Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Brain Function and Structure: Mapping Complexity in Neuronal Cells submission deadline 25 May 2026 | Viewed by 43 | Submission Open
Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience
Human DNA Replication/Repair Factors submission deadline 25 May 2026 | Viewed by 21 | Submission Open
Keywords: DNA replication; replisome; DNA polymerase; helicase; replication fork; DNA repair; replication stress; DNA damage response; homologous recombination; replication-coupled DNA repair
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies submission deadline 29 May 2026 | Viewed by 238 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Advanced Research in Neurogenesis and Neuroinflammation
edited by
submission deadline 30 May 2026 | 2 articles | Viewed by 1932 | Submission Open
Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions
(This special issue belongs to the Section Cellular Neuroscience)
Therapeutic Targeting of Myeloid Cells in Tumor
edited by Mirko Farina and
submission deadline 30 May 2026 | Viewed by 47 | Submission Open
Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development
Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance
edited by and Kleiton Silva
submission deadline 30 May 2026 | Viewed by 39 | Submission Open
Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders
(This special issue belongs to the Section Autophagy)
Genome Editing in Biomedicine
edited by
submission deadline 30 May 2026 | Submission Open
Keywords: genome manipulation; CRISPR/Cas systems; base editing and prime editing; cellular models (organoids/stem cells); stem cell editing; animal models; genetically engineered mouse models (GEMMs); translational research; cell therapy; editing efficiency; virus-like particles (VLPs)
(This special issue belongs to the Section Cell and Gene Therapy)
Protein-Protein Interaction in Health and Disease submission deadline 30 May 2026 | Submission Open
Keywords: protein– protein interactions; mass spectrometry; cross-linking; disease mechanisms; structural biology; proteomics; therapeutic targets; protein complexes
(This special issue belongs to the Section Cell Signaling)
Perinatal Brain Injury—from Pathophysiology to Therapy
edited by Cora H.A. Nijboer, and
submission deadline 31 May 2026 | 9 articles | Viewed by 20109 | Submission Open
Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells
(This special issue belongs to the Section Cellular Neuroscience)
Proteomic Applications in Ageing and Neurodegenerative Conditions submission deadline 31 May 2026 | 4 articles | Viewed by 18965 | Submission Open
(This special issue belongs to the Section Cell Methods)
3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures submission deadline 31 May 2026 | 6 articles | Viewed by 13997 | Submission Open
Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling
(This special issue belongs to the Section Cell Methods)
Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics—Second Edition
edited by
submission deadline 31 May 2026 | 4 articles | Viewed by 12249 | Submission Open
Keywords: spine; intervertebral disc; biomaterial; stem cell; gene therapy
(This special issue belongs to the Section Cellular Pathology)
Cilia-Based New Discoveries: Ciliogenesis, Function, and Human Diseases submission deadline 31 May 2026 | 2 articles | Viewed by 5466 | Submission Open
Keywords: primary cilium; human disease; cell signaling; mTOR; Hedgehog; WNT; PDGFRalpha
Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 5245 | Submission Open
Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression
(This special issue belongs to the Section Stem Cells)
Glial Cells: Physiological and Pathological Perspective
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 4013 | Submission Open
Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies
(This special issue belongs to the Section Cellular Neuroscience)
Natural Killer (NK) Cells in Immunity: Limitations and Potential
edited by Rehan Mujeeb Faridi
submission deadline 31 May 2026 | 2 articles | Viewed by 3380 | Submission Open
Keywords: natural killer cells; adaptive NK cells; infection
(This special issue belongs to the Section Cellular Immunology)
Adipose-Derived Stem Cells for Tissue Regeneration submission deadline 31 May 2026 | 2 articles | Viewed by 3051 | Submission Open
Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies
(This special issue belongs to the Section Tissues and Organs)
Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 2989 | Submission Open
Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine
(This special issue belongs to the Section Stem Cells)
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function
edited by and Federica Scalia
submission deadline 31 May 2026 | 1 articles | Viewed by 1696 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Non-Coding RNAs as Regulators of Cellular Function and Disease
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 1488 | Submission Open
Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms
Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity
edited by Jiabei Lin
submission deadline 31 May 2026 | 1 articles | Viewed by 768 | Submission Open
Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer
G Protein-Coupled Receptors and Diseases
edited by
submission deadline 31 May 2026 | Viewed by 630 | Submission Open
Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation
Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)
edited by Robert Sharp and
submission deadline 31 May 2026 | Viewed by 398 | Submission Open
Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology
(This special issue belongs to the Section Cellular Pathology)
Role of Lysosomes in Mediating Cancer Drug Resistance
edited by
submission deadline 31 May 2026 | Viewed by 203 | Submission Open
Keywords: drug resistance; autophagic cell death; lysosomal-mediated cell death; autophagy; apoptosis; lysosomal exocytosis; lysosomal sequestration; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics submission deadline 31 May 2026 | Viewed by 173 | Submission Open
Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets
Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 31 May 2026 | Viewed by 167 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Basis of Brain Tumor
edited by , Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak
submission deadline 31 May 2026 | Viewed by 165 | Submission Open
Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research
(This special issue belongs to the Section Cellular Pathology)
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 31 May 2026 | Viewed by 160 | Submission Open
Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease
(This special issue belongs to the Section Cellular Neuroscience)
Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis
edited by and Jianzhong Shen
submission deadline 31 May 2026 | Viewed by 148 | Submission Open
Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling
Development and Characterization of Innovative In Vitro Models
edited by Fengyan Deng and Chongbei Zhao
submission deadline 31 May 2026 | Viewed by 139 | Submission Open
Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 31 May 2026 | Viewed by 115 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis
edited by
submission deadline 31 May 2026 | Viewed by 108 | Submission Open
Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune– stromal crosstalk; multi-omics
Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression
edited by and
submission deadline 31 May 2026 | Viewed by 108 | Submission Open
Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition
(This special issue belongs to the Section Cells of the Cardiovascular System)
Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation
edited by and Osvaldo Bogado Pascottini
submission deadline 31 May 2026 | Viewed by 107 | Submission Open
Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling
Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate submission deadline 31 May 2026 | Viewed by 93 | Submission Open
Keywords: mitochondria; stem cells; cell fate; organogenesis; immunometabolism
Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms submission deadline 31 May 2026 | Viewed by 92 | Submission Open
Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration
Skeletal Muscle Aging and Regeneration: Mitochondrial Health, Molecular Signaling, and Therapeutic Interventions
edited by
submission deadline 31 May 2026 | Viewed by 83 | Submission Open
Keywords: aging; skeletal muscle; regeneration; satellite cells; muscle stem cells; muscle wasting; mitochondria; fibro-adipogenic progenitor cells; repair
DNA Damage and Repair in Targeted Cancer Therapy
edited by Mohd Saleem Dar, Sajad Ahmad Bhat and
submission deadline 31 May 2026 | Viewed by 74 | Submission Open
Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine
Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets
edited by Shridhar Sanghvi, and
submission deadline 31 May 2026 | Viewed by 56 | Submission Open
Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology
Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects submission deadline 31 May 2026 | Viewed by 55 | Submission Open
Keywords: neurodevelopmental disorders; neuronal connectivity; precocious therapies; synaptic plasticity; neurogenesis; glial function
(This special issue belongs to the Section Cellular Neuroscience)
Epigenetic and Cellular Regulation in Hematologic Disorders
edited by
submission deadline 31 May 2026 | Viewed by 54 | Submission Open
Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding
B Cells in Action: Interaction Dynamics and Functional Decisions
edited by Michael L. Atchison and
submission deadline 31 May 2026 | Viewed by 52 | Submission Open
Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response
(This special issue belongs to the Section Cellular Immunology)
Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches
edited by Tomaž Büdefeld and
submission deadline 31 May 2026 | Viewed by 47 | Submission Open
Keywords: endometrial cancer; genetic mutation; epigenetics; cell signaling; TIME; metastasis; biomarker; therapy; drug delivery; risk factor
Decoding Heart Failure: From Mechanisms to Treatment
edited by and Dirk L. Brutsaert
submission deadline 31 May 2026 | Viewed by 42 | Submission Open
Keywords: heart failure; pathological process; molecular mechanisms; cellular mechanisms; genetic mechanisms; therapeutic target
Cellular and Molecular Mechanisms of Heart Development
edited by Jun K. Takeuchi
submission deadline 31 May 2026 | Viewed by 41 | Submission Open
Keywords: heart development; cardiovascular; epigenetics; cell fate; differentiation; cardiac growth; cardiac morphogenesis; heart regeneration; cardiac organoid
Cellular Responses to Heavy Metals: From Intestinal Uptake to Disease submission deadline 31 May 2026 | Viewed by 36 | Submission Open
Keywords: cadmium (Cd) bioavailability; heavy metal intestinal uptake; heavy metal-induced cardiotoxicity; heavy metal-induced neurotoxicity; heavy metal-induced osteotoxicity; heavy metals and malignancies
Cellular and Molecular Pathways in Immune Tolerance and Autoimmune Regulation
edited by Md Jahangir Alam
submission deadline 31 May 2026 | Viewed by 28 | Submission Open
Keywords: immune tolerance; autoimmune regulation; immune homeostasis; regulatory T cells; regulatory B cells; cytokine networks; molecular mechanisms; therapeutic strategies
(This special issue belongs to the Section Cellular Immunology)
Stem Cell-Based Strategies for Cardiac Tissue Engineering and Regeneration
edited by Munira Xaymardan and
submission deadline 31 May 2026 | Viewed by 27 | Submission Open
Keywords: cardiac tissue engineering; stem cells; cardiomyocytes; cardiac organoids; engineered heart tissues; biomaterials; scaffolds; gene therapy; RNA reprogramming; cardiac fibrosis; cardiac regeneration; myocardial repair; translational studies
(This special issue belongs to the Section Stem Cells)
Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders submission deadline 31 May 2026 | Viewed by 25 | Submission Open
Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast
Cancer and Vessels: Insights at the Cellular and Molecular Levels
edited by Francesco Pezzella and Tom Donnem
submission deadline 31 May 2026 | Viewed by 13 | Submission Open
Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis
(This special issue belongs to the Section Cellular Pathology)
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