Neurodegenerative Disease and Cognitive Impairment in Neurological Pathologies – Diagnosis and Management

Dear Colleagues,

Neurodegenerative diseases represent a generic term for a series of conditions that affect neurons. Neurons are basically the "foundation stone" of the nervous system that cannot be replaced. Neurodegenerative diseases are incurable diseases that lead to the progressive degeneration and death of nerve cells.

Among others, Alzheimer's, Huntington's and Parkinson's diseases affect more than 45 million people worldwide. They usually appear as we get older and unfortunately the treatment has limits.

Patients suffering from these disorders experience changes both in terms of mood and cognitive level.

The impact is also felt by the family and friends of the patient, and it is more difficult, since these conditions cannot be cured. Through studies on laboratory animals and human subjects, it was tried to reduce the evolution of diseases and discover the exact causes and appropriate treatments.

In addition, it has been identified important similarities between neurodegenerative disorders made in the fields of genetics, biochemistry, and cell biology. All these efforts revealed the presence of abnormal proteins and raised questions about how these proteins interfere with normal cellular functions and how they spread in the brain.

Additionally, cognitive disorders associated with neurological diseases such as epilepsy can have a negative impact on the quality of life. The relationship between epilepsy and memory disorders is complex and multifactorial and differs from one person to another.

This Special Issue welcomes submissions of original research and review articles related to any aspect of the diagnosis, molecular mechanisms and pathogenesis of neurodegenerative diseases or cognitive impairment associated with neurological pathologies, as well as the follow-up and features of novel biomarkers and treatment options.

Dr. Ionica Pirici
Guest Editor

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• cognitive disorder
• Parkinson disease
• epilepsy
• Alzheimer disease