Molecular and Cellular Mechanisms of Ischemia-Reperfusion Injury and Protective Strategies
A topical collection in Cells (ISSN 2073-4409). This collection belongs to the section "Cells of the Cardiovascular System".
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2. CIBER de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain
Interests: ischemia-reperfusion injury; myocardial infarction; gap junctions; connexin 43; mitochondrial; succinate dehydrogenase; heart failure
2. CIBER de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain
Interests: mitochondria; calcium; AGEs; aging; ischemia/reperfusion injury; heart failure
2. CIBER de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain
Interests: myocardial ischemia/reperfusion injury; heart failure; calpains; fibrosis; hypertrophy; nitric oxide; guanylate cyclase
Topical Collection Information
Dear Colleagues,
Ischemic disorders are a leading cause of death and disability worldwide, and affect multiple organs, including the heart, brain, kidney and the gut, among others. Several conditions, such as acute coronary syndrome, sepsis, thromboembolism, organ transplantation or limb injury, may produce tissue hypoperfusion and ischemia. The treatment of choice for patients suffering from tissue ischemia is the immediate restoration of blood flow. However, and despite the correct and rapid application of blood flow restoration techniques, reperfusion protocols do not prevent the occurrence of extensive cell death and tissue necrosis in a significant fraction of patients. This is, in part, due to the fact that blood flow restoration can itself cause a paradoxical exacerbation of injury, a phenomenon termed reperfusion injury. Importantly, reperfusion injury can be prevented by treatments applied at the onset of reflow, which presents a promising therapeutic opportunity. However, the protective effect of most of these treatments has not been confirmed in clinical trials. Therefore, it is essential to increase our knowledge on the pathophysiology of ischemia-reperfusion injury, to be able to propose new therapeutic approaches specifically addressed to mitigate it.
This Topical Collection aims to summarize the current knowledge on the molecular and cellular mechanisms of ischemia-reperfusion injury, to explore tissue specific differences, and to identify potential therapeutic strategies capable of reducing cell death and dysfunction that could, eventually, be applied to patients.
We look forward to your contributions.
Dr. Antonio Rodríguez-Sinovas
Dr. Marisol Ruiz-Meana
Dr. Javier Inserte
Collection Editors
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Keywords
- reperfusion injury
- ischemia
- infarct
- stroke
- conditioning
- cardioprotection
- mitochondria
- heart
- kidney
- brain
- gut
- limb