Allergy, Asthma and Clinical Immunology

A topical collection in Cells (ISSN 2073-4409). This collection belongs to the section "Cellular Immunology".

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Editors


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Collection Editor
Institute of Clinical Immunotherapy and Advanced Biological Treatments, Pescara, Italy
Interests: cellular and clinical immunology; allergy
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Collection Editor
Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy
Interests: mediators of inflammation, cytokines, and biomarkers of oxidative stress; immunosenescence; immunogenetics; epigenetics; application of machine learning and deep learning in various fields of medicine
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Collection Editor
Allergy and Clinical Immunology, Medicine and Surgery Department, University of Parma, Parma, Italy
Interests: eosinophil gastrointestinal diseases (EoE); food allergy; immunotherapy; asthma; allergic respiratory diseases

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Collection Editor

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Collection Editor
Unit of Internal Medicine “Guido Baccelli”, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro, 70124 Bari, Italy
Interests: multiple myeloma; microenvironment; oncology; angiogenesis; hematology
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Topical Collection Information

Dear Colleagues,

Immunology has seen tremendous scientific advancements in recent decades. The definition of the cellular and molecular mechanisms of innate and adaptive immunity has led to better comprehension of health status and illness. There is a synergy between the adaptive immune system and its innate counterpart, and their defects can provoke inappropriate inflammation, autoimmunity, immunodeficiency, and hypersensitivity reactions. The identification of the cellular and molecular mechanisms at the base of their immune mechanism allowed a precise endotyping of many diseases, with the development of specific immunotherapy.

This Topical Collection is a cooperation between the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC) and Cells, dedicated to research that can enhance our understanding of the molecular and cellular aspects of allergic and immune diseases. It encompasses all of the cellular and molecular aspects of the genetics, pathogenesis, clinical, pathology, diagnosis, and treatment of allergic as well as immunologic disease.

It is especially dedicated to the following areas and other related topics: T cell and B cell functions, regulatory T cells, natural killer cells, antigen-presenting cells, mast cells and eosinophils, and complement abnormalities. Particular emphasis will be devoted to asthma, rhinoconjunctivitis and rhinosinusitis, atopic dermatitis, urticaria and angioedema, venom hypersensitivity, anaphylaxis and food allergy, immune deficiency, autoimmunity, and immunosenescence. Contributions on the mechanisms of the basis of the effectiveness of immunotherapy, immune modulators, and biologics will be particularly appreciated.

Prof. Dr. Mario Di Gioacchino
Prof. Dr. Sebastiano Gangemi
Prof. Dr. Erminia Ridolo
Dr. Giovanni Paoletti
Dr. Antonio G. Solimando
Collection Editors

Manuscript Submission Information

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Keywords

  • T cells and B cells
  • regulatory T cells
  • NK cells
  • antigen-presenting cells
  • mast cells
  • eosinophils
  • complement
  • inflammation
  • cytokines
  • immunosenescence
  • immuno-oncology

Diseases:

  • anaphylaxis
    hypereosinophilic syndrome
  • asthma
  • rhinoconjunctivitis
  • rhinosinusitis
  • atopic dermatitis
  • urticaria
  • angioedema
  • food allergy
  • innate and acquired immunedeficiency
  • systemic and organ-specific autoimmune diseases
Treatments:
  • immunotherapy
  • biologics

Published Papers (1 paper)

2024

28 pages, 2757 KiB  
Review
Managing Patients with Hypereosinophilic Syndrome: A Statement from the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC)
by Marco Caminati, Luisa Brussino, Matilde Carlucci, Palma Carlucci, Lucia Federica Carpagnano, Cristiano Caruso, Lorenzo Cosmi, Simona D’Amore, Stefano Del Giacco, Aikaterini Detoraki, Mario Di Gioacchino, Andrea Matucci, Ilaria Mormile, Francescopaolo Granata, Gabriella Guarnieri, Mauro Krampera, Matteo Maule, Eustachio Nettis, Stefania Nicola, Silvia Noviello, Fabrizio Pane, Cristina Papayannidis, Paola Parronchi, Girolamo Pelaia, Erminia Ridolo, Francesca Wanda Rossi, Gianenrico Senna, Massimo Triggiani, Angelo Vacca, Emanuele Vivarelli, Alessandra Vultaggio and Amato de Paulisadd Show full author list remove Hide full author list
Cells 2024, 13(14), 1180; https://doi.org/10.3390/cells13141180 - 11 Jul 2024
Cited by 1 | Viewed by 2184
Abstract
Hypereosinophilic syndrome (HES) encompasses a heterogeneous and complex group of different subtypes within the wider group of hypereosinophilic disorders. Despite increasing research interest, several unmet needs in terms of disease identification, pathobiology, phenotyping, and personalized treatment remain to be addressed. Also, the prospective [...] Read more.
Hypereosinophilic syndrome (HES) encompasses a heterogeneous and complex group of different subtypes within the wider group of hypereosinophilic disorders. Despite increasing research interest, several unmet needs in terms of disease identification, pathobiology, phenotyping, and personalized treatment remain to be addressed. Also, the prospective burden of non-malignant HES and, more in general, HE disorders is currently unknown. On a practical note, shortening the diagnostic delay and the time to an appropriate treatment approach probably represents the most urgent issue, even in light of the great impact of HES on the quality of life of affected patients. The present document represents the first action that the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC) has finalized within a wider project aiming to establish a collaborative national network on HES (InHES—Italian Network on HES) for patients and physicians. The first step of the project could not but focus on defining a common language as well as sharing with all of the medical community an update on the most recent advances in the field. In fact, the existing literature has been carefully reviewed in order to critically integrate the different views on the topic and derive practical recommendations on disease identification and treatment approaches. Full article
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