Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Drivers of Oncogenesis and Tumor Evolution: Mechanisms and Cellular Pathways submission deadline 29 Jan 2027 | Viewed by 267 | Submission Open
Keywords: oncogenesis; cancer progression; cancer biology; tumor immunology; tumor microenvironment; metastasis; angiogenesis; metabolic reprogramming; therapy resistance
State of the Art and Future Prospects in Central Nervous System Cancer Therapeutics
edited by Kristen Batich
submission deadline 29 Jan 2027 | Viewed by 260 | Submission Open
Keywords: neuro-oncology; central nervous system; immunotherapy; antigen presentation; cancer vaccines
(This special issue belongs to the Section Cellular Neuroscience)
Gene Regulation in Epithelial Cells
edited by Jennifer Zhang
submission deadline 29 Jan 2027 | Viewed by 231 | Submission Open
Keywords: epithelial cells; gene regulation; epigenetic regulation; epithelium–immune crosstalk; epithelium–microbial interaction
(This special issue belongs to the Section Cell and Gene Therapy)
Advances in 3D Biology for Translational Medicine: Promises and Challenges
edited by David C. Hay, and
submission deadline 30 Jan 2027 | Viewed by 159 | Submission Open
Keywords: tissue engineering; spheroids; organoids; informatics; in vitro modelling; phenotyping; in vivo transplant
New Insights into Plant Bioactive Compounds submission deadline 31 Jan 2027 | 2 articles | Viewed by 679 | Submission Open
Keywords: abiotic and biotic stresses; defense mechanism; signaling pathway; secondary metabolites; biostimulants; nanotechnology; bioactivity; reactive oxygen species
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Retinal Diseases: Cellular and Molecular Mechanisms
edited by and
submission deadline 31 Jan 2027 | Viewed by 294 | Submission Open
Keywords: retinal disease; age-related macular degeneration; glaucoma; genetic risk factors; WES; WGS; GWAS; functional analysis of mutations; retinal cell signaling; pathogenic mechanisms
(This special issue belongs to the Section Cellular Pathology)
Therapeutic Advances in Leukemia: Unraveling Molecular and Immune Mechanisms
edited by , Justyna Woś and
submission deadline 31 Jan 2027 | Viewed by 244 | Submission Open
Keywords: molecular diagnostics; targeted therapy; immunotherapy; genetic mutations; leukemia pathogenesis; leukemia treatment; epigenetic regulation; cancer biomarkers; hematologic malignancies
(This special issue belongs to the Section Cellular Immunology)
Stem Cell Reprogramming and Cellular Differentiation
edited by
submission deadline 31 Jan 2027 | Viewed by 133 | Submission Open
Keywords: stem cell differentiating stage factors; cell reprogramming; cell differentiation; stem cells; epigenetic regulation; cellular plasticity
(This special issue belongs to the Section Stem Cells)
Cellular and Functional Regulation of Skeletal Muscle Performance and Dysfunction
edited by and Maha Dahawi
submission deadline 31 Jan 2027 | Viewed by 71 | Submission Open
Keywords: muscle wasting and dysfunction; chronic and critical illness; patients physical performance
(This special issue belongs to the Section Tissues and Organs)
Neuroinflammation and Oxidative Stress in Retinal Neurodegeneration
edited by Hanhan Liu, and Pietro Bertelli
submission deadline 31 Jan 2027 | Viewed by 41 | Submission Open
Keywords: retinal degeneration; oxidative stress; neuroinflammation; mitochondrial dysfunction; gliosis
(This special issue belongs to the Section Cellular Neuroscience)
Protein Modification and Signal Transduction in Cells
edited by Shawn Shun-Cheng Li
submission deadline 31 Jan 2027 | Viewed by 41 | Submission Open
Keywords: post-translational modification (PTM); signal transduction; phosphorylation; acetylation; methylation; ubiquitination; SUMOylation; glycosylation; cancer; drug targets; immunotherapy
(This special issue belongs to the Section Cell Signaling)
Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease—2nd Edition
edited by , Leila Gobejishvili, and Michy P. Kelly
submission deadline 31 Jan 2027 | Viewed by 40 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
