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Diagnostics
Special Issues
Precision Diagnosis and Management in Kidney Transplantation
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Precision Diagnosis and Management in Kidney Transplantation

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1456

Special Issue Editors

Dr. Cheng Yang

E-Mail Website
Guest Editor
Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
Interests: kidney; transplantation; immunology; fibrosis; kidney injury
Special Issues, Collections and Topics in MDPI journals
Dr. Longshan Liu

E-Mail Website
Guest Editor
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
Interests: antibody mediated rejection; pediatric kidney transplantation
Prof. Dr. Marijn Speeckaert

E-Mail Website
Guest Editor
Department of Internal Medicine, Nephrology Division, Ghent University Hospital, 9000 Ghent, Belgium
Interests: biochemistry; biomarkers; hypertension; cardiovascular disease; kidney disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Based on the rapid development of molecular biology and immunology, precision diagnosis and treatment in kidney transplantation continue to make breakthroughs. Many non-invasive and molecular diagnostic methods have been applied in clinical kidney transplantation, and gene and cell therapy will also usher in a new era of diagnosis and treatment in the future. Based on this, this Special Issue hopes to present recent progress in this area of medicine in the form of original research and reviews. Potential sub-topics include the following:

1. Novel medical imaging in kidney transplantation theranostics.
2. Molecular diagnostics in kidney transplantation.
3. Diagnostics based on next generation sequencing or multi-omics.
4. Cutting-edge genes and therapy in kidney transplantation.

Dr. Cheng Yang
Dr. Longshan Liu
Prof. Dr. Marijn Speeckaert
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney transplantation
  • molecular diagnosis
  • immune repertoire
  • single cell sequencing
  • multi-omics sequencing
  • radiology
  • ultrasound
  • stem cell
  • gene and cell therapy

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Published Papers (1 paper)

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Research

11 pages, 1935 KiB  
Article
Integrating Donor Derived Cell-Free DNA Fraction and Absolute Quantification for Enhanced Rejection Diagnosis in Kidney Transplant Recipients
by Weijian Nie, Yan Wang, Qian Fu, Chenglin Wu, Ronghai Deng, Xiaolin Yu, Caiguo Ye, Xiangjun Liu, Bowen Xu, Pingping Sun, Longshan Liu, Jun Li, Huanxi Zhang and Changxi Wang
Diagnostics 2025, 15(3), 237; https://doi.org/10.3390/diagnostics15030237 - 21 Jan 2025
Viewed by 929
Abstract
Background: This study aimed to assess the diagnostic accuracy of combining donor-derived cell-free DNA (dd-cfDNA) fraction and absolute quantification in detecting kidney allograft rejection. Methods: A prospective study was conducted from December 2019 to April 2021 at the First Affiliated Hospital of Sun [...] Read more.
Background: This study aimed to assess the diagnostic accuracy of combining donor-derived cell-free DNA (dd-cfDNA) fraction and absolute quantification in detecting kidney allograft rejection. Methods: A prospective study was conducted from December 2019 to April 2021 at the First Affiliated Hospital of Sun Yat-sen University. Kidney transplant recipients who underwent biopsy, including cases of T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR), and borderline rejection, were included. dd-cfDNA fraction and absolute concentrations were measured, and diagnostic efficacy was evaluated using receiver operating characteristic (ROC) analysis. The double-positive and double-negative methods were applied to assess performance. Results: A total of 50 kidney transplant recipients were included. The dd-cfDNA fraction cutoff of 1.08% achieved 93.33% sensitivity and 91.43% specificity (AUC = 0.95), with an NPV of 96.97% and a PPV of 82.35%. The absolute dd-cfDNA threshold of 32 cp/mL yielded 80.00% sensitivity and 71.43% specificity (AUC = 0.78), with an NPV of 89.29% and a PPV of 54.55%. The double-positive method provided superior accuracy, with a PPV of 91.67% and an NPV of 89.47%, demonstrating 73.33% sensitivity and 97.14% specificity. The double-negative method achieved 100% NPV and 100% sensitivity. Conclusions: Combining dd-cfDNA fraction and absolute quantification improves diagnostic accuracy for kidney transplant rejection, especially ABMR. The double-positive and double-negative approaches show high predictive value, offering potential clinical value for monitoring kidney transplant recipients. Full article
(This article belongs to the Special Issue Precision Diagnosis and Management in Kidney Transplantation)
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