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Diagnostics
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Pancreas Diseases: Diagnosis and Management
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Pancreas Diseases: Diagnosis and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 8641

Special Issue Editors

Dr. Truptesh H. Kothari

E-Mail Website
Guest Editor
Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14642, USA
Interests: diagnosis; gastroenterology; hepatology; interventional endoscopic ultrasound
Dr. Thiruvengadam Muniraj

E-Mail Website
Guest Editor
Yale School of Medicine, Yale University, New Haven, CT 06510-8019, USA
Interests: digestive diseases; pancreatitis; endoscopy

Special Issue Information

Dear Colleagues,

Our goal for this Special Issue is to provide a broad spectrum of studies on the diagnosis and management of pancreases diseases—from benign to malignant. Submissions should focus on a specific pancreas etiology and demonstrate evidence-based medicine related to the diagnosis and management of that specific disease process. We encourage authors to include references from the last 5–10 years. 

We hope that this special edition will be helpful in educating our readers and providing a current perspective on hot topics in this field.

Dr. Truptesh H. Kothari
Dr. Thiruvengadam Muniraj
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreas diseases
  • diagnosis
  • evidence-based medicine
  • malignant diseases

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Review

16 pages, 2996 KiB  
Review
Diagnosis and Management of Acute Pancreatitis
by Nitish Mittal, Veeral M. Oza, Thiruvengadam Muniraj and Truptesh H. Kothari
Diagnostics 2025, 15(3), 258; https://doi.org/10.3390/diagnostics15030258 - 23 Jan 2025
Viewed by 3195
Abstract
Acute pancreatitis is an inflammatory condition of the exocrine pancreas that is a common indication for hospital admission and has had an increasing incidence in the last few decades. The diagnosis of acute pancreatitis requires the satisfaction of two out of three criteria: [...] Read more.
Acute pancreatitis is an inflammatory condition of the exocrine pancreas that is a common indication for hospital admission and has had an increasing incidence in the last few decades. The diagnosis of acute pancreatitis requires the satisfaction of two out of three criteria: (1) abdominal pain radiating to the back, (2) serum lipase or amylase levels three or more times the upper limit of the normal level, and (3) findings indicating pancreatitis obtained via a computed tomography (CT) scan or magnetic resonance imaging (MRI). The different etiologies include gallstones, autoimmune disorders, alcohol abuse, smoking, hypertriglyceridemia, obesity, drugs, and post-endoscope retrograde cholangiopancreatography (ERCP). The initial investigation includes serum amylase and lipase analysis, a lipid panel including triglycerides, analysis of immunoglobulins, a full blood count, electrolyte analysis, a hemoglobin A1c test, a complete metabolic panel, and transabdominal ultrasound. The initial therapy includes oxygen supplementation, the provision of intravenous fluids, pain control, and a nutrition regime. Early oral feeding is encouraged if tolerated; if not, liquid supplement provision or enteral tube feeding within 48 h of admission has shown better outcomes. Some complications of acute pancreatitis are necrosis, infection, insulin resistance leading to diabetes mellitus, and pancreatic exocrine insufficiency requiring enzyme supplementation. Patients need to attend regular follow-ups and abstain from alcohol and smoking (if warranted) to prevent the recurrence of acute pancreatitis. The mortality rate of acute pancreatitis has decreased in the past few decades because of better management skills, but the recent rise in acute pancreatitis episodes is concerning. Sustained endeavors through clinical trials are required to establish a broad variety of drugs that can be used for acute pancreatitis episodes. Full article
(This article belongs to the Special Issue Pancreas Diseases: Diagnosis and Management)
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13 pages, 890 KiB  
Review
Role of Endoscopic Ultrasound in Pancreatic Cancer Diagnosis and Management
by Hayley K. Rogers and Shawn L. Shah
Diagnostics 2024, 14(11), 1156; https://doi.org/10.3390/diagnostics14111156 - 31 May 2024
Cited by 5 | Viewed by 3296
Abstract
The emergence of endoscopic ultrasound (EUS) has significantly impacted the diagnosis and management of pancreatic cancer and its associated sequelae. While the definitive role of EUS for pancreatic cancer remains incompletely characterized by currently available guidelines, EUS undoubtedly offers high diagnostic accuracy, the [...] Read more.
The emergence of endoscopic ultrasound (EUS) has significantly impacted the diagnosis and management of pancreatic cancer and its associated sequelae. While the definitive role of EUS for pancreatic cancer remains incompletely characterized by currently available guidelines, EUS undoubtedly offers high diagnostic accuracy, the precise staging of pancreatic neoplasms, and the ability to perform therapeutic and palliative interventions. However, current challenges to EUS include limited specialized expertise and variability in operator proficiency. As the technology and techniques continue to evolve and become more refined, EUS is poised to play an increasingly integral role in shaping pancreatic cancer care. Full article
(This article belongs to the Special Issue Pancreas Diseases: Diagnosis and Management)
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19 pages, 1652 KiB  
Review
Novel Insights into Postoperative Surveillance in Resected Pancreatic Cystic Neoplasms—A Review
by Daniel Vasile Balaban, Laura-Ioana Coman, Marina Balaban, Raluca Simona Costache and Mariana Jinga
Diagnostics 2024, 14(10), 1056; https://doi.org/10.3390/diagnostics14101056 - 19 May 2024
Viewed by 1660
Abstract
Pancreatic cystic lesions (PCL) are frequently encountered in clinical practice and some are referred to surgery due to their neoplastic risk or malignant transformation. The management of PCL involves complex decision-making, with postoperative surveillance being a key component for long-term outcomes, due to [...] Read more.
Pancreatic cystic lesions (PCL) are frequently encountered in clinical practice and some are referred to surgery due to their neoplastic risk or malignant transformation. The management of PCL involves complex decision-making, with postoperative surveillance being a key component for long-term outcomes, due to the potential for recurrence and postoperative morbidity. Unfortunately, the follow-up of resected patients is far from being optimal and there is a lack of consensus on recommendations with regard to timing and methods of surveillance. Here, we summarize the current knowledge on the postoperative surveillance of neoplastic pancreatic cysts, focusing on the mechanisms and risk factors for recurrence, the recurrence rates according to the initial indication for surgery, the final result of the surgical specimen and neoplastic risk in the remaining pancreas, as well as the postsurgical morbidity comprising pancreatic exocrine insufficiency, metabolic dysfunction and diabetes after resection, according to the type of surgery performed. We analyze postsurgical recurrence rates and morbidity profiles, as influenced by different surgical techniques, to better delineate at-risk patients, and highlight the need for tailored surveillance strategies adapted to preoperative and operative factors with an impact on outcomes. Full article
(This article belongs to the Special Issue Pancreas Diseases: Diagnosis and Management)
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