Cardiac Fibroblasts, Fibrosis, and Cardiac Remodeling
edited by Alexander Widiapradja
submission deadline 31 Jan 2027 | Viewed by 27 | Submission Open
Keywords: fibroblasts; remodeling; fibrosis; extra cellular matrix; cardiac fibrosis; cardiac remodeling
(This special issue belongs to the Section Cells of the Cardiovascular System)
Stem Cells in Congenital Heart Disease: Novel Approaches and Regenerative Strategies
edited by , and Wei Shi
submission deadline 1 Feb 2027 | Viewed by 344 | Submission Open
Keywords: stem cell; congenital heart defect; iPSC; maturation; regeneration; cardiac arrhythmia; heart failure
(This special issue belongs to the Section Stem Cells)
Inflammation in Target Organs—Second Edition
edited by and Sarah Weksler-Zangen
submission deadline 1 Feb 2027 | Viewed by 336 | Submission Open
Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain
(This special issue belongs to the Section Cellular Immunology)
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring the Therapeutic Strategies
edited by , Elena Dozio and Lucia la Sala
submission deadline 1 Feb 2027 | Viewed by 96 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration—Second Edition
edited by Aurora Almadori
submission deadline 1 Feb 2027 | Viewed by 86 | Submission Open
Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; aging; immune response; inflammation; scarring
(This special issue belongs to the Section Stem Cells)
Pathogenesis and Novel Therapies for Epithelial Carcinoma
edited by Jung Wook Park
submission deadline 2 Feb 2027 | Viewed by 26 | Submission Open
Keywords: transformation; malignant; oncogene; tumor suppressor; molecular mechanisms; epigenetic; metabolic; immune; biomarkers; personalized medicine; primary cells; small-molecule inhibitor
(This special issue belongs to the Section Cellular Pathology)
NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets
edited by Gaetano Spinelli and
submission deadline 3 Feb 2027 | Viewed by 437 | Submission Open
Keywords: NF-κB signaling; inflammation; canonical and non-canonical pathways; immune regulation; post-translational modifications; signal transduction; inflammatory diseases; autoimmune disorders; cancer; tumor microenvironment; oncogenesis; metabolic diseases; neuroinflammation; therapeutic targets; drug development
Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer submission deadline 10 Feb 2027 | 5 articles | Viewed by 8187 | Submission Open
Keywords: tumor microenvironment; epithelial–mesenchymal transition (EMT); tumor–stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology
The Power of Small Molecules in Cancer
edited by
submission deadline 10 Feb 2027 | Viewed by 64 | Submission Open
Keywords: small molecule; cancer therapy; kinase inhibitors
(This special issue belongs to the Section Cell and Gene Therapy)
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 15 Feb 2027 | 2 articles | Viewed by 3208 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
The Role of Mitochondria in Health, Disease, and Ageing submission deadline 15 Feb 2027 | 2 articles | Viewed by 2068 | Submission Open
Keywords: mitochondrial dysfunction; metabolism; mitochondrial genetics; aging and senescence; bioenergetics; mitophagy; neurodegeneration; cardiomyopathy; metabolic syndrome; ocular diseases
(This special issue belongs to the Section Mitochondria)
NAMs (New Approach Methodologies) and Neural Stem Cells
edited by Tongguang Wang
submission deadline 15 Feb 2027 | 2 articles | Viewed by 1703 | Submission Open
Keywords: neural stem cells (NSCs); brain organoids; neurodevelopmental disorders; human pluripotent stem cells (hPSCs); translational neuroscience; new approach methodologies
(This special issue belongs to the Section Stem Cells)
Role of Macrophages in Tissue Repair
edited by
submission deadline 15 Feb 2027 | 1 articles | Viewed by 723 | Submission Open
Keywords: macrophages; inflammation; tissue repair; phagocytosis
(This special issue belongs to the Section Tissues and Organs)
