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Children
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Pediatric Bone Disorders: Focus on Children's Bone Health
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Pediatric Bone Disorders: Focus on Children's Bone Health

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Orthopedics & Sports Medicine".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 812

Special Issue Editors

Dr. Maher A. Ghandour

E-Mail Website
Guest Editor
Department of Trauma and Reconstructive Surgery, RWTH University Hospital, 52074 Aachen, Germany
Interests: pediatric orthopedic surgery; spine surgery; osteoarthritis; bone pathology; fractures in children; limb deformities
Special Issues, Collections and Topics in MDPI journals
Dr. Axel A. Horsch

E-Mail Website
Guest Editor
Department of Orthopedics and Trauma Surgery, Heidelberg University Hospital, Heidelberg, Germany
Interests: pediatric orthopedic surgery; limbs deformities; osteoarthritis; orthopedic tumor and sarkoma surgery; foot and ankle surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Miguel Pishnamaz

E-Mail Website
Guest Editor
Department of Trauma and Reconstructive Surgery, RWTH University Hospital, 52074 Aachen, Germany
Interests: spine surgery; orthopedic surgery

Special Issue Information

Dear Colleagues,

Pediatric bone health is a cornerstone of overall childhood development and growth, yet it remains a complex field due to the wide spectrum of bone disorders seen in children. These disorders range from congenital and genetic conditions, such as osteogenesis imperfecta and rickets, to acquired issues like metabolic bone diseases, and infection-related osteomyelitis. Advances in diagnostic imaging, molecular genetics, and surgical interventions have significantly improved the understanding and treatment of pediatric bone diseases. This Special Issue, "Pediatric Bone Disorders: Focus on Children's Bone Health", aims to bring together cutting-edge research and clinical advancements that explore the etiology, diagnosis, treatment, and rehabilitation of pediatric bone disorders. Contributions focusing on innovative approaches to diagnosis, therapeutic strategies, and long-term care to improve quality of life in children are especially encouraged. We invite experts from diverse disciplines to share their work, fostering collaboration and improving the management of pediatric bone disorders.

Dr. Maher A. Ghandour
Dr. Axel A. Horsch
Dr. Miguel Pishnamaz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric bone disorders
  • osteogenesis imperfecta
  • rickets
  • orthopedic interventions
  • metabolic bone diseases
  • bone pathology

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Published Papers (1 paper)

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Research

11 pages, 1050 KiB  
Article
A Novel Method to Study Hip Growth and Development in Children with Cerebral Palsy
by Luiz Carlos Almeida da Silva, Yusuke Hori, Burak Kaymaz, Jason J. Howard, Arianna Trionfo, Michael Wade Shrader and Freeman Miller
Children 2025, 12(3), 367; https://doi.org/10.3390/children12030367 - 15 Mar 2025
Viewed by 529
Abstract
Background: Knowledge of the relative contributions to different growth areas in the proximal femur and acetabulum is limited due to the complex anatomy and lack of growth markers in children. There is increasing interest in using guided growth to improve hip joint stability [...] Read more.
Background: Knowledge of the relative contributions to different growth areas in the proximal femur and acetabulum is limited due to the complex anatomy and lack of growth markers in children. There is increasing interest in using guided growth to improve hip joint stability and decrease dysplasia in children with neurological disability. Some children with cerebral palsy (CP) are treated with bisphosphonates for bone insufficiency, which leaves a dense growth arrest band in the bone at the time of treatment. The aim of this study was to develop a novel approach to understand the growth and maturation impact on hip development in children with CP using this growth arrest band. Methods: Pelvic radiographs of children with CP Gross Motor Function Classification System (GMFCS) level IV/V treated with bisphosphonate were analyzed. We measured neck–shaft angle (NSA), head–shaft angle (HSA), and migration percentage (MP) based on pamidronate bands (PamMP), NSA based on pamidronate bands (PamNSA), and HSA based on pamidronate bands (PamHSA). These measurements were compared using t-test. Results: Seven children (two GMFCS IV and five GMFCS V) were included. The mean age of the radiographic assessment was 11.4 ± 1.3 (range, 8.6–12.5) years, mean MP 22 ± 7% (range, 13–39%), PamMP 33 ± 7% (range, 18–46%), NSA 151 ± 7° (range, 140–161°), PamNSA 153 ± 4° (range, 142–163°), HSA 164 ± 12° (range, 142–175°), and PamHSA 169 ± 8° (range, 154–175°). MP decreased by 10.5% compared with PamMP (p < 0.001). NSA compared with PamNSA (p = 0.117) and HSA compared with PamHSA (p = 0.325) were not statistically different. Conclusions: This novel assessment method demonstrates that ossification of the lateral acetabulum and femoral head in children with CP GMFCS IV/V from age 8 to 12 years undergoes a mean decrease of 10% MP. A decrease of 10% MP after proximal femoral-guided growth has been reported as a positive outcome. However, based on the current measurements, this may be due to normal development. HSA and NSA remained unchanged. Full article
(This article belongs to the Special Issue Pediatric Bone Disorders: Focus on Children's Bone Health)
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