Diagnosis of Spleen Disorders

Dear Colleagues, 

The spleen is a small fist-sized organ that lies behind the stomach on the left side of the abdomen, participating mainly in hematologic and immune homeostasis. It filters the blood, removing old and damaged blood cells, and, being the largest lymphatic organ, provides active immune response through humoral and cell-mediated pathways.

A number of diseases and infections may affect this organ, and a careful differential diagnosis is essential to determining the underlying causes of spleen disorders. Hemolytic diseases, infections, and cancers can cause the spleen to enlarge. Regardless of organ size, hypersplenism is a condition in which the spleen is overactive and the normal process of destruction of cellular blood elements is exaggerated because of reticuloendothelial hyperplasia.

If splenomegaly occurs, it can usually be detected during a physical examination. Additionally, blood tests, bone marrow biopsy, and imaging techniques such as ultrasound, CT, and MRI scan can be administered to confirm diagnosis.

This Special Issue welcomes contributions covering the current aspects of diagnosis of spleen disorders. Submissions may include articles of current original research, new experimental methodology, and/or review articles summarizing the current state of the art for clinical diagnosis of spleen disorders that clinicians, pathologists, and basic science investigators may find informative.

Prof. Dr. Michele De Rosa
Guest Editor

Manuscript Submission Information

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