Organoids as Next-Generation Preclinical Models of Disease Progression
edited by Ralf Weiskirchen, Anjali A. J. Roeth and
submission deadline 15 Feb 2027 | 1 articles | Viewed by 473 | Submission Open
Keywords: patient-derived organoids; longitudinal disease modelling; neurodegeneration progression; drug resistance; precision medicine; chronic inflammation; tumor evaluation
Harnessing the Immune System: Emerging Therapeutic Strategies in Cancer
edited by Kishan Shamjibhai Italiya
submission deadline 15 Feb 2027 | Viewed by 258 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; adoptive cell therapy; cancer vaccines; T cell therapy; immuno-oncology; tumor immune evasion; immune modulation; antitumor immunity
(This special issue belongs to the Section Cellular Immunology)
Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease
edited by and Akshat Sharma
submission deadline 19 Feb 2027 | 2 articles | Viewed by 5955 | Submission Open
Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms
(This special issue belongs to the Section Cellular Pathology)
Cellular Signaling and Metabolic Adaptations in the Tumor Microenvironment
edited by Shashi Anand
submission deadline 19 Feb 2027 | 1 articles | Viewed by 926 | Submission Open
Keywords: cancer metabolic plasticity; tumor microenvironment; metabolic vulnerabilities; oncogenic signaling pathways; hypoxia and nutrient stress; therapeutic resistance
(This special issue belongs to the Section Cellular Metabolism)
Pathogenic Angiogenic Mechanisms in Alzheimer's Disease submission deadline 19 Feb 2027 | Viewed by 19 | Submission Open
Keywords: pathological angiogenesis; endothelial dysfunction; blood–brain barrier breakdown; cerebral hypoperfusion; Alzheimer’s disease pathogenesis
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in Vitamin D and K in Cancer submission deadline 25 Feb 2027 | Viewed by 367 | Submission Open
Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance
Ion Channels and Transporters—Structure and Function
edited by Tiziano Mazza, Jonathan Paul Lambert and
submission deadline 25 Feb 2027 | Viewed by 84 | Submission Open
Keywords: ion channels; membrane transporters; SLC; ABC; structure-function relationship; Cryo-EM; X-ray crystallography; molecular mechanism; computational biology
Cancer and Immune System Interactions submission deadline 26 Feb 2027 | 4 articles | Viewed by 4044 | Submission Open
Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor–immune interactions; immune checkpoint regulation; translational oncology
(This special issue belongs to the Section Cell Microenvironment)
Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts
edited by Simonetta Masieri and
submission deadline 26 Feb 2027 | 1 articles | Viewed by 3276 | Submission Open
Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins
(This special issue belongs to the Section Tissues and Organs)
A New Frontier for Cancer Diagnosis and Therapy submission deadline 26 Feb 2027 | 2 articles | Viewed by 2932 | Submission Open
Keywords: cancer diagnosis; precision oncology; liquid biopsy; molecular biomarkers; immunotherapy; targeted therapy; nanomedicine; multi-omics; artificial intelligence; tumor heterogeneity
(This special issue belongs to the Section Cellular Immunology)
Mitochondrial Dynamics in Health and Disease Metabolism: Mechanisms and Functional Consequences
edited by
submission deadline 26 Feb 2027 | 3 articles | Viewed by 2578 | Submission Open
Keywords: mitochondrial fission; mitochondrial fusion; mitophagy; mitochondrial transport; mitochondrial transfer; mitochondrial diseases
(This special issue belongs to the Section Mitochondria)
Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk
edited by Aparna Renigunta and
submission deadline 26 Feb 2027 | 2 articles | Viewed by 2248 | Submission Open
Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation
Application of Stem Cells and Cellular Engineering in Musculoskeletal Tissue Regeneration submission deadline 26 Feb 2027 | 2 articles | Viewed by 1789 | Submission Open
