ana Paola Cruz Lunguinho, Mário Sérgio Gomes Caetano, Gustavo Yano Callado, Edward Araujo Júnior and Alberto Borges Peixoto
Diagnostics 2025, 15(10), 1197; https://doi.org/10.3390/diagnostics15101197 - 9 May 2025
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Abstract
Objective: To evaluate and compare whether the presence of a nuchal cord (NC) and its characteristics had a negative impact on perinatal outcomes during delivery. Methods: This was a retrospective cohort study that analyzed the medical records of pregnant women from [...] Read more.
Objective: To evaluate and compare whether the presence of a nuchal cord (NC) and its characteristics had a negative impact on perinatal outcomes during delivery. Methods: This was a retrospective cohort study that analyzed the medical records of pregnant women from March 2020 to June 2023. Pregnant women were divided into groups with and without an NC. Singleton pregnancies ≥ 37 weeks were included, excluding fetal malformations, chromosomal anomalies, and cases with missing data and cord blood gas. Results: Of the 3364 medical records analyzed, 466 were included—366 without and 100 with an NC. Among the cases with an NC, 91% had one loop and 9% had ≥ two loops; 82% were loose and 18% were tight. Pregnant women with an NC had a higher gestational age (39.7 vs. 39.1 weeks, p = 0.006), fewer deliveries (1.0 vs. 2.0, p = 0.035), and a higher prevalence of cesarean sections (99% vs. 60.4%, p < 0.001). An NC was associated with a lower Apgar score at the 1st minute (8 vs. 9, p = 0.014) and higher arterial cord blood pH (7.27 vs. 7.24, p = 0.020). The presence of a tight cord was significantly associated with a 7.52-fold increased risk of an Apgar score < 7 at the 1st minute [x2(1) = 5.92, OR: 7.52, 95% CI: 1.51–37.31, R2 Nagelkerke: 0.14, p = 0.014]. Conclusions: There was no effect of the presence of an NC on adverse perinatal outcomes. However, the presence of a tight NC was associated with an increased risk of an Apgar score < 7 at the 1st minute, but no other effect on neonatal outcomes. Full article
(This article belongs to the Special Issue Diagnosis and Factors Associated with Perinatal Health, 2nd Edition)
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12 pages, 624 KiB  
Article
Incidence and Risk Factors of White Matter Lesions in Moderate and Late Preterm Infants
by Kentaro Ueda, Kennosuke Tsuda, Takaharu Yamada, Shin Kato, Sachiko Iwata, Shinji Saitoh and Osuke Iwata
Diagnostics 2025, 15(7), 881; https://doi.org/10.3390/diagnostics15070881 - 1 Apr 2025
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Abstract
Background: Moderate and late preterm infants (32–36 weeks of gestation) are at significant risk of developmental impairments. Incidence of white matter lesions, which are associated with developmental impairments in very preterm infants, remains underreported in this population. This study aimed to assess [...] Read more.
Background: Moderate and late preterm infants (32–36 weeks of gestation) are at significant risk of developmental impairments. Incidence of white matter lesions, which are associated with developmental impairments in very preterm infants, remains underreported in this population. This study aimed to assess the incidence and clinical risk factors associated with brain lesions, particularly white matter lesions, in moderate and late preterm infants using term-equivalent MRI. Methods: This prospective observational study included 195 preterm infants born at 32+0–36+6 weeks of gestation and admitted to a tertiary NICU between 2019 and 2020. MRI findings at term-equivalent age were evaluated. Clinical risk factors were analysed using logistic regression. Results: Among the 195 infants, 23.6% had brain lesions on MRI, with white matter lesions (73.9%), specifically punctate white matter lesions, being the most common form of lesions. Vaginal delivery (odds ratio (OR) = 3.102, 95% confidence interval (CI) = 1.250–7.696, p = 0.015), larger birth weight z-scores (OR = 1.702, 95% CI = 1.118–2.591, p = 0.013), and intubation (OR = 2.948, 95% CI = 1.269–6.850, p = 0.012) were significant risk factors for white matter lesions. Conclusions: White matter lesions, particularly punctate white matter lesions, are common in moderate and late preterm infants. These lesions are associated with perinatal factors suggestive of delayed transition and inflammation. Future research should focus on detailed clinical care measures and neurodevelopmental assessments to identify modifiable risk factors for brain injury. Full article
(This article belongs to the Special Issue Diagnosis and Factors Associated with Perinatal Health, 2nd Edition)
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