Delivery Systems for Cosmetics

A special issue of Cosmetics (ISSN 2079-9284).

Deadline for manuscript submissions: closed (31 March 2019) | Viewed by 19402

Special Issue Editor


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Guest Editor
School of Pharmacy, Queen’s University Belfast, Belfast, UK
Interests: 3D Printing; Drug Delivery; Electrospinning; Pharmaceutics; Nanotechnology; Pharmaceutical Manufacturing.

Special Issue Information

Dear Colleagues,

Delivery systems are widely used in cosmetic products, and refer to the formulation technologies used to protect and stabilise the active ingredients put in cosmetics. A delivery system is as crucial to the cosmetic formulation as the actives themselves. A good system preserves valuable skincare actives, without the use of harmful chemicals. A variety of delivery systems have been used or have the potential to be used in the cosmetic formulations, such as lipid nanoparticles, microneedles, patches, and polymeric and emulsion-based delivery systems. This Special Issue will address new developments in the delivery systems for cosmetics, covering recent advantages and future directions in the field, by original research papers and review articles.

Dr. Dimitrios A. Lamprou
Guest Editor

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Keywords

  • cosmetics
  • delivery systems
  • formulation
  • lipids
  • microneedles
  • nanocarriers
  • personal care
  • patches
  • transdermal delivery systems
  • vesicles

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Published Papers (2 papers)

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Research

19 pages, 8695 KiB  
Article
Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid
by Fatimah Rashid, Mustafa Albayati and Kalliopi Dodou
Cosmetics 2019, 6(4), 59; https://doi.org/10.3390/cosmetics6040059 - 1 Oct 2019
Cited by 4 | Viewed by 9004
Abstract
Hyaluronic acid (HA) is a natural polysaccharide with promising applications in modern cosmetic and nutricosmetic products due to its high-water affinity, which is essential for skin hydration, as well as its biocompatibility, biodegradability, non-toxicity, and non-immunogenic nature. In this study, we investigated and [...] Read more.
Hyaluronic acid (HA) is a natural polysaccharide with promising applications in modern cosmetic and nutricosmetic products due to its high-water affinity, which is essential for skin hydration, as well as its biocompatibility, biodegradability, non-toxicity, and non-immunogenic nature. In this study, we investigated and optimized the method of crosslinking for formulating novel HA hydrogel films. We used Pentaerythritol Tetra-acrylate (PT) as the cross-linking agent over a range of pH values and used different cross-linking methods (Ultraviolet (UV) radiation, microwaving, and oven heating). The efficacy of the cross-linking reaction was evaluated using swelling studies and Fourier transform infrared (FTIR) spectroscopy for the characterization of the xerogel HA-PT film formulations. We found that HA-PT cross-linked hydrogels are produced under alkaline conditions (pH 11) but not under neutral or acidic conditions. Cross-linked HA-PT xerogel films using UV-irradiation showed excessive swelling indicative of inadequate cross-linking. The oven and microwaving methods produced HA-PT films with high cross-linking density. FTIR data suggest formation of ester bond between the carbonyl of the HA and hydroxyl group of the PT acrylate group. Overall, the oven method was considered better and easier than UV-radiation/microwave methods because it is safer, user-friendly and eco-friendly, and can process larger batches. Full article
(This article belongs to the Special Issue Delivery Systems for Cosmetics)
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18 pages, 3750 KiB  
Article
Design of Prototype Formulations for In Vitro Dermal Delivery of the Natural Antioxidant Ferulic Acid Based on Ethosomal Colloidal Systems
by Cesar A. Londoño, John Rojas, Cristhian J. Yarce and Constain H. Salamanca
Cosmetics 2019, 6(1), 5; https://doi.org/10.3390/cosmetics6010005 - 19 Jan 2019
Cited by 14 | Viewed by 8331
Abstract
Ferulic acid (FA), a naturally occurring antioxidant, is currently used to prevent skin damage. However, FA is very unstable upon exposure to UV radiation and other factors, which decrease its shelf-life and effectiveness. Therefore, in this work, different prototypes of ethosomal FA vesicular [...] Read more.
Ferulic acid (FA), a naturally occurring antioxidant, is currently used to prevent skin damage. However, FA is very unstable upon exposure to UV radiation and other factors, which decrease its shelf-life and effectiveness. Therefore, in this work, different prototypes of ethosomal FA vesicular systems were designed and developed to provide protection against different environmental factors. A two-level fractional factorial design was employed using particle size, zeta potential (ZP), incorporation efficiency (EE), polydispersity index (PDI), and the existing relationship between length and width of vesicles or aspect ratio (AR) as response variables. The optimal formulation was characterized using differential scanning calorimetry (DSC), infrared analysis, UV-Vis absorption, in-vitro permeability, and thermal degradation studies. Depending on the processing conditions, the EE and particle size varied between 3 and 87% and 470 and 1208 nm, respectively. Membrane studies indicated that the free product released ~4.8% of the compound, whereas the encapsulated material released ~7.1%. Because of their enhanced permeability, ethosomes could be a promising alternative for the topical administration of antioxidants to reduce the oxidative damage caused by solar radiation. Full article
(This article belongs to the Special Issue Delivery Systems for Cosmetics)
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