Liver Cancer Heterogeneity in the Era of Single-Cell and Spatial Multiomics
Special Issue Editors
Interests: NASH; immunmodulation; stromal cells; fibroblasts; progenitor cells; HCC; CCA
Special Issues, Collections and Topics in MDPI journals
Interests: liver disease; fibrosis; biomarker; cytokines; chemokines; translational medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Liver cancers, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), remain among the most lethal malignancies worldwide, driven in part by their profound heterogeneity at the genetic, cellular, and microenvironmental levels. Traditional bulk profiling approaches have failed to capture the complexity of tumor subtypes, immune landscapes, and stromal interactions that define patient outcomes and therapeutic responses.
This Special Issue aims to highlight recent advances in resolving liver cancer heterogeneity using high-dimensional technologies, including single-cell RNA sequencing, spatial transcriptomics, multiplexed imaging, and integrated multiomics approaches. We welcome original research papers and comprehensive reviews that explore cellular ecosystems of liver tumors and dissect intercellular signaling networks involved in immune evasion, fibrosis, and therapy resistance.
Prof. Dr. Veronika Lukacs-Kornek
Prof. Dr. Ralf Weiskirchen
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Livers is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- HCC
- CCA
- liver cancer
- scRNAseq
- cellular heterogeneity
- multiomics approaches
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