Keywords: mesenchymal stem cells (MSCs); tissue specific progenitors; cellular engineering; musculoskeletal tissue regeneration; tissue engineering; biomaterials; 3D culture systems; mechanobiology; extracellular vesicles; translational regenerative medicine
(This special issue belongs to the Section Stem Cells)
Cellular and Molecular Mechanisms in Reproductive Biology and Fertility
edited by and Antonio Malvasi
submission deadline 26 Feb 2027 | 1 articles | Viewed by 1291 | Submission Open
Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo–maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation
(This special issue belongs to the Section Reproductive Cells and Development)
Molecular and Cellular Mechanisms of Pheochromocytoma and Paraganglioma
edited by and
submission deadline 26 Feb 2027 | Viewed by 275 | Submission Open
Keywords: pheochromocytoma; paraganglioma; tumor biology; molecular mechanisms; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Genomics and Cellular Mechanisms in Ovarian Cancer
edited by Hao Huang
submission deadline 28 Feb 2027 | 3 articles | Viewed by 5031 | Submission Open
Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Tissues and Organs)
Molecular Signal Transduction in Cancer submission deadline 28 Feb 2027 | Viewed by 200 | Submission Open
Keywords: molecular signal transduction; tumor microenvironment; tumor suppressor; kinase signaling; transcriptional and epigenetic regulation; immune signaling; cancer cell communication
(This special issue belongs to the Section Cell Signaling)
Corneal Biology and Pathophysiology: From Homeostasis to Disease
edited by , Anil Tiwari and Gary (Hin-Fai) Yam
submission deadline 28 Feb 2027 | Viewed by 58 | Submission Open
Keywords: corneal regeneration; corneal tissue homeostasis; corneal pathophysiology; corneal therapeutics
(This special issue belongs to the Section Cellular Pathology)
The Role of Oxidative Stress in Cardiovascular Diseases—3rd Edition
edited by and
submission deadline 28 Feb 2027 | Viewed by 49 | Submission Open
Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species
(This special issue belongs to the Section Cells of the Cardiovascular System)
Molecular Biomarkers in Tumors: Prognosis and Mechanisms
edited by
submission deadline 28 Feb 2027 | Viewed by 36 | Submission Open
Keywords: molecular biomarkers; tumor prognosis; tumor microenvironment; genomic alterations; therapeutic resistance; liquid biopsy; extracellular vesicles; multi-omics
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Vascular-Related Diseases—Second Edition
edited by and
submission deadline 28 Feb 2027 | Viewed by 17 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system; drug delivery via vascular system
(This special issue belongs to the Section Cellular Pathology)
Novel Insights into Amyotrophic Lateral Sclerosis (ALS)
edited by Zane Zeier
submission deadline 1 Mar 2027 | Viewed by 257 | Submission Open
Keywords: TDP-43 proteinopathy; protein aggregation; RNA metabolism; DNA damage; cryptic splicing; nucleocytoplasmic transport; liquid–liquid phase separation; mitochondrial dysfunction; mitophagy; neuroinflammation; microglial activation; astrogliosis; glutamate excitotoxicity; multi-omics; integrative omics
Cellular Stress Responses, Lysosomal Damage and Non-Canonical Autophagy
edited by and Alf Håkon Lystad
submission deadline 1 Mar 2027 | Viewed by 205 | Submission Open
Keywords: lysosomal damage; cellular stress responses; non-canonical autophagy; lysosomal homeostasis
(This special issue belongs to the Section Autophagy)
How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies submission deadline 10 Mar 2027 | 6 articles | Viewed by 19699 | Submission Open
Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention
(This special issue belongs to the Section Cell Microenvironment)
Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes submission deadline 15 Mar 2027 | 1 articles | Viewed by 3035 | Submission Open
Keywords: membrane receptors; molecular complex; membrane microdomains
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