The Increasingly Fascinating World of Interleukins

Dear Colleagues,

The number of interleukin types has increased over the years, finally reaching over 40. Many interleukins play a pro-inflammatory role, but some have anti-inflammatory properties. In addition, many interleukins are produced by immune system cells, but some are also produced by non-immune-system cells. It is also interesting to note that several interleukin subfamilies share intracellular signaling. The complexity and sophistication of this system has fascinated many basic and clinical researchers. There are successful examples of bridging basic research to clinical practice; antibody drugs against interleukins and their receptors are used for treatment. In particular, expectations are now rising for the fulfilment of unmet medical needs. Regulating interleukins to control disease was a great achievement, but it is only one success story. It is now becoming clear that interleukins are involved in biological responses before the onset of disease, and that they are involved not only in intercellular networks but also in interorgan networks.

In this Topical Collection of Cells, we seek contributions either in the form of original research articles, reviews, or shorter perspective articles on all aspects related to the subject of “The Increasingly Fascinating World of Interleukins”. We would like to see the fascinating world of interleukins explained by leading experts in their respective fields of research. Papers that demonstrate mechanisms at the cellular or molecular level, in vitro or in vivo, and functional insights in basic or clinical research are welcome.

Dr. Yasu-Taka Azuma
Collection Editor

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