Innovative Therapeutic Strategies, Biomarkers, and Molecular Pathways in Gastrointestinal and Hepatobiliary Cancers

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Gastrointestinal Oncology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 199

Special Issue Editors


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Guest Editor
Department of Medicine, Division of Hematology & Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
Interests: gastric cancer; esophageal cancer; colon cancer; hepatocellular carcinoma; bile duct cancer
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT 05401, USA
Interests: gastrointestinal pathology; anatomic and clinical pathology; molecular genetic pathology

Special Issue Information

Dear Colleagues,

Gastrointestinal and hepatobiliary cancers represent a significant global health challenge due to their high morbidity and mortality rates. This Special Issue explores the latest advancements in therapeutic strategies, emphasizing innovative approaches such as immunotherapy, targeted therapies, and combination treatments. Additionally, it highlights emerging biomarkers that facilitate early diagnosis, prognosis, and personalized medicine. The Special Issue also delves into the molecular pathways driving tumorigenesis, uncovering potential targets for drug development. By bringing together cutting-edge research and clinical insights, this collection aims to inspire breakthroughs in managing and treating these complex malignancies, fostering a deeper understanding of their underlying mechanisms and therapeutic potential.

Dr. Anwaar Saeed
Dr. Azhar Saeed
Guest Editors

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Keywords

  • gastrointestinal cancers
  • hepatobiliary cancers
  • immunotherapy
  • targeted therapies
  • combination treatments
  • biomarkers
  • early diagnosis
  • prognosis
  • personalized medicine
  • molecular pathways
  • drug development targets

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Published Papers (1 paper)

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Review

15 pages, 426 KiB  
Review
Role of Immunotherapy in the Treatment of Hepatocellular Carcinoma
by Irina Y. Dobrosotskaya, Rashmi Kumar and Timothy L. Frankel
Curr. Oncol. 2025, 32(5), 264; https://doi.org/10.3390/curroncol32050264 - 30 Apr 2025
Viewed by 68
Abstract
Hepatocellular carcinoma is the most common primary liver tumor and is strongly related to underlying liver cirrhosis. Common etiologies include viral hepatitis, elevated alcohol consumption and metabolic diseases, all of which result in liver inflammation and scarring. Previously, systemic therapies for locally advanced [...] Read more.
Hepatocellular carcinoma is the most common primary liver tumor and is strongly related to underlying liver cirrhosis. Common etiologies include viral hepatitis, elevated alcohol consumption and metabolic diseases, all of which result in liver inflammation and scarring. Previously, systemic therapies for locally advanced or metastatic disease were limited to tyrosine kinase inhibitors with poor efficacy and rare cures. Recent advances have harnessed the power of the immune system to combat disease, resulting in improved outcomes and occasional cures. Here, we describe the recent clinical trials in immunotherapies for the treatment of hepatocellular carcinoma as first- and second-line therapies and in combination with other drug classes. Full article
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