Signaling Pathways in Liver Disease

Dear Colleagues,

Acute and chronic liver diseases are complex disorders driven by a variety of pathogenic signal transduction processes. These modulate the biology of parenchymal and non-parenchymal liver cells. Most important are cytokine and chemokine networks that orchestrate an inflammatory response leading to the recruitment and activation of distinct leukocyte subsets. Moreover, the different molecular mediators target specific signaling branches that lead to increased formation of extracellular matrix. Simultaneously, different classes of reactive species are formed, resulting in enhanced oxidative- and nitrosative stress, and liver cell damage. Persistent liver damage results in sequential progression from inflammation to fibrosis, cirrhosis, and hepatocellular carcinoma. Currently, there is a great deal of basic and clinical research ongoing, even at the single-cell level, to interrogate core molecular pathways underlying hepatic disease. We cordially invite you to contribute, in the form of original research articles, reviews, or shorter perspective articles, on all aspects related to the theme of “Signaling Pathways in Liver Disease”. Expert articles describing mechanistic, functional, cellular, biochemical, or general aspects of acute and chronic hepatic disease are highly welcome.

Prof. Dr. Ralf Weiskirchen
Dr. Ruchi Bansal
Prof. Dr. Gabriele Grassi
Prof. Dr. Leo A. Van Grunsven
Topic Editors