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Diagnostics
Special Issues
New Insights into Maternal-Fetal Medicine: Diagnosis and Management
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New Insights into Maternal-Fetal Medicine: Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 758

Special Issue Editor

Dr. Monika Szpotanska-Sikorska

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Interests: obstetrics; pregnancy; pregnancy complications; liver transplantation; organ transplantation; kidney transplantation

Special Issue Information

Dear Colleagues,

As maternal-fetal medicine remains a top public health priority globally, there is an urgent need to integrate and disseminate new research findings to inform clinical practice and improve outcomes.

The purpose of this special issue is to highlight cutting-edge research and innovative approaches in the field of maternal-fetal medicine that can enhance the quality of care for pregnant individuals, improve pregnancy outcomes, and support the health and well-being of both mothers and newborns. We hope to bridge the gap between research and clinical application by focusing on interdisciplinary research, including advances in prenatal screening, management of high-risk pregnancies, and the impact of maternal health on fetal development.

Dr. Monika Szpotanska-Sikorska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • maternal medicine
  • fetal medicine
  • placenta
  • prenatal screening
  • pregnancy

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Published Papers (1 paper)

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Research

12 pages, 679 KiB  
Article
Exploring the Role of miRNA-101a in the Circulatory System’s Adaptive Mechanisms in Hypertensive Disorders of Pregnancy
by Ewa Szczerba, Eliza Kozyra-Pydyś, Agnieszka Zajkowska, Katarzyna Pankiewicz, Grzegorz Szewczyk, Tomasz Maciejewski, Maciej Małecki and Anna Fijałkowska
Diagnostics 2025, 15(5), 535; https://doi.org/10.3390/diagnostics15050535 - 22 Feb 2025
Viewed by 528
Abstract
Background/Objectives: Hypertensive disorders of pregnancy constitute one of the principal reasons for maternal and perinatal morbidity and mortality worldwide. Identification of molecular mechanisms causing placental dysfunction resulting in gestational hypertension is crucial in the development of new methods of prevention and treatment. The [...] Read more.
Background/Objectives: Hypertensive disorders of pregnancy constitute one of the principal reasons for maternal and perinatal morbidity and mortality worldwide. Identification of molecular mechanisms causing placental dysfunction resulting in gestational hypertension is crucial in the development of new methods of prevention and treatment. The aim of this case-control study was to assess changes in miRNA expression, and biomarkers such as NT-proBNP and galectin-3, in women with uncomplicated pregnancies and hypertensive disorders of pregnancy. Methods: This was a case-control study. We included 61 women with uncomplicated pregnancies and 31 women with hypertensive disorders of pregnancy (21 women with gestational hypertension and 10 women with chronic hypertension). Blood sample collection was performed at 33 weeks of gestation. Expression and expression levels of 26 microRNAs, NTproBNP, and galectin-3 were measured. Results: Lower expression of microRNA 101a was observed in patients with hypertensive disorders of pregnancy. The expression of microRNA 101a was significantly lower in the group of patients with gestational hypertension, but not with chronic hypertension. Not only was the expression of microRNA 101a lower in all women with gestational hypertension but also in XYZ% it reached undetectable levels. Other studied microRNAs were similar in expression and concentration levels among both groups. In all women with hypertensive disorders of pregnancy, statistically significant correlations were detected between NT-proBNP concentrations and microRNA 133a (r = −0.68; p = 0.030) and microRNA 195 (r = 0.67; p = 0.030), and between galectin-3 and microRNA 195 (r = 0.46; p = 0.010), microRNA 133a (r = 0.44; p = 0.020), microRNA 222-2276 (r = 0.39; p = 0.050). Conclusions: microRNA 101a, a molecule associated with placental dysfunction in preeclampsia and with inhibition of cardiac fibrosis, has lower expression and concentration levels in gestational hypertension but not in chronic hypertension. Full article
(This article belongs to the Special Issue New Insights into Maternal-Fetal Medicine: Diagnosis and Management)